Ginecología y Obstetricia de México

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>Journals >Ginecología y Obstetricia de México >Year 2010, Issue 07

Hernández-Valencia M, Zárate A
Genetic and hormonal effects on sexual differentiation. Paradoxically women requires androgens and man estrogens
Ginecol Obstet Mex 2010; 78 (07)

Language: Español
References: 22
Page: 365-370
PDF: 263.03 Kb.

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It had been established that the sexual structure of a person was determined by the type of hormonal production, what gave biological specificity of the estrogens to women and androgens to men, but recently this functional specificity has lost base due to the biological activity described in different tissues of men and women, today known as endocrine paradox. There are hormonal events that show the need of estrogens to correct development in men and androgens to women. In men the absence of effect of the estrogens produces deficient ossification of skeleton, persistence of the growth cartilage and osteoporosis in adult men. In women the production of androgens by suprarenal glandules is required to obtain the complete feminization. In women with chirurgic-induced menopause, the relation between androgens and the stimulation of sexual response has been established.
It has been described a hormone called kisspeptin, that it is attributed the potential to initiate the puberty because stimulates the hypothalamus; in absence of this hormone the women do not present their secondary sex characters, remaining immature sexually. The understanding of individuals needs of androgens and estrogens contribute to improve the control and care of the patient with hormonal deficiencies in any phase of the life.

Key words: endocrine paradox, androgens, estrogens, kisspeptin.


  1. Orentreich N, Brind JL, Pizer RI, Vogelman JH. Age changes and sex differences in serum dehidroepiandrosterone sulfate concentrations throughout adulthood. J Clin Endocrinol Metab 1984;59:551-556.

  2. Zárate A, Basurto L, Saucedo R. Paradoja endocrinológica, los hombres necesitan estrógenos y las mujeres andrógenos. Ciencia 2000;51:5-11.

  3. Jost A. Recherches sur la differentiation sexualle de l’embryon de lapin. III Rôle des gonadas faetales dans la différenciation sexualle somatique. Arch Anat Morphol Exp 1947;36;271-315.

  4. Shen WH, Moore CC, Iked Y, Parker KL, Ingraham HA. Nuclear receptor steroidogenic factor 1 regulates the Müllerian inhibiting substance gene: a link to the sex determination cascade. Cell 1994;77:651-661.

  5. Saitou M, Barton SC, Surani MA. A molecular programme for the specification of germ cell fate in mice. Nature 2002;418:293-300.

  6. Matova N, Cooley L. Comparative aspects of animal oogenesis. Dev Biol 2001;231:291-320.

  7. McLaren A, Buehr M. Development of mouse germ cells in cultures o fetal gonads. Cell Differ Dev 1990;31:185-195.

  8. Skaletsky H, Kuroda-Kawaguchi T, Minx PJ. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 2003;423:825-837.

  9. Mehlmann LM, Jones TL, Jaffe LA. Meiotic arrest in the mousefollicle maintained by a Gs protein in the oocyte. Science 2002;297:1343-1345.

  10. Matzuk MM, Burns KH, Viveiros MM, Eppig JJ. Intercellular communication in the mammalian ovary: oocytes carry the conversation. Science 2002;296:2178-2180.

  11. Prasad SV, Skinner SM, Carino C, Wang N, et al. Structure and function of the proteins of the mammalian Zona pellucida. Cells Tissues Organs 2000;166:148-164.

  12. Hernández-Valencia M, Zárate A. Amenorrea y trastornos de la menstruación. Acta Med 2006;4:197-201.

  13. Wataanabe K, Clarke TR, Lane AH, Wang X, Donahoe PK. Endogenous expression of Müllerian inhibiting substance in early postnatal rat Sertoli cells requires multiple steroidogenic factor-1 and GATA-4-binding sites. Proc Natl Acad Sci USA 2000;97:1624-1629.

  14. Parker KL, Schimmer BP. Transcriptional regulation of the genes encoding the cytochrome P-450 steroid hydroxylases. Vitam Horm 1995;51:339-370.

  15. Messager S, Chatzidaki EE, Ma D, Hendrick AG, et al. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Physiol 2005;102:1761-1766.

  16. Dhillo WS, Chaudhri OB, Patterson M, Thompson EL, et al. Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males. J Clin Endocrinol Metab 2005;90:6609-6615.

  17. Smith EP, Boyd J, Frank GR, Takahashi H, et al. Estrogen resistance caused by a mutation in the estrogen-receptor gene in man. N Engl J Med 1994;331:1056-1061.

  18. Zárate A, Hernández-Valencia M, Morán C, Ángeles L. El enfoque moderno de la osteoporosis. Rev Fac Med UNAM 2003;46:49-51.

  19. McLaren A. Mammalian germ cells: birth, sex, and immortality. Cell Struct Funct 2001;26:119-122.

  20. Hernández-Valencia M, Masón M, Fonseca ME, Mendoza C y col. Cambios de las glicoformas de FSH y LH en mujeres con falla ovárica tratadas con estrógenos. Rev Med IMSS 1998;36:435-439.

  21. Zárate A, Hernández-Valencia M, Ochoa R, Santos A. Experiencia clínica con tibolona en la terapia de reemplazo hormonal en la posmenopausia. Ginecol Obstet Mex 1996;64:47-50.

  22. Hernández-Valencia M, Ángeles L, Saucedo R, Basurto L, Zárate A. El tratamiento con dehidroepiandrosterona mejora los síntomas en las mujeres perimenopáusicas. Ginecol Obstet Mex 2005;73:245-249.

>Journals >Ginecología y Obstetricia de México >Year 2010, Issue 07

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