>Ginecología y Obstetricia de México
>Year 2015, Issue 06
López-Alarcón M, Vital-Reyes VS, Montalvo-Velarde I, Hinojosa-Cruz JC, PuelloTE
Interactions between markers of endothelial damage (homocysteine and asymmetric dimethylarginine) and antioxidants and B-vitamins in preeclamptic women
Ginecol Obstet Mex 2015; 83 (06)
PDF: 425.44 Kb.
Background: Preeclampsia is a pregnancy-related pathological condition
triggered by an abnormal placentation which produces endothelial dysfunction
(ED). ED, in turn, is associated with an increase in homocysteine
(hcy) and asymmetric dimethylarginine (ADMA); these molecules are
also increased when some of the B-vitamins are deficient. It is unclear
whether increases in hcy and ADMA during preeclampsia are the result
of ED, or the consequence of a B-vitamin deficiency.
Objective: To evaluate hcy, ADMA, folic acid (FA), vitamin B6 and B12
concentrations in patients with preeclampsia.
Methods: In a cross-sectional design 19 patients with severe preeclampsia
(preeclampsia) and 57 with normal pregnancy (no-preeclampsia),
paired by gestational age and body mass index, were studied. Plasma
hcy, ADMA, FA and vitamins B6 and B12 were determined. Non-parametric
statistics was used for between-groups comparisons and regression
analyses to evaluate interactions among molecules.
Results: 72% of women were vitamin B6 deficient, 40% were deficient
of B12 and 4% of FA. Preeclamptic patients presented hcy and ADMA
concentrations higher than no-preeclamptic ones. Inferential analyses
demonstrated that: hcy and ADMA are increased during preeclampsia
independently from vitamins blood concentration; that the risk for preeclampsia
is associated with high hcy but not with vitamins deficiency;
and that the ratio L-arginine:ADMA decreases the preeclampsia risk.
Conclusion: In patients with preeclampsia, increases of hcy and ADMA
are associated with ED, but not with deficiency of the vitamins involved
in their metabolism.
||homocysteine, ADMA, preeclampsia, B-vitamins.
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>Ginecología y Obstetricia de México
>Year 2015, Issue 06