2017, Number 05
Incidence and parental origin of aneuploidies in blastocysts: comparison between two centers of assisted reproduction in Mexico
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ABSTRACTObjetive: To determine the incidence and origin of aneuploidies in blastocysts of two assisted reproduction centers in México.
Material and Methods: Retrospective cohort study. In the period from january 2014 to December 2015, we incluided blastocysts on day 5 and day 6 of developmet, analyzed with preimplantation genetic screening; in two assisted reproduction centers. Blastocysts biopsied on day 7 and embryos that did not perform genetic diagnosis made, were excluded. The comparison of continuous variables: “T of student”, categorical: χ2.
Results: Were analized 450 blastocysts obtained from 80 patients. In center A, 132 blastocysts were on day five and 108 on day six; In the center B; 94 blastocysts were on day five and 116 on day six. Maternal age was higher in center A (37.3 ± 3.8 vs 32.4 ± 5.6 years, p ‹0.05). The total incidence of aneuploid blastocysts was similar in both centers; By differentiating between embryos from day five and day six if there was difference. The center A presented aneuploid blastocysts increase of day 6 compared with blastocysts of day 5 (61.1 vs 36.3%, p ‹0.05). In Center B the incidence of aneuploid embryos was similar between blastocysts from day 5 and 6 (48.9 vs 43.1; p › 0.05). In both centers, the main origin of aneuploidies was the maternal cause (center A, 68.7%, center B, 60.75%), followed by mixed origin (center A, 19.65%, center B, 28.1%) and finally of paternal cause (center A, 11.6%, center B, 11.1%).
Conclusions: The incidence of embryonic aneuploidies between embryos from day 5 and day 6 was different between centers. The origin was mainly maternal, followed by mixed and paternal.
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