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>Journals >Ginecología y Obstetricia de México >Year 2017, Issue 05


Reyes-Muñoz E, Martínez-Herrera EM, Ortega-González C, Arce-Sánchez L, Ávila-Carrasco A, Zamora-Escudero R
HOMA-IR and QUICKI reference values during pregnancy in Mexican women
Ginecol Obstet Mex 2017; 85 (05)

Language: Español
References: 27
Page: 306-313
PDF: 294.15 Kb.


Full text




ABSTRACT

Objetive: To determine the reference values of Homeostasis Model Assessment Insulin Resistance, (HOMA-IR) and Quantitative Insulin Sensitivity Check Index (QUICKI) to define insulin resistance (IR) in women without pregnancy (WP) and each trimester of pregnancy among Mexican women.
Methods: Cross-sectional study, women without pregnancy and pregnant women age ›18 years, without pathologies, pre-pregnancy body mass index (BMI) between 18.5-24.9 kg/m2 were included. All participants underwent CTOG 75gr-2h to rule out diabetes. We excluded women with gestational diabetes or any pre-pregnancy pathology, pre-pregnancy BMI ‹18.5 or ≥25 kg/m2 and multiple pregnancy. Percentiles 5 and 95 were calculated as reference values to define RI by HOMA-IR and QUICKI in women without pregnancy and each trimester of pregnancy.
Results: A total of 400 women were included, which were grouped as follows: Group of women without pregnancy (SE): n = 42, quarter Group (T) 1: n = 82, T2 Group: n = 159 and T3 group: n = 117. The reference values of HOMA-IR for the 5th and 95th percentile were: 0.33-2.6, 0.35-1.6, 0.40-2.9 and 0.38-2.6 and QUICKI: (0.33 to 0.46, 0.35 to 0.46, 0.32 to 0.45 and 0.33- 0.45, for groups SE, T1, T2 and T3, respectively.
Conclusion: The reference value of HOMA-IR to define RI in Mexican women should be ≥2.6 and the T1 ≥1.6, T2 pregnancy: ≥2.9 and T3 ≥2.6 and QUICKI in women ‹0.33, T1 ‹0.35, T2 ‹0.32 and T3 ‹0.33.


Key words: Insulin resistance, HOMA-IR, QUICKI, Pregnancy.


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>Journals >Ginecología y Obstetricia de México >Year 2017, Issue 05
 

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