>Year 2002, Issue 3
Martínez DC, Hurtado LLM, Martínez DI, Arellano MS, Torres AEM, Zaldívar RFR, Guerrero AA, Duarte TR, Camarillo BC, León GS
Absence of Tc-99m-MIBI uptake discards the presence of neoplastic tissue in patients with single, non-functional thyroid nodule
Cir Gen 2002; 24 (3)
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Objective: To study the capacity of thyroid gammagraphy with Tc-99m-MIBI (MIBI) for the differential diagnosis of benign lesions from those malignant in patients with palpable thyroid nodules resected surgically.
Material and methods: Between January 2000 and April 2001 thyroid gammagraphy with MIBI was performed in consecutive patients with palpable thyroid nodule who were afterwards subjected to thyroidectomy. Patients were divided in two groups, depending on whether the thyroid nodule revealed MIBI (positive MIBI) uptake or not (negative MIBI). Gammagraphic findings were compared with the definitive histopathologic result (DHPR).
Results: This analysis covers the findings from 64 consecutive patients. DHPR revealed that 47/64 had benign lesions and 17 had malignant lesions. From the 47 patients with benign DHPR diagnosis, 18 were classified as positive MIBI and 29 as negative MIBI, All 17 patients (100%) with malignant DHPR diagnosis were classified as positive MIBI. Sensitivity and predictive value of a negative MIBI was of 100%.
Conclusion: Our results agree with the findings already reported in the literature, MIBI uptake in the thyroid nodule is unable to differentiate between benign and malignant tissue. However, ´no patient with neoplastic thyroid lesion yielded a negative MIBI, therefore, in patients with non-functional thyroid nodule and negative MIBI conservative clinical follow-up is justified.
||Thyroid nodule, MIBI, gammagraphy, thyroid, cancer.
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>Year 2002, Issue 3