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>Journals >Cirujano General >Year 2002, Issue 3


Martínez DC, Hurtado LLM, Martínez DI, Arellano MS, Torres AEM, Zaldívar RFR, Guerrero AA, Duarte TR, Camarillo BC, León GS
Absence of Tc-99m-MIBI uptake discards the presence of neoplastic tissue in patients with single, non-functional thyroid nodule
Cir Gen 2002; 24 (3)

Language: Español
References: 32
Page: 179-183
PDF: 4. Kb.


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ABSTRACT

Objective: To study the capacity of thyroid gammagraphy with Tc-99m-MIBI (MIBI) for the differential diagnosis of benign lesions from those malignant in patients with palpable thyroid nodules resected surgically.
Material and methods: Between January 2000 and April 2001 thyroid gammagraphy with MIBI was performed in consecutive patients with palpable thyroid nodule who were afterwards subjected to thyroidectomy. Patients were divided in two groups, depending on whether the thyroid nodule revealed MIBI (positive MIBI) uptake or not (negative MIBI). Gammagraphic findings were compared with the definitive histopathologic result (DHPR).
Results: This analysis covers the findings from 64 consecutive patients. DHPR revealed that 47/64 had benign lesions and 17 had malignant lesions. From the 47 patients with benign DHPR diagnosis, 18 were classified as positive MIBI and 29 as negative MIBI, All 17 patients (100%) with malignant DHPR diagnosis were classified as positive MIBI. Sensitivity and predictive value of a negative MIBI was of 100%.
Conclusion: Our results agree with the findings already reported in the literature, MIBI uptake in the thyroid nodule is unable to differentiate between benign and malignant tissue. However, ´no patient with neoplastic thyroid lesion yielded a negative MIBI, therefore, in patients with non-functional thyroid nodule and negative MIBI conservative clinical follow-up is justified.


Key words: Thyroid nodule, MIBI, gammagraphy, thyroid, cancer.


REFERENCIAS

  1. Atkins LH. The thyroid. In: Freeman LM, editor. Freeman and Johnson’s clinical radionuclide imaging, 3rd Ed. Orlando, FL: CRC Press; 1984: 1275-317.

  2. Molitch ME, Beck JR, Dreisman M, Gottlieb JE, Pauker SG. The cold thyroid nodule: an analysis of diagnostic and therapeutic options. Endocr Rev 1984; 5: 185-99.

  3. Mazzaferri EL. Management of a solitary thyroid nodule. N Engl J Med 1993; 328: 553-9.

  4. Gharib H. Fine-needle aspiration biopsy of thyroid nodules: advantages, limitations and effect. Mayo Clin Proc 1994; 69: 44-9.

  5. Corena-Reyes E, Hurtado-López LM, Zaldivar-Ramírez FR, Duarte-Torres R, Basurto-Kuba E, Vázquez-Ortega R. Biopsia por aspiración con aguja fina en el nódulo tiroideo: apoyo del citopatólogo en la obtención de la muestra. Rev Med Hosp Gen Mex 2001; 64: 73-7.

  6. Mandell DL, Genden EM, Menchanick JI, Bergman DA, Biller HF, Urken ML. Diagnostic accuracy of fine-needle aspiration and frozen section in nodular thyroid disease. Otolaryngol Head Neck Surg 2001; 124: 531-6.

  7. Cochand-Priollet B, Guillausseau PJ, Chagnon S, Hoang C, Guillausseau-Scholer C, Chanson P et al. The diagnostic value of fine-needle aspiration biopsy under ultrasonography in nonfunctional thyroid nodules: a prospective study comparing cytologic and histologic findings. Am J Med 1994; 97: 152-7.

  8. Löwhagen T, Sprenger E. Cytologic presentation of thyroid tumors in aspiration biopsy smear. A review of 60 cases. Acta Cytol 1974; 18: 192-7.

  9. Hurtado-López LM, Zaldivar-Ramírez FR, Basurto-Kuba E. Decisión terapéutica ante un tumor folicular. Cir Gen 2001; 23: 145-7.

  10. Raber W, Kaserer K, Niederle B, Vierhapper H. Risk factors for malignancy of thyroid nodules initially identified as follicular neoplasia by fine-needle aspiration: results of a prospective study of one hundred twenty patients. Thyroid 2000; 10: 709-12.

  11. Tan GH, Gharib H, Reading CC. Solitary thyroid nodule: Comparison between palpation and ultrasonography. Arch Intern Med 1995; 155: 2418-23.

  12. Hisada K, Tonami N, Miyamae T, Hiraki Y, Yamazaki T, Maed T et al. Clinical evaluation of tumor imaging with 201Tl chloride. Radiology 1978; 129: 497-500.

  13. Harada T, Ito Y, Shimaoka K, Tanijuchi T, Matsudo. A, Sendo T. Clinical evaluation of 201thallium chloride scan for thyroid nodule. Eur J Nucl Med 1980; 5: 125-30.

  14. Hoschl R, Murray IP, McLean RG, Choy D, Indyk JS. Radiothallium scintigraphy in solitary nonfunctioning thyroid nodules. World J Surg 1984; 8: 956-62.

  15. Henze E, Roth J, Boerer H, Adam WE. Diagnostic value of early and delayed 201TI thyroid scintigraphy in the evaluation of cold nodules for malignancy. Eur J Nucl Med 1986; 11: 413-6.

  16. Bleichrodt RP, Vermey A, Piers DA, de Langen ZS. Early and delayed thallium 201 imaging. Diagnosis of patients with cold thyroid nodules. Cancer 1987; 60: 2621-3.

  17. el-Desouki M. TI-201 thyroid imaging in differentiating benign from malignant thyroid nodules. Clin Nucl Med 1991; 16: 425-30.

  18. Waxman AD. Thallium-201 in nuclear oncology. In: Freeman LM, editor. Nuclear medicine annual. New York, NY: Raven; 1991: 193-209.

  19. Wackers FJ, Berman DS, Maddahi J, Watson DD, Beller GA, Strauss HW et al. Technetium-99mhexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989; 62: 301-11.

  20. Aktolum C, Bayhan H, Kir M. Clinical experience with Tc-99m MIBI imaging in patients with malignant tumors. Preliminary results and comparison with Tl-201. Clin Nucl Med 1992; 17: 171-6.

  21. O’Tuama LA, Treves ST, Larar JN, Packard AB, Kwan AJ, Barnes PD et al. Thallium-201 versus technetium-99m-MIBI SPECT in evaluation of childhood brain tumors: a within-subject comparison. J Nucl Med 1993; 34: 1045-51.

  22. Caner B, Kitapcl M, Unlü M, Erbensi G, Calikoslu T, Gosus T et al. Technetium-99m-MIBI uptake in benign and malignant bone lesions: a comparative study with technetium-99m-MDP. J Nucl Med 1992; 33: 319-24.

  23. Nakahara H, Noguchi S, Murakami N, Hoshi H, Jinnouchi S, Najamuchi S et al. Technetium-99m-sestamibi scintigraphy compared with thallium-201 in evaluation of thyroid tumors. J Nucl Med 1996; 37: 901-4.

  24. Chiu ML, Kronauge JF, Piwnica-Worms D. Effect of mitochondrial and plasma membrane potentials on accumulation of hexakis (2-methoxy-isobutylisonitrile) Technetium (I) in cultured mouse fibroblasts. J Nucl Med 1990; 31: 1646-53.

  25. Delmon-Moingeon LI, Piwnica-Worms D, Van den Abbeele AD, Holman Bl, Davison A, Jones AG. Uptake of the cation hexakis (2-methoxyisobutylisonitrile)-technetium-99m by human carcinoma cell lines in vitro. Cancer Res 1990; 50: 219B-202.

  26. Piwnica-Worms D, Holman BL. Noncardiac applications of hexakis (alkyl isonitrile) technetium 99m complexes. J Nucl Med 1990; 31: 1166-7.

  27. Beller GA, Watson DD. Physiological basis of myocardial perfusion imaging with the technetium 99m agents. Semin Nucl Med 1991; 21: 173-81.

  28. Alonso O, Mut F, Lago G, Aznarez A, Nuñez M, Canepa J et al. 99 Tc(m)-MIBI scanning of the thyroid gland in patients with markedly decreased pertechnetate uptake. Nucl Med Commun 1998; 19: 257-61.

  29. Osmanagaoglu K, Schelstraete K, Lippens M, Obrie E, De Feyter I. Visualization of a parathyroid adenoma with Tc-99m MIBI in a case with iodine saturation and impaired thallium uptake. Clin Nucl Med 1993; 18: 214-6.

  30. Muller SP, Piotrowsky B, Guth-Tougelides B, Reiners C. Tc-99m MIBI and Tl-201 uptake in thyroid carcinoma [Abstract]. J Nucl Med 1988; 29: 854.

  31. Földes I, Levay A, Stotz G. Comparative scanning of thyroid nodules with technetium-99m pertechnetate and technetium-99m methoxyisobutylisonitrile. Eur J Nucl Med 1993; 20: 330-3.

  32. Kresnik E, Gallowitsch HJ, Mikosch P, Gomez I, Lind P. Technetium-99m-MIBI scintigraphy of thyroid nodules in an endemic goiter area. J Nucl Med 1997; 38: 62-5.






>Journals >Cirujano General >Year 2002, Issue 3
 

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