Acta Ortopédica Mexicana

Ruíz-Mejía O, Oribio-Gallegos JA, Pimentel-Rangel J, Valle-De Lascurain G
Congenital Analgesia: report of 2 cases
Acta Ortop Mex 2018; 32 (2)

Language: Español
References: 15
Page: 102-107
PDF: 278.61 Kb.

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ABSTRACT

Congenital analgesia is a rare condition, reporting in the international literature in rare cases since 1932, when it was first described. Its cause has been the subject of development of multiple theories and studies through the years. Currently various studies and experiments as its origin point mutation in the gene encoding SC9NA sodium channels, which have an important role in nociceptive transmission signals in the human body. The purpose of this study is to present two cases that were valued in the department of pediatric orthopedics at UMAE HTYOLV, patients whose insensitivity to pain has produced significant injuries that were once cause for valuation of the hospital.


Key words: Analgesia congenital, absence of pain, orthopedic sequels, analgia.


REFERENCES

  1. Dearborn GV. A case of congenital general pure analgesia. Journal of Nervous and Mental Disease. 1932; 75: 612-5.

  2. García RM, Castillo MO, Camargo MJ, López-Portilla MT. Síndrome de indiferencia congénita al dolor: una enfermedad genética rara. Boletín MGI. 2005; 9(1):

  3. Nagasako EM, Oaklander AL, Dworkin RH. Congenital insensitivity to pain: an update. Pain. 2003; 101(3): 213-9.

  4. Bolgul BS, Hamamci N, Agackiran E, Celenk S, Ayna B. Congenital insensitivity to pain: a case report with dental implications. HK J Paediatrics. 2010; 15(3): 234-7.

  5. Jaffe HL. Enfermedades metabólicas, degenerativas e inflamatorias de huesos y articulaciones. La Prensa Médica; 1978.

  6. Karmani S, Shedden R, De Sousa C. Orthopaedic manifestations of congenital insensitivity to pain. J R Soc Med. 2001; 94(3): 139-40.

  7. Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, et al. An SCN9A channelopathy causes congenital inability to experience pain. Nature. 2006; 444(7121): 894-8.

  8. Kotsias BA. Enfermedades de los canales iónicos. Medicina (B Aires). 1997; 57(5): 617-28.

  9. Landrieu P, Said G, Allaire C. Dominantly transmitted congenital indifference to pain. Annals of Neurology. 1990; 27(5): 574-8.

  10. Núñez R. Analgesia congénita universal. Rev Med Hosp Nal Niños Dr. Carlos Sáez Herrera. 1972; 7(1): 43-50.

  11. Ogden TE, Robert F, Carmichael EA. Some sensory syndromes in children: indifference to pain and sensory neuropathy. J Neurol Neurosurg Psychiat. 1959; 22(4): 267-76.

  12. Ogryzlo MA. A familial peripheral neuropathy of unknown etiology resembling Morvan’s disease. Can Med Assoc J. 1946; 54: 547-53.

  13. Rodríguez PM, Fernández DP, Cruz VJ, Cendón OM, Anaya PL, Sánchez MM. Anestesia epidural a un niño con fractura de fémur e insensibilidad congénita al dolor. Rev Esp Anestesiol Reanum. 2002; 49: 555-57.

  14. Cummins TR, Sheets PL, Waxman SG. The roles of sodium channels in nociception: implications for mechanisms of pain. Pain. 2007; 131(3): 243-57.

  15. Drenth JP, Waxman SG. Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders. J Clin Inv. 2007; 117(12): 3603-9.