Acta Ortopédica Mexicana

Álvarez‑Narváez AR, Elizalde‑Martínez E, Moheno‑Gallardo AJ, Lares‑Cárdenas LA, López‑Valencia J, Torres‑González R, Morales‑de los Santos R
Bacteriological-clinical association and characterization in Pyogenic Spondylodiscitis
Acta Ortop Mex 2019; 33 (3)

Language: Español
References: 12
Page: 141-145
PDF: 122.64 Kb.

[Fulltext - PDF]


Objective: Determine the association between clinical characteristics and laboratory studies with the type of isolated microorganism in blood cultures of patients with Pyogenic Spondylodiscitis. Material and methods: It is a cross-analytical study, clinical records of patients with Pyogenic Spondylodiscitis were reviewed from January 2013 to January 2017. Univariate descriptive analysis was performed using frequencies and percentages for qualitative variables, central trend measures and dispersion for quantitative ones. Bivariate analysis by testing of χ2 or Fisher’s exact test. Analysis of quantitative variables using T Student or Mann-Whitney U. Spearman’s correlation coefficient was used. Considering statistical significance p ‹ 0.05. Results: A sample of 34 patients was obtained, 20 (58%) were women, median (Me) of age 60 years (52-66). Was isolated into blood cultures, Gram-positive bacteria 11 (32.4%) gram negatives 23 (67.6%). The microorganism most common isolate was Escherichia coli 12 (35.3%). Patients with Gram-negative spondylodiscitis had mild pain and globular sedimentation rate (VSG) Me 26 mm/hra P (18-36), patients with Gram-positive spondylodyscitis had severe pain and VSG Me 38 mm/h P (34-40) (p= 0.000 and 0.028, respectively). VSG and pain in the group of patients with gram-negative bacteria spondylodiscitis had a moderate Spearman correlation coefficient of 0.418, (p = 0.047); in the Gram positives group, a low correlation coefficient of Spearman 0.228, (p = 0.507). Conclusion: There is a clinical and statistical association significant between types of isolated microorganism in blood culture, pain intensity valued on analog visual scale (EVA) and VSG levels.

Key words: Pyogenic Spondylodiscitis, bacteria Gram negatives, Gram-positive bacteria, sedimentation rate, analogue visual scale, clinical association bacteriological.


  1. Nickerson EK, Sinha R. Vertebral osteomyelitis in adults: an update. Br Med Bull. 2016; 117(1): 121-38.

  2. Márquez SP. Espondilodiscitis. Radiologia. 2016; 58: 50-9.

  3. Menon KV, Sorour TM. Epidemiologic and demographic attributes of primary spondylodiscitis in a middle eastern population sample. World Neurosurg. 2016; 95(1): 31-9.

  4. Kang SJ, Jang HC, Jung SI, Choe PG, Park WB, Kim C-J, et al. Clinical characteristics and risk factors of pyogenic spondylitis caused by gram-negative bacteria. PLoS One. 2015; 10(5): e0127126.

  5. Lee CY, Wu MH, Cheng CC, Huang TJ, Huang TY, Lee CY, et al. Comparison of gram-negative and gram-positive hematogenous pyogenic spondylodiscitis: clinical characteristics and outcomes of treatment. BMC Infect Dis. 2016; 16(1): 735.

  6. Skaf GS, Domloj NT, Fehlings MG, Bouclaous CH, Sabbagh AS, Kanafani ZA, et al. Pyogenic spondylodiscitis: an overview. J Infect Public Health. 2010; 3(1): 5-16.

  7. Gouliouris T, Aliyu SH, Brown NM. Spondylodiscitis: update on diagnosis and management. J Antimicrob Chemother. 2010; 65(Suppl. 3): 11-24.

  8. Cheung WY, Luk KDK. Pyogenic spondylitis. Int Orthop. 2012; 36(2): 397-404.

  9. Park KH, Cho OH, Jung M, Suk KS, Lee JH, Park JS, et al. Clinical characteristics and outcomes of hematogenous vertebral osteomyelitis caused by gram-negative bacteria. J Infect. 2014; 69(1): 42-50.

  10. Graham SM, Fishlock A, Millner P, Sandoe J. The management gram-negative bacterial haematogenous vertebral osteomyelitis: a case series of diagnosis, treatment and therapeutic outcomes. Eur Spine J. 2013; 22(8): 1845-53.

  11. Berbari EF, Kanj SS, Kowalski TJ, Darouiche RO, Widmer AF, Schmitt SK, et al. 2015 Infectious Diseases Society of America (IDSA) clinical practice guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults a. 2015; 6186): e26-46.

  12. Park KH, Chong YP, Kim SH, Lee SO, Choi SH, Lee MS, et al. Clinical characteristics and therapeutic outcomes of hematogenous vertebral osteomyelitis caused by methicillin-resistant Staphylococcus aureus. J Infect. 2013; 67(6): 556-64.