Acta Ortopédica Mexicana

Hernández‑Téllez IE, Godínez‑Victoria MC, Floriano‑Sánchez E, Sáenz‑Guerra J
IGF-1 levels in anterior cruciate ligament reconstruction using allograft vs autograft in patients at Central Military Hospital
Acta Ortop Mex 2019; 33 (4)

Language: Español
References: 25
Page: 225-231
PDF: 141.89 Kb.

[Fulltext - PDF]

ABSTRACT

Background: Treatment of ACL injury is surgical reconstruction. It is not known whether the result is better depending on the type of graft used. Insulin-like growth factor type 1(IGF-1) is a powerful stimulant of extracellular matrix and chondrocyte growth. Material and methods: Experimental, analytical, prospective, longitudinal study in patients with ACL reconstruction in a period from 2016 to 2017. The concentration of IGF-1 in synovial fluid of these patients operated with allograft and autograft was determined, its association with postoperative evolution was determined. For statistical analysis, two-way ANOVA with Mann-Whitney post-hoc U was used. Results: A significant increase in IGF-1 was identified in the allograft group at 90 days of postopertory. In the autograft group, a significant increase in IGF-1 was observed from 30 days of postoperative. The autograft group was found to have significantly higher levels of IGF-1 (3.27 ± 0.09 ng/ml) compared to the allograft group (2.80 ± 0.11 ng/ml; p ‹ 0.001) at 90 days after graft placement. Discussion: IGF-1 levels were higher in patients with autologous graft, knee functionality was clinically similar in both groups at 30 and 90 days.


Key words: Reconstruction, anterior cruciate ligament, autograft, allograft, results.


REFERENCES

  1. Spindler K, Wright R. Clinical practice. Anterior cruciate ligament tear. N Engl J Med. 2008; 359(20): 2135-42.

  2. Orlando Júnior N, de Souza Leão MG, de Oliveira NH. Diagnosis of the knee injuries: comparison of the physical examination and magnetic resonance imaging with the findings from arthroscopy. Rev Bras Ortop. 2015; 50(6): 712-9.

  3. Berumen NE, Paz GM. Lesiones multiligamentarias de rodilla. Ortho-tips. 2009; 5 (1): 49-58.

  4. Nuelle CW, Cook JL, Gallizzi MA, Smith PA. Posterior single incision semitendinosus harvest for a quadrupled anterior cruciate ligament graft construct: determination of graft length and diameter based on patient sex, height, weight and body mass index. Arthroscopy. 2015; 31(4): 684-90.

  5. Colombet P, Dejour D, Panisset JC, Siebold R, French Arthroscopy Society. Current concept of partial anterior cruciate ligament ruptures. Orthop Traumatol Surg Res. 2010; 96(8 Suppl): S109-18.

  6. Carey JL, Dunn WR, Dahm DL, Zeger SL, Spindler KP. A systematic review of anterior cruciate ligament reconstruction with autograft compared with allograft. J Bone Joint Surg Am. 2009; 91(9): 2242-50.

  7. Arcurui F, Abalo E, Barclay F. Uso de escores para evaluación de resultados en cirugía de ligamento cruzado anterior. Artroscopia. 2010; 17(3): 241-7.

  8. Zeng C, Gao SG, Li H, Yang T, Luo W, Li YS, et al. Autograft vs allograft in anterior cruciate ligament reconstruction: a meta-analysis of randomized controlled trials and systematic review of overlapping systematic reviews. Arthroscopy. 2016; 32(1): 153-63.

  9. Nagda SH, Altobelli GG, Bowdry KA, Brewster CE, Lombardo SJ. Cost analysis of outpatient anterior cruciate ligament reconstruction. Clin Orthop Relat Res. 2010; 468(5): 1418-22.

  10. Balcells GA, Prieto VJ, Yuste AJ. La clínica y el laboratorio. Interpretación de análisis y pruebas funcionales, exploración de los síndromes y cuadro biológico de las enfermedades. 21 ed., Barcelona, Elsevier-Masson, 2010, pp. 110-132.

  11. Sasaki N, Farraro KF, Kim KE, Woo SL. Biomechanical evaluation of the quadriceps tendon autograft for anterior cruciate ligament reconstruction. Am J Sports Med. 2014; 42(3): 723-30.

  12. Walsh W. Gene therapy and ligament healing (Orthopedic Biology and Medicine). Humana Press Inc., 2006, pp. 297-315.

  13. Lyras DN, Kazakos K, Agrogiannis G, Verettas D, Kokka A, Kiziridis G, Chronopoulos E, et al. Experimental study of tendon healing early phase; is IGF-1 expression influenced by platelet rich plasma gel. Orthop Traumatol Surg Res. 2010; 96(4): 381-7.

  14. Kobayashi K, Yamazaki M, Honda T, Goto KI, Moriya H, Fujimura S. Effect of insulin-like growth factor 1 and basic fibroblast growth factor on DNA synthesis and collagen production in cultured anterior cruciate ligament cells. J Orthop Sci. 1997; 2(5): 349-56.

  15. Mobasheri A. Osteoarthritis year 2012 in review: biomarkers. Osteoarthritis Cartilage. 2012; 20(12): 1451-64.

  16. Elsaid KA, Machan JT, Waller K, Fleming BC, Jay GD. The impact of anterior cruciate ligament injury on lubricin metabolism and the effect of inhibiting TFN-alfa on chondroprotection in an animal model. Arthritis Rheum. 2009; 60(10): 2997-3006.

  17. Clemens D, Carter S, Innes J, Ollier W, Day J. Gene expression profiling of normal and ruptured canine anterior cruciate ligaments. Osteoarthritis Cartilage. 2008; 16(2): 195-203.

  18. Li Y, Wang Y, Chubinskaya S, Schoeberl B, Florine E, Kopesky P, et al. Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: relevance to post-traumatic osteoarthritis. Osteoarthritis Cartilage. 2015; 23(2): 266-74.

  19. Bigoni M, Turati M, Gandolla M, Sacerdote P, Piatti M, Castelnuovo A, et al. Effects of ACL reconstructive surgery on temporal variations of cytokine levels in synovial fluid. Mediators Inflamm. 2016; 2016: 8243601.

  20. Tibor LM, Long JL, Chilling PJ, Lily RJ, Carpenter JE, Miller BS. Clinical outcomes after anterior cruciate ligament reconstruction: a meta-analysis of autograft versus allograft tissue. Sports Health. 2010; 2(1): 56-72.

  21. Chen Ch, Lee Ch. Biological fixation in anterior cruciate ligament surgery. Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology. 2014; 1(2): 48-53.

  22. Widener DB, Wilson DJ, Galvin JW, Marchant BG, Arrington ED. The prevalence of meniscal tears in young athletes undergoing revision anterior cruciate ligament reconstruction. Arthroscopy. 2015; 31(4): 680-3.

  23. Zhang X, Ma Y, Fu X, Liu Q, Shao Z, Dai L, et al. Runx2 modified adipose-derived stem cells promote tendon graft integration anterior cruciate ligament reconstruction. Sci Rep. 2016; 6: 19073.

  24. Espregueira-Mendes J, Pereira H, Monteiro A, Oliveira JM, Reis RL, Ripóll PL, Thomas N. ALC two stage revision surgery: a practical guide. Springer, Berlin, Heildelberg, 2014.

  25. Forriol F, Ripoll PL. La reparación del ligamento cruzado anterior, solución de un problema histórico del siglo XX. Trauma Fund Mapfre. 2012; 1(23): 29-47.