Acta Ortopédica Mexicana

Hernández‑Téllez IE, Godínez‑Victoria MC, Floriano‑Sánchez E, Sáenz‑Guerra J
IGF-1 levels in anterior cruciate ligament reconstruction using allograft vs autograft in patients at Central Military Hospital
Acta Ortop Mex 2019; 33 (4)

Language: Español
References: 25
Page: 225-231
PDF: 141.89 Kb.

[Fulltext - PDF]


Background: Treatment of ACL injury is surgical reconstruction. It is not known whether the result is better depending on the type of graft used. Insulin-like growth factor type 1(IGF-1) is a powerful stimulant of extracellular matrix and chondrocyte growth. Material and methods: Experimental, analytical, prospective, longitudinal study in patients with ACL reconstruction in a period from 2016 to 2017. The concentration of IGF-1 in synovial fluid of these patients operated with allograft and autograft was determined, its association with postoperative evolution was determined. For statistical analysis, two-way ANOVA with Mann-Whitney post-hoc U was used. Results: A significant increase in IGF-1 was identified in the allograft group at 90 days of postopertory. In the autograft group, a significant increase in IGF-1 was observed from 30 days of postoperative. The autograft group was found to have significantly higher levels of IGF-1 (3.27 ± 0.09 ng/ml) compared to the allograft group (2.80 ± 0.11 ng/ml; p ‹ 0.001) at 90 days after graft placement. Discussion: IGF-1 levels were higher in patients with autologous graft, knee functionality was clinically similar in both groups at 30 and 90 days.

Key words: Reconstruction, anterior cruciate ligament, autograft, allograft, results.


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