Table 3: Cutoff points, sensibility, specificity, OR and 95%CI

in complicated acute appendicitis.

Study

Cutoff

value

Sens

(%)

Spec

(%)

OR

[95%CI]

p

Population

Leukocytes

HPC

10,195

77.60

46.6

2.63

[1.5-4.6]

0.001

C

Al-Gaithy,

(2012)21

11,100

76.62

72.41

NR

< 0.001

A

McGowan

et al. (2013)22

11,000

81.20

36.70

2.61

[1.7-4.01]

NR

A

Shimizu

et al. (2016)23

11,500

NR

NR

NR

< 0.001

A

Beecher

et al. (2016)24

12,250

70.03

68.13

NR

NR

A

Aydin

et al. (2016)25

13,800

53.30

67.00

3.10

[1.71-5.62]

< 0.001

A

Jung

et al. (2016)26

10,600

71.20

68.20

5.29

[2.27-12.37]

< 0.001

A

Shin

et al. (2018)27

10,750

81.80

75.00

4.39

[1.36-14.18]

< 0.001

A

Celik

et al. (2019)28

14,870

86.10

41.60

NR

0.001

C

Prasetya

et al. (2019)29

13,630

66.10

62.50

3.25

[1.53-6.90]

0.008

C

Vargas-Rodríguez

et al. (2022)30

11,000

78.22

22.46

1.04

[0.56-1.93]

NR

A

Patmano

et al. (2022)31

13,610

70.10

53.70

1.21

[1.08-1.36]

< 0.001

A

Mekrugsakit &

Tullavardhana,

(2023)32

15,150

62.00

50.00

NR

NR

A

Neutrophils

HPC

7,050

80.50

46.60

3.59

[2.02-6.39]

< 0.001

C

Al-Gaithy,

(2012)21

7,540

81.82

65.52

NR

< 0.001

A

McGowan

et al. (2013)22

7,000

88.30

29.60

1.98

[1.28-3.06]

NR

A

Beecher

et al. (2016)24

9,350

76.19

60.00

NR

NR

A

Jung

et al. (2016)26

8,100

71.20

65.90

4.77

[2.06-11.07]

< 0.001

A

Celik

et al. (2019)28

76.00*

97.20

32.20

NR

< 0.001

C

Prasetya

et al. (2019)29

80.05*

74.50

66.70

5.85

[2.62-13.05]

< 0.0001

C

Vargas-Rodríguez

et al. (2022)30

85.00*

54.46

65.94

2.17

[1.28-3.66]

NR

A

Mekrugsakit &

Tullavardhana,

(2023)32

80.00*

64.00

52.00

NR

NR

A

Eosinophils

HPC

55.00

67.80

53.40

2.41

[1.40-4.16]

0.001

C

NLR

HPC

3.18

88.80

37.00

6.64

[2.44-8.83]

< 0.001

C

Ishizuka

et al. (2012)33

8.00

73.00

39.00

3.02

[1.54-5.94]

0.001

C+A

Kahramanca

et al. (2014)34

5.74

70.80

48.50

NR

< 0.001

A

Kelly

et al. (2015)35

7.53

80.00

55.00

NR

< 0.001

C

Shimizu

et al. (2016)23

5.00

NR

NR

NR

< 0.001

A

Yardımci

et al. (2016)36

7.95

78.00

67.00

3.04

[2.46-5.22]

0.001

C+A

Beecher

et al. (2016)24

5.47

78.43

70.33

NR

NR

A

Aydin

et al. (2016)25

4.87

70.70

56.30

3.03

[1.66-5.49]

< 0.001

A

Sevinc

et al. (2016)37

4.80

78.40

41.70

2.60

[NR]

NR

C+A

Jung

et al. (2016)26

5.60

78.00

65.90

6.84

[2.85-16.43]

< 0.001

A

Khan

et al. (2018)38

6.36

84.00

48.00

NR

< 0.001

C+A

Shin

et al. (2018)27

6.90

61.80

75.00

5.65

[0.57-55.97]

0.139

A

Celik

et al. (2019)28

2.87

61.10

73.20

NR

< 0.001

C

Prasetya

et al. (2019)29

6.59

84.60

56.60

7.15

[2.28-22.40]

< 0.001

C

Hajibandeh

et al. (2020)39‡

8.80

76.90

100.00

43.33

[3.90-481.82]

< 0.001

C+A

Begic-Kapetanovic

et al. (2021)40

5.61

79.00

81.0

NR

< 0.001

C

Cruz-Vallejo

et al. (2021)41

10.40

77.78

67.14

2.53

[1.27-5.05]

< 0.001

C

Rajalingam

et al. (2022)42

6.96

26.50

91.60

3.95

[2.63-5.99]

< 0.001

A

Ayeni

et al. (2022)43

8.86

70.30

70.00

NR

< 0.001

C

Prasetya

et al. (2019)29

5.50

61.39

43.48

1.22

[0.82-1.52]

NR

A

Patmano

et al. (2022)31

6.69

77.00

76.30

NR

< 0.001

A

Mekrugsakit &

Tullavardhana,

(2023)32

7.40

62.00

58.00

NR

NR

A

Ortiz-Ley

et al. (2023)9

7.40

NR

NR

2.20

[0.63-7.66]

0.20

C§

12.43

NR

NR

1.82

[0.76-4.37]

0.17

C

16.80

NR

NR

2.26

[0.72-7.09]

0.15

C||

Moreno-Alfonso

et al. (2023)19

7.77

72.00

76.00

8.20

[4.00-16.40]

NR

C

PLR

HPC

187.40

57.10

60.30

2.01

[1.17-3.47]

0.011

C

Shin

et al. (2018)27

180.10

51.50

75.00

1.30

[0.29-5.79]

0.727

A

Celik

et al. (2019)28

284.00

42.00

86.00

NR

0.004

C

Cruz-Vallejo

et al. (2021)41

284.00

77.78

63.57

2.11

[1.09-4.08]

< 0.001

C

Rajalingam

et al. (2022)42

180.50

22.40

89.00

2.35

[1.59-3.47]

< 0.001

A

Ayeni

et al. (2022)43

193.67

64.00

61.00

NR

< 0.001

C

Mekrugsakit &

Tullavardhana,

(2023)32

144.40

55.00

44.00

NR

NR

A

Ortiz-Ley

et al. (2023)9

405.70

NR

NR

10.00

[1.10-90.59]

0.049

C§

687.80

NR

NR

4.75

[0.53-42.54]

0.270

C

504.70

NR

NR

2.78

[0.46-16.49]

0.460

C||

Yesilalioglu

et al. (2023)44

133.73

60.00

58.40

NR

0.032

A

Moreno-Alfonso

et al. (2023)19

213.32

60.00

85.00

8.52

[3.90-18.30]

NR

C

A = adults.

C = children.

CI = confidence interval.

HPC = Hospital Pediátrico Coyoacán.

NLR = neutrophil/lymphocyte ratio.

NR = not reported.

OR = odds ratio.

PLR = platelet/lymphocyte ratio.

Sens = sensitivity.

Spec = specificity.

* Data recorded in percentage.

‡ Systematic review and meta-analysis.

§ Preschoolers.

School-children.

|| Teenagers.