cms252b-T1

Table 1: Predictive algorithms to

specific features of MACARENHA.

Factor to

evaluate

Algorithm

Construct

variables

Description

Visceral

adiposity

and

incidence

of T2DM

METS-IR

Serum glucose,

HDL-c, BMI,

Triglycerides

Non-insulin-based fasting scale for assessing insulin sensitivity validated against the euglycemic-hyperinsulinemic clamp (EHC)

VAT

METS-VF

METS-IR,

gender, waist

circumference,

height, age

Scale in patients with Metabolic Syndrome predicting the incidence of T2DM and HBP, independently of BMI, in primary care

MASLD

FLI, MRE, or THE

GGT, BMI,

waist circumference,

and

triglycerides

Requires validation

Mood

Beck

Depression

Questionnaire

Symptoms

and signs of

depression

and anxiety

A simplified, self-applied, 21-item scale with four response options that considers the patient’s condition over the past two weeks

BMI = body mass index.

FLI = fatty liver index.

GGT = gamma-glutamyl transferase.

BP = high blood pressure.

HDL = high-density lipoprotein.

MASLD = metabolic dysfunction-associated steatotic liver disease.

METS-IR = metabolic score for insulin resistance.

METS-VF = metabolic score for visceral fat.

MRE = magnetic resonance elastography.

T2DM = type 2 diabetes mellitus.

THE = transient hepatic elastography.

VAT = visceral adipose tissue.

Table 1: Predictive algorithms to specific features of MACARENHA.
Factor to evaluate	Algorithm	Construct variables	Description
Visceral adiposity and incidence of T2DM	METS-IR	Serum glucose, HDL-c, BMI, Triglycerides	Non-insulin-based fasting scale for assessing insulin sensitivity validated against the euglycemic-hyperinsulinemic clamp (EHC)
VAT	METS-VF	METS-IR, gender, waist circumference, height, age	Scale in patients with Metabolic Syndrome predicting the incidence of T2DM and HBP, independently of BMI, in primary care
MASLD	FLI, MRE, or THE	GGT, BMI, waist circumference, and triglycerides	Requires validation
Mood	Beck Depression Questionnaire	Symptoms and signs of depression and anxiety	A simplified, self-applied, 21-item scale with four response options that considers the patient’s condition over the past two weeks
BMI = body mass index. FLI = fatty liver index. GGT = gamma-glutamyl transferase. BP = high blood pressure. HDL = high-density lipoprotein. MASLD = metabolic dysfunction-associated steatotic liver disease. METS-IR = metabolic score for insulin resistance. METS-VF = metabolic score for visceral fat. MRE = magnetic resonance elastography. T2DM = type 2 diabetes mellitus. THE = transient hepatic elastography. VAT = visceral adipose tissue.