|
Table 6: Empirical antimicrobial therapy for infective endocarditis (IE) without an identified pathogen. |
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|
Infection type |
First-line treatment |
Second-line treatment |
|
Native valve non-IV drug user |
Penicillin G 20 million IU IV daily or Ampicillin 12 g IV daily plus Dicloxacillin 2 g IV q6h Gentamicin 1 mg/kg IV or IM q8h |
Vancomycin 15 mg/kg q12h plus Gentamicin 1 mg/kg or IM q8h |
|
Native valve IV drug user |
Dicloxacillin 2 g IV q6h |
Vancomycin 15 mg/kg q12h plus Gentamicin 1 mg/kg or IM q8h |
|
Prosthetic valve early IE (< 2 months postoperative) |
Vancomycin 15 mg/kg q12h plus Gentamicin 1 mg/kg IV or IM q8h plus Rifampin 600 mg daily |
|
|
Prosthetic valve late IE (> 2 months postoperative) |
Ampicillin 12 g IV daily plus Dicloxacillin 1 g IV q6h Gentamicin 1 mg/kg q8h |
Vancomycin 15 mg/kg q12h plus Gentamicin 1 mg/kg or IM q8h |