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Table 1: Integrated framework combining polygenic risk score, coronary artery calcium, and lipoprotein(a) for cardiovascular risk stratification. |
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Tool |
What it captures |
Biological timing |
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PRS |
Genetic susceptibility |
Lifelong (from birth) |
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CAC |
Subclinical atherosclerosis |
Intermediate stage |
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Lp(a) |
Inherited thrombogenic risk |
Constant |
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CAC = Coronary Artery Calcium. Lp(a) = lipoprotein(a). PRS = Polygenic Risk Score. |
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