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Table 1: Classification of systemic lymphoma according to Ann Arbor. |
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Ann Arbor classification (modified by Musshoff) |
Treatment |
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I. Affects only the stomach, respecting the lymph nodes |
Erradicate H. Pylori |
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• I1 limited to mucosa and submucosa |
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• I2: Invades the deepest layers of the stomach (up to serosa) |
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II. Affects the lymph nodes on the same side of the diaphragm as the stomach |
Erradicate H. pylori |
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• II1: local, para-gastric or para-intestinal ganglia |
Radiotherapy or rituximab |
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• II2: distant nodes (mesenteric, para-aortic, para-cavity, pelvic or inguinal) |
Rituximab ± polychemotherapy |
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III. Affects the lymph nodes on both sides of the diaphragm |
Rituximab ± polychemotherapy |
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IV. Lymphoma is spread throughout the body |
Rituximab ± polychemotherapy |