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Table 4: REAL/WHO classification of lymphoproliferative neoplasms |
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B-cell neoplasms |
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I. B-cell precursor neoplasm |
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Leukemia/lymphoblastic lymphoma B precursor |
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II. Mature (peripheral) B-cell neoplasia |
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Chronic B-cell leukemia/small lymphocytic lymphoma |
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B-cell prolymphocytic leukemia |
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Lymphoplasmacytic Lymphoma |
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B-cell lymphoma of the splenic margin (± hairy lymphocytes) |
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Hairy Cell Leukemia |
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Plasma cell myeloma/plasmacytoma |
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B-cell lymphoma of the extranodal marginal area of mucosal-associated lymphoid tissue type |
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Nodal margin lymphoma (± B-cells monocytoids) |
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Follicular Center Lymphoma |
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Mantle cell lymphoma |
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Diffuse large B-cell lymphoma |
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Mediastinal large B-cell lymphoma |
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Primary effusion lymphoma |
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Burkitt’s Lymphoma/Burkitt’s Cell Leukemia |
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T-cell and NK cell neoplasms |
|
I. T-Cell Precursor Neoplasia |
|
Leukemia/precursor T-lymphoblastic lymphoma |
|
II. Mature (peripheral) T-cell neoplasia |
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T-cell prolymphocytic leukemia |
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T-cell lymphocytic-granular leukemia |
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Aggressive NK cell leukemia |
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Adult T-cell leukemia/lymphoma |
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Extranodal NK/T cell lymphoma, nasal type |
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Enteropathic T-cell lymphoma |
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Gamma/delta T-cell hepatosplenic lymphoma |
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Subcutaneous lymphoma similar to T-cell panniculitis |
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Sezary syndrome/mycosis fungoides |
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Anaplastic large cell lymphoma, primary skin type |
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Peripheral T-cell lymphoma, nonspecific |
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Angioimmunoblastic T-cell lymphoma |
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Anaplastic large cell lymphoma, primary systemic type |
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Hodgkin’s disease/lymphoma |
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I. Predominantly lymphocytic |
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II. Nodular Sclerosis |
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III. Mixed cells |
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IV. Lymphocytic depletion |
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V. Lymphocyte-rich classic |
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Modified from: Görgün AE, Borowitz MJ. A clinician’s guide to the updated REAL/WHO classification of non-Hodgkin’s lymphoma: part I (indolent lymphomas). Turkish Journal of Cancer. 2000; 30: 5-14. |