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Table 1: General information for BMP. |
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|
BMP type |
Classification |
Manufacturer |
Synthesis |
Usage vehicle |
Estimated price in Latin America (USD) |
Availability in Latin America |
|
rhBMP-2 (Infuse®) |
Human recombinant (CHO) |
Medtronic |
Produced in CHO cells (Chinese hamster ovary) |
Absorbable collagen matrix |
$4,500-7,000 per kit |
Available in some countries |
|
rhBMP-7 (OP-1 Putty) |
Human recombinant (CHO) |
Stryker |
Produced in CHO cells |
Collagen and carrier protein vehicle |
$3,500-5,500 per dose |
Limited availability |
|
BMP-2 in hydroxyapatite |
Human recombinant (CHO) |
Geistlich Pharma |
Recombinant production with synthetic hydroxyapatite |
Hydroxyapatite and collagen matrix |
$3,000-5,500 per kit |
Available in some countries |
|
e.rh-BMP2 (Cowell BMP) |
Human recombinant (E. coli) |
Cowellmedi |
Recombinant production in E. coli |
BCP (biphasic calcium phosphate) matrix |
Up to $2,000 per unit |
Available in several countries |
|
Bongros-BMP |
Human recombinant (E. coli) |
Bioalpha (Korea) |
Recombinant production in E. coli |
Combined with hydroxyapatite |
$2,500-4,500 per unit |
Limited availability in Latin America |
|
e.rh-BMP2 / BioCaP / β-TCP |
Human recombinant (E. coli) |
Shanghai Ninth People’s Hospital (China) |
Recombinant production in E. coli |
Biomimetic calcium phosphate (BioCaP/β-TCP) matrix |
Not commercially available |
Not available in Latin America |
|
e.rh-BMP2 in hydroxyapatite |
Human recombinant (E. coli) |
Geistlich Pharma |
Recombinant production in E. coli |
Hydroxyapatite and collagen matrix |
$3,500-6,000 per kit |
Available in some countries |