Table 2: Studies involving daily zinc intake in humans.

First

author,

year

Study

design

Setting

Inclusion

criteria

Exclusion

criteria

Number of

subjects

(M-F)

Lowest quintile intake/RDA or EAR

% subject

in lowest quintile

intake /

% subject

< RDA or EAR

Highest

Quintile

intake

% subject

in highest

quintile

intake

Primary

outcomes

Results

Hyun,

2004

Cohort

study

All surviving from the original Rancho Bernardo cohort who still resided in southern California

45 years

 

396 men

 

 

 

 

To examine the independent association between dietary zinc and plasma zinc and the association of each with bone mineral density (BMD)

Age- and BMI-adjusted dietary and total zinc intakes were significantly lower in the men with osteoporosis at the spine than in men without osteoporosis at that location

 

Elmstahl,

1998

population-

based

prospective

cohort

study

city of Malmo, in the southern part of Sweden

Aged

46-68 years

 

6576 men

The intakes in the lowest quintiles were 10 mg for zinc

Low zinc intake showed a threshold with increased fracture risk in the lowest decentile, corresponding to a zinc intake of 9.5 mg daily

A high proportion of the population, more than 20%, seems to be at risk of having inadequate dietary habits with respect to zinc

A lower fracture risk was noted in men with zinc intake in the second quintile [RR = 0.58 (0.34-0.99)] and fifth quintile [RR = 0.47 (0.25-0.89)] compared with the lowest decentile

 

To determine dietary risk factors for fracture in men aged 46-68 years

Inadequate intakes of zinc are important risk factors for fracture

Mahdavi-

Roshan,

2015

Cross-

sectional

study

Rheumatology clinic in Tabriz, Islamic Republic of Iran

women > 50 years old who had been no menstruation for 6 months prior to entry into the study, having no history of hormone replacement therapy, other bone disease, kidney stones, endocrine disorders or any medical conditions that could influence on the mineral status

Use of mineral supplements, having history of hormone replacement therapy, bone disease, kidney stones, endocrine disorders or any medical conditions that could influence on the mineral status

A total of 51 post-menopausal women

The mean dietary intake (and percent from RDA) of zinc in post-menopausal women with low bone density was 3.82 ± 0.19 mg/day (48 ± 2.41% RDA)

 

 

 

To investigate and compare the mineral status between osteopenic and osteoporotic postmenopausal women in Tabriz, Islamic Republic of Iran

The mean dietary intake of zinc was significantly lower than recommended dietary allowance (RDA). No statistically significant differences were observed between the osteopenic and osteoporotic groups with respect to dietary intake of zinc