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>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2017, Issue 4


Uranga-Romano JG, Hernández-Valencia M, Zárate A, Basavilvazo-Rodríguez MA
Dienogest usefulness in pelvic pain due to endometriosis. A meta-analysis of its effectiveness
Rev Med Inst Mex Seguro Soc 2017; 55 (4)

Language: Español
References: 11
Page: 452-455
PDF: 273.37 Kb.

[Full text - PDF]

ABSTRACT

Background: Endometriosis is the presence of functional endometrial tissue in the pelvic peritoneum and it affects several age groups. That is why the impact of endometriosis in quality of life is considerable. The objective of this study was to evaluate the effectiveness of dienogest in patients with pelvic pain associated to endometriosis (PPAE).
Methods: The evaluation of the effectiveness was carried out through a systematic review using the Cochrane methodology. It was used Markov model, which considers two states of health (with and without PPAE), with the possibility of weekly transition. Women between 18 and 45 years with PPAE were included, in a temporary horizon of 26 weeks. A level of statistical significance of 95% was used for a p ‹ 0.05, with a multivariate probabilistic analysis of sensibility, as well as a univariate analysis of sensibility in several scenarios.
Results: The probability that the female patient did not experience PPAE with the initial treatment was 87.91% with dienogest, 80.07% with danazol, 84.93% with medroxyprogesterone (injectable and oral) and 89.17% with gosereline. The probability that the female patient abandoned her initial treatment was 9% with dienogest, 12.07% with danazol, 9.6 and 6.75% with medroxyprogesterone injectable and oral, respectively, and 10.8 and 3.6% 3-monthly and monthly with gosereline.
Conclusion: Compared to danazol, medroxiprogesterone and gosereline, dienogest is the most efficient alternative to treat PPAE.


Key words: Endometriosis, Pelvic pain.





>Journals >Revista Médica del Instituto Mexicano del Seguro Social >Year 2017, Issue 4
 
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