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2021, Número 2

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Arch Neurocien 2021; 26 (2)


Glutamine-mediated nitric oxide synthase inhibition might explain the ‘arginine paradox’

Pérez-Neri I, Ríos-Castañeda C
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Idioma: Ingles.
Referencias bibliográficas: 18
Paginas: 7-9
Archivo PDF: 192.09 Kb.


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REFERENCIAS (EN ESTE ARTÍCULO)

  1. Flam BR, Hartmann PJ, Harrell-Booth M, Solomonson LP, Eichler DC. Caveolar localization of arginine regeneration enzymes, argininosuccinate synthase, and lyase, with endothelial nitric oxide synthase. Nitric Oxide. 2001; 5(2):187-197. DOI: 10.1006/niox.2001.0340

  2. Mathewson AM, Wadsworth RM. Induction of iNOS restricts functional activity of both eNOS and nNOS in pig cerebral artery. Nitric Oxide. 2004; 11(4):331-339. Doi: 10.1016/j. niox.2004.10.006

  3. Gornik HL, Creager MA. Arginine and endothelial and vascular health. J Nutr. 2004;134(S10):2880S-2887S; discussion 2895S. DOI: 10.1093/jn/134.10.2880S

  4. Salter M, Duffy C, Garthwaite J, Strijbos PJ. Ex vivo measurement of brain tissue nitrite and nitrate accurately reflects nitric oxide synthase activity in vivo. J Neurochem. 1996; 66(4):1683-1690. DOI: 10.1046/j.1471-4159.1996.66041683.x

  5. Lee J, Ryu H, Ferrante RJ, Morris SM, Ratan RR. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A. 2003;100(8):4843- 4848. DOI: 10.1073/pnas.0735876100

  6. Morris Jr SM. Enzymes of arginine metabolism. J Nutr. 2004;134(10):2743S-2747S. DOI: 10.1093/jn/134.10.2743S

  7. Pérez-Neri I, Ramírez-Bermúdez J, Ojeda-López C, Montes S, Soto-Hernández JL, Ríos C. Las concentraciones de glutamina y citrulina reflejan la síntesis del óxido nítrico en el sistema nervioso humano. Neurología. 2020;35(2):96-104. DOI: 10.1016/j. nrl.2017.07.013

  8. Shin S, Mohan S, Fung HL. Intracellular L-arginine concentration does not determine NO production in endothelial cells: implications on the “L-arginine paradox”. Biochem Biophys Res Commun. 2011; 414(4):660-663. Doi: 10.1016/j. bbrc.2011.09.112

  9. Aisaka K, Gross SS, et al. L-arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo. Biochem Biophys Res Commun. 1989;163(2):710-717. https://doi. org/10.1016/0006-291X(89)92281-X

  10. Gold ME, Bush PA, Ignarro LJ. Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation. Biochem Biophys Res Commun. 1989;164(2):714-721. DOI: 10.1016/0006-291x(89)91518-0

  11. Ogawa T, Kimoto M, Sasaoka K. Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney. J Biol Chem. 1989;264(17):10205-10209.

  12. Tsikas D, Böger RH, Sandmann J, Bode-Böger SM, Frölich JC. Endogenous nitric oxide synthase inhibitors are responsible for the L-arginine paradox. FEBS Lett. 2000;478(1-2):1-3. DOI: 10.1016/s0014-5793(00)01686-0

  13. Closs EI, Scheld JS, Sharafi M, Förstermann U. Substrate supply for nitric-oxide synthase in macrophages and endothelial cells: role of cationic amino acid transporters. Mol Pharmacol. 2000;57(1):68-74.

  14. Arnal JF, Münzel T, Venema RC, James NL, Bai CL, Mitch WE et al. Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability. J Clin Invest. 1995;95(6):2565-2572. DOI: 10.1172/JCI117957

  15. Bryk J, Ochoa JB, Correia MI, Munera-Seeley V, Popovic PJ. Effect of citrulline and glutamine on nitric oxide production in RAW 264.7 cells in an arginine-depleted environment. J Parenter Enteral Nutr. 2008;32(4):377-383. DOI: 10.1177/0148607108319807

  16. Rochette L, Lorin J, Zeller M, Guilland JC, Lorgis L, Cottin Y et al. Nitric oxide synthase inhibition and oxidative stress in cardiovascular diseases: possible therapeutic targets. Pharmacol Ther. 2013;140(3):239-257. DOI: 10.1016/j.pharmthera.2013.07.004

  17. Gambardella J, Khondkar W, Morelli MB, Wang X, Santulli G, Trimarco V. Arginine and Endothelial Function. Biomedicines. 2020;8:277. https:// doi.org/10.3390/biomedicines8080277

  18. Durante W. The Emerging Role of l-Glutamine in Cardiovascular Health and Disease. Nutrients. 2019;11(9) DOI: 10.3390/nu11092092




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