Pérez EB, Rivera MR

Idioma: Español
Referencias bibliográficas: 17
Paginas: 89-93
Archivo PDF: 146.54 Kb.

RESUMEN

La galectina 3 es una lectina que tiene funciones intra y extracelulares. Su expresión se suprarregula en la transformación neoplásica de las células del epitelio folicular tiroideo. Su identificación mediante inmunohistoquímica en tejidos y biopsias por aspiración de lesiones tiroideas brinda una alternativa de utilidad significativa para el diagnóstico preoperatorio del carcinoma folicular de tiroides.

REFERENCIAS (EN ESTE ARTÍCULO)

1. Barondes SH, Cooper DNW, Gitt MA, Leffler H. Galectins:structure and function of a large family of lectins. J BiolChem 1994; 269: 20807-10.

2. Cooper DNW, Barondes SH. 1999. God must love galectins;he made so many of them. Glycobiology 1999; 9: 979-84.

3. Yang R-Y, Hsu DK, Yu L, Ni J, Liu F-T. Cell cycle regulation bygalectin-12, a new member of the galectin superfamily. JBiol Chem 2001; 276: 20252-60.

4. Sano H, Hsu DK, Yu L et al. Human galectin-3 is a novelchemoattractant for monocytes and macrophages. JImmunol 2000; 165: 2156-64.

5. Kawachi K, Matsushita Y, Yonezawa S et al. Galectin-3expression in various thyroid neoplasms and its possible rolein metastasis formation. Hum Pathol 2000; 31: 428-33.

6. Raber W, Kaserer K, Niederle B, Vierhapper H. Risk factorsfor malignancy of thyroid nodules initially identified asfollicular neoplasia by fine-needle aspiration: results of aprospective study of one hundred twenty patients. Thyroid2000; 10: 709-12.

7. Schlinkert RT, van Heerden JA, Goellner JR et al. Factorsthat predict malignant thyroid lesions when fine-needleaspiration is “suspicious for follicular neoplasm”. Mayo ClinProc. 1997; 72: 913-6.

8. Xu XC, Nl-Naggar AK, Lotan R. Differential expression ofgalectin-1 and galectin-3 in thyroid tumors: potentialdiagnostic implications. Am J Pathol 1995; 147: 815-22.

9. Fernández PL, Merino MJ, Gómez M et al. Galectin-3 andlaminin expression in neoplastic and non-neoplastic thyroidtissue. J Pathol 1997; 181: 80-6.

10. Orlandi F, Saggiorato E, Pivano G et al. Galectin-3 is apresurgical marker of human thyroid carcinoma. Cancer Res1998; 58: 3015-20.

11. Cvejic D, Savin S, Paunovic I et al. Immunohistochemicallocalization of galectin-3 in malignant and benign humanthyroid tissue. Anticancer Res 1998; 18: 2637-41.

12. Inohara H, Honjo Y, Yoshii T et al. Expression of galectin-3in fine-needle aspirates as a diagnostic marker differentiatingbenign from malignant thyroid neoplasms. Cancer1999; 85: 2475-84.

13. Nascimento MC, Bisi H, Alves VA et al. Differential reactivityfor galectin-3 in Hürthle cell adenoma and carcinomas.Endocr Pathol 2001; 12: 275-9.

14. Saggiorato E, Cappia S, de Giuli P. Galectin-3 as apresurgical immunocytodiagnostic marker of minimallyinvasive follicular thyroid carcinoma. J Clin Endocrinol Metab2001; 86: 5152-8.

15. Mizukami Y, Nonomura A, Hayashi Y et al. Late bonemetastasis from an encapsulated follicular carcinoma of thethyroid without capsular and vascular invasion. Pathol Int1996; 46: 457-61.

16. Hirai K, Kotani T, Aratake Y, Ohtaki S, Kuma K. Dipeptidylpeptidase IV (DPP IV/CD26) staining predicts distantmetastasis of “benign” thyroid tumor. Pathol Int 1999; 49:264-5.

17. Bartolazzi A, Gasberri A, Papotti M et al. Application of animmunodiagnostic method for improving preoperative diagnosisof nodular thyroid lesions. Lancet 2001; 357: 1644-50.