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Revista Mexicana de Trastornos Alimentarios

2022, Número 1

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Revista Mexicana de Trastornos Alimentarios 2022; 12 (1)


Neurobiología, Temperamento y nuevos enfoques en el tratamiento de la Anorexia Nerviosa del adulto

Gempeler RJ, Rodríguez GM

Idioma: Español
Referencias bibliográficas: 86
Paginas: 88-104
Archivo PDF: 307.27 Kb.


RESUMEN

El curso crónico, y la tendencia a la recaída, así como la escasa utilidad de los medicamentos y los resultados parciales de la psicoterapia en pacientes con Anorexia Nerviosa (AN), sigue siendo un reto para los clínicos. El reto es aún mayor con aquellos pacientes con AN severa y duradera ( adultos mayores de 25 años, con un curso crónico de la enfermedad). Los conocimientos acerca de la neurobiología y el papel de los rasgos del temperamento en la aparición y mantenimiento de los síntomas en el tiempo han tenido avances significativos en los últimos años. objetivo fue realizar una revisión narrativa de artículos publicados en los últimos años que abordan el tema de las bases neurobiológicas de la AN, los rasgos característicos del temperamento y su incorporación en los nuevos enfoques terapéuticos para pacientes adultos con AN. Se describen los principales modelos terapéuticos que integran la neurobiología y el temperamento y se discute la evidencia científica de eficacia y efectividad de estos. Se concluye, que aunque la brecha entre investigación y aplicaciones terapéuticas derivadas de este cuerpo de conocimientos sigue siendo todavía muy amplia, los avances son muy prometedores.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. American Psychiatric Association, DSM-5 Task Force.(2013). Diagnostic and statistical manual ofmental disorders: DSM-5TM (5th ed.). American PsychiatricPublishing, Inc.. https://doi.org/10.1176/appi.books.9780890425596

  2. Atiye, M., Miettunen, J., & Raevuori-Helkamaa, A. (2015).A meta-analysis of temperament in eating disorders.European eating disorders review: the journal of theEating Disorders Association, 23(2), 89-99. https://doi.org/10.1002/erv.2342

  3. Attia, E. (2021) Anorexia nervosa treatment trials: time fornew approaches. Lancet Psychiatry, 8(3), 170-171. https://doi.org/10.1016/S2215-0366(21)00038-9

  4. Bang, L., Treasure, J., Rø, Ø., & Joos, A. (2017). Advancingour understanding of the neurobiology ofanorexia nervosa: translation into treatment. Journalof eating disorders, 5(38). https://doi.org/10.1186/s40337-017-0169-8

  5. Baumann, S., Mareš, T., Albrecht, J., Anders, M., Vochosková,K., Hill, M., Bulant, J., Yamamotová, A., Štastný, O.,Novák, T., Holanová, P., Lambertová, A., & Papežová,H. (2021). Effects of Transcranial Direct Current StimulationTreatment for Anorexia Nervosa. Frontiersin psychiatry, 12, 717255. https://doi.org/10.3389/fpsyt.2021.717255

  6. Bernardoni, F., King, J.A., Geisler, D., Stein, E., Jaite, C.,Natsch, D., Tam, F.I., Boehm, I., Seidel, M., Roessner,V., & Ehrlich, S. (2016). Weight restoration therapy rapidlyreverses cortical thinning in anorexia nervosa: Alongitudinal study. Neuroimage, 130, 212-222. https://doi.org/10.1016/j.neuroimage.2016.02.003

  7. Berner, L. A., Simmons, A. N., Wierenga, C. E., Bischoff-Grethe, A., Paulus, M. P., Bailer, U. F., Ely, A. V., &Kaye, W. H. (2018). Altered interoceptive activation before,during, and after aversive breathing load in womenremitted from anorexia nervosa. Psychological medicine,48(1), 142–154.

  8. Bischoff-Grethe, A., McCurdy, D., Grenesko-Stevens, E., Irvine,L. E., Wagner, A., Yau, W. Y., Fennema-Notestine,C., Wierenga, C. E., Fudge, J. L., Delgado, M. R., &Kaye, W. H. (2013). Altered brain response to rewardand punishment in adolescents with anorexia nervosa.Psychiatry research, 214(3), 331–340. https://doi.org/10.1016/j.pscychresns.2013.07.004

  9. Brockmeyer, T., Ingenerf, K., Walther, S., Wild, B., Hartmann,M., Herzog, W., Bents, H., & Friederich, H. C.(2014). Training cognitive flexibility in patients withanorexia nervosa: a pilot randomized controlled trialof cognitive remediation therapy. The Internationaljournal of eating disorders, 47(1), 24–31. https://doi.org/10.1002/eat.22206

  10. Brockmeyer, T., Schmidt, H., Leiteritz-Rausch, A., Zimmermann,J., Wünsch-Leiteritz, W., Leiteritz, A., &Friederich, H. C. (2021). Cognitive remediation therapyin anorexia nervosa-A randomized clinical trial. Journalof consulting and clinical psychology, 89(10), 805–815.https://doi.org/10.1037/ccp0000675

  11. Brockmeyer, T., Febry, H., Leiteritz-Rausch, A., Wünsch-Leiteritz,W., Leiteritz, A., & Friederich, H. C. (2022).Cognitive flexibility, central coherence, and quality of lifein anorexia nervosa. Journal of eating disorders, 10(1),22. https://doi.org/10.1186/s40337-022-00547-4

  12. Brodrick, B. B., Adler-Neal, A. L., Palka, J. M., Mishra, V.,Aslan, S., & McAdams, C. J. (2021). Structural braindifferences in recovering and weight-recovered adultoutpatient women with anorexia nervosa. Journal ofeating disorders, 9(1), 108. https://doi.org/10.1186/s40337-021-00466-w

  13. Broomfield, C., Stedal, K., & Touyz, S. (2021). The neuropsychologicalprofile of severe and enduring anorexianervosa: A systematic review. Frontiers in psychology, 12,708536. https://doi.org/10.3389/fpsyg.2021.708536

  14. Cassin, S., & von Ranson, K. (2005). Personality and eatingdisorders: A decade in review. Clinical PsychologyReview, 25,(7) 895–916. https://doi.org/10.1016/j.cpr.2005.04.012

  15. Dahlgren, C. L., & Rø, Ø. (2014). A systematic review ofcognitive remediation therapy for anorexia nervosa:Development, current state and implications for futureresearch and clinical practice. Journal of EatingDisorders, 2(26), 1–11. https://doi.org/10.1186/s40337-014-0026-y

  16. Dalton, B., Maloney, E., Rennalls, S. J., Bartholdy, S., Kekic,M., McClelland, J., Campbell, I. C., Schmidt, U., &O’Daly, O. G. (2021). A pilot study exploring the effectof repetitive transcranial magnetic stimulation (rTMS)treatment on cerebral blood flow and its relation toclinical outcomes in severe enduring anorexia nervosa.Journal of eating disorders, 9(1), 84. https://doi.org/10.1186/s40337-021-00420-w

  17. Dandil, Y., Smith, K., Adamson, J., & Tchanturia, K. (2020).Individual cognitive remediation therapy benefits forpatients with anorexia nervosa and high autistic features.European eating disorders review: the journal of theEating Disorders Association, 28(1), 87–91. https://doi.org/10.1002/erv.2707

  18. DeGuzman, M., Shott, M. E., Yang, T. T., Riederer, J., &Frank, G. (2017). Association of Elevated Reward PredictionError Response with Weight Gain in AdolescentAnorexia Nervosa.The American journal of psychiatry,174(6), 557–565. https://doi.org/10.1176/appi.ajp.2016.16060671

  19. Dingemans, A. E., Danner, U. N., Donker, J. M., Aardoom,J. J., van Meer, F., Tobias, K., & van Furth, E.F. (2014). The effectiveness of cognitive remediationtherapy in patients with a severe or enduring eatingdisorder: A randomized controlled trial. Psychotherapyand Psy-chosomatics, 83(1), 29–36. https://doi.org/10.1159/000355240

  20. Duriez, P., Bou Khalil, R., Chamoun, Y., Maatoug, R.,Strumila, R., Seneque, M., Gorwood, P., Courtet, P., &Guillaume, S. (2020). Brain stimulation in eating disorders:State of the art and future perspectives. Journal ofclinical medicine, 9(8), 2358. https://doi.org/10.3390/jcm9082358

  21. Foerde, K., & Steinglass, J. E. (2017). Decreased feedbacklearning in anorexia nervosa persists after weight restoration.The International journal of eating disorders,50(4), 415–423. https://doi.org/10.1002/eat.22709

  22. Frank, G., Roblek, T., Shott, M., Jappe, L., Rollin, M.,Hagman, J., & Pryor, T. (2012). Heightened fear ofuncertainty in anorexia and bulimia nervosa. The InternationalJournal of Eating Disorders, 45(2), 227–232.https://doi.org/10.1002/eat.20929

  23. Frank, G., Shott, M. E., & DeGuzman, M. C. (2019). TheNeurobiology of Eating Disorders. Child and adolescentpsychiatric clinics of North America, 28(4), 629–640.https://doi.org/10.1016/j.chc.2019.05.007

  24. Franko, D. L., Keshaviah, A., Eddy, K. T., Krishna, M.,Davis, M. C., Keel, P. K., & Herzog, D. B. (2013). A longitudinalinvestigation of mortality in anorexia nervosaand bulimia nervosa.The American journal of psychiatry,170(8), 917–925. https://doi.org/10.1176/appi.ajp.2013.12070868

  25. Giombini, L., Nesbitt, S., Kusosa, R., Fabian, C., Sharia, T.,Easter, A., & Tchanturia, K. (2022). Neuropsychologicaland clinical findings of cognitive remediation therapyfeasibility randomized controlled trial in young peoplewith anorexia nervosa. European eating disorders review:the journal of the Eating Disorders Association,30(1), 50–60. https://doi.org/10.1002/erv.2874

  26. Harrison, A., O’Brien, N., Lopez, C., & Treasure, J. (2010).Sensitivity to reward and punishment in eating disorders.Psychiatry research, 177(1-2), 1–11. https://doi.org/10.1016/j.psychres.2009.06.010

  27. Harrison, A., Stavri, P., Ormond, L., McEnemy, F., Akyol,D., Qureshi, A., & Al-Khairulla, H. (2018). Cognitiveremediation therapy for adolescent inpatients with severeand complex anorexia nervosa: A treatment trial.European eating disorders review: the journal of theEating Disorders Association, 26(3), 230–240. https://doi.org/10.1002/erv.2584

  28. Herpertz, S., Hagenah, U., Vocks, S., von Wietersheim,J., Cuntz, U., Zeeck, A., German Society of PsychosomaticMedicine and Psychotherapy, & GermanCollege for Psychosomatic Medicine (2011). The diagnosisand treatment of eating disorders. DeutschesArzteblatt international, 108(40), 678–685. https://doi.org/10.3238/arztebl.2011.0678

  29. Hill, L., Peck, S. K., Wierenga, C. E., & Kaye, W. H. (2016).Applying neurobiology to the treatment of adults withanorexia nervosa. Journal of eating disorders, 4, 31. https://doi.org/10.1186/s40337-016-0119-x

  30. Joos, A. A., Saum, B., van Elst, L. T., Perlov, E., Glauche,V., Hartmann, A., Freyer, T., Tüscher, O., & Zeeck, A.(2011). Amygdala hyperreactivity in restrictive anorexianervosa. Psychiatry research, 191(3), 189–195. https://doi.org/10.1016/j.pscychresns.2010.11.008

  31. Kaye, W. H., Wierenga, C. E., Knatz, S., Liang, J., Boutelle,K., Hill, L., & Eisler, I. (2015). Temperament-basedtreatment for anorexia nervosa.European eating disordersreview: the journal of the Eating DisordersAssociation, 23(1), 12–18. https://doi.org/10.1002/erv.2330

  32. Keegan, E., Tchanturia, K., & Wade, T. D. (2021) Central coherenceand set-shifting between nonunderweight eatingdisorders and anorexia nervosa: A systematic reviewand meta-analysis. The International Journal of EatingDisorders, 54(3), 229-243. https://doi.org/10.1002/eat.23430

  33. Klump, K. L., Bulik, C. M., Pollice, C., Halmi, K. A., Fichter,M. M., Berrettini, W. H., Devlin, B., Strober, M.,Kaplan, A., Woodside, D. B., Treasure, J., Shabbout,M., Lilenfeld, L. R., Plotnicov, K. H., & Kaye, W. H.(2000). Temperament and character in women withanorexia nervosa. The Journal of nervous and mentaldisease, 188(9), 559–567.

  34. Knatz S., Towne, T., Wierenga, C. E., Hill, L., Eisler, I.,Brown, T., Han, E., Miller, M., Perry, T., & Kaye, W.(2021). Temperament-based treatment for young adultswith eating disorders: acceptability and initial efficacyof an intensive, multi-family, parent-involved treatment.Journal of eating disorders, 9(1), 110. https://doi.org/10.1186/s40337-021-00465-x

  35. Knatz, S., Wierenga, C. E., Murray, S. B., Hill, L., & Kaye,W. H. (2015). Neurobiologically informed treatmentfor adults with anorexia nervosa: a novel approachto a chronic disorder. Dialogues in clinical neuroscience,17(2), 229–236. https://doi.org/10.31887/DCNS.2015.17.2/sknatz

  36. Knyahnytska, Y. O., Blumberger, D. M., Daskalakis, Z. J.,Zomorrodi, R., & Kaplan, A. S. (2019). Insula H-coildeep transcranial magnetic stimulation in severe andenduring anorexia nervosa (SE-AN): a pilot study. Neuropsychiatricdisease and treatment, 15, 2247–2256.https://doi.org/10.2147/NDT.S207630

  37. Lilenfeld, L. (2011). Personality and temperament. CurrentTopics in Behavioural Neuroscience, 6, 3–9. https://doi.org/10.1007/7854_ 2010_86

  38. Lipsman, N., Lam, E., Volpini, M., Sutandar, K., Twose,R., Giacobbe, P., Sodums, D. J., Smith, G. S., Woodside,D. B., & Lozano, A. M. (2017). Deep brain stimulationof the subcallosal cingulate for treatment-refractoryanorexia nervosa: 1 year follow-up of an open-labeltrial. The lancet Psychiatry, 4(4), 285–294. https://doi.org/10.1016/S2215-0366(17)30076-7

  39. Liu, W., Zhan, S., Li, D., Lin, Z., Zhang, C., Wang, T., Pan,S., Zhang, J., Cao, C., Jin, H., Li, Y., & Sun, B. (2020).Deep brain stimulation of the nucleus accumbens fortreatment-refractory anorexia nervosa: A long-termfollow-up study. Brain stimulation, 13(3), 643–649. https://doi.org/10.1016/j.brs.2020.02.004

  40. Lopez, C., Tchanturia, K., Stahl, D., Booth, R., Holliday,J., & Treasure, J. (2008). An examination of the conceptof central coherence in women with anorexia nervosa.The International journal of eating disorders, 41(2),143–152. https://doi.org/10.1002/eat.20478

  41. Lopez, C., Tchanturia, K., Stahl, D., & Treasure, J. (2008).Central coherence in women with bulimia nervosa. InternationalJournal of Eating Disorders, 41(4), 340-347..https://doi.org/10.1002/eat.20511

  42. McClelland, J., Kekic, M., Campbell, I. C., & Schmidt, U.(2016). Repetitive Transcranial Magnetic Stimulation(rTMS) treatment in enduring anorexia nervosa: A CaseSeries. European eating disorders review : the journalof the Eating Disorders Association, 24(2), 157–163. https://doi.org/10.1002/erv.2414

  43. Miyake, Y., Okamoto, Y., Onoda, K., Shirao, N., Okamoto,Y., Otagaki, Y., & Yamawaki, S. (2010). Neural processingof negative word stimuli concerning body imagein patients with eating disorders: An fMRI study. NeuroImage,50, 1333-1339. https://doi.org/10.1016/j.neuroimage.2009.12.095

  44. Muratore, A. F., & Attia, E. (2021). Current therapeuticapproaches to anorexia nervosa: State of the art. Clinicaltherapeutics, 43(1), 85–94. https://doi.org/10.1016/j.clinthera.2020.11.006

  45. Murray, S. B., Strober, M., Tadayonnejad, R., Bari, A. A.,& Feusner, J. D. (2022). Neurosurgery and neuromodulationfor anorexia nervosa in the 21st century: asystematic review of treatment outcomes. Eating disorders,30(1), 26–53. https://doi.org/10.1080/10640266.2020.1790270

  46. Oberndorfer, T. A., Frank, G. K., Simmons, A. N., Wagner,A., McCurdy, D., Fudge, J. L.,Yang, T.T.,Paulus, M.P., &Kaye, W. H. (2013). Altered insula response to sweet tasteprocessing after recovery from anorexia and bulimianervosa. The American journal of psychiatry, 170(10),1143–1151. doi:10.1176/appi.ajp.2013.11111745

  47. Oudijn, M. S., Mocking, R., Wijnker, R. R., Lok, A., Schuurman,P. R., van den Munckhof, P., van Elburg, A. A., &Denys, D. (2021). Deep brain stimulation of the ventralanterior limb of the capsula interna in patients withtreatment-refractory anorexia nervosa. Brain stimulation,14(6), 1528–1530. https://doi.org/10.1016/j.brs.2021.10.387

  48. Papadopoulos, F. C., Ekbom, A., Brandt, L., & Ekselius, L.(2009). Excess mortality, causes of death and prognosticfactors in anorexia nervosa. The British journal of psychiatry: the journal of mental science, 194(1), 10–17.https://doi.org/10.1192/bjp.bp.108.054742

  49. Park, R. J., Singh, I., Pike, A. C., & Tan, J. O. (2017). DeepBrain Stimulation in Anorexia Nervosa: Hope for theHopeless or Exploitation of the Vulnerable? The OxfordNeuroethics Gold Standard Framework. Frontiers in psychiatry,8, 44. https://doi.org/10.3389/fpsyt.2017.00044

  50. Paslakis, G., Scholz-Hehn, A. D., Sommer, L. M., &Kühn, S. (2021). Implicit bias to food and body cues ineating disorders: a systematic review. Eating and weightdisorders : EWD, 26(5), 1303–1321. https://doi.org/10.1007/s40519-020-00974-9

  51. Ralph-Nearman, C., Achee, M., Lapidus, R., Stewart, J.L., & Filik, R. (2019). A systematic and methodologicalreview of attentional biases in eating disorders: Food,body, and perfectionism. Brain and behavior, 9(12),e01458. https://doi.org/10.1002/brb3.1458

  52. Raney T. J., Thornton L. M., Berrettini W., Brandt H.,Crawford S., ... Fichter, M. M. (2008). Influence ofoveranxious disorder of childhood on the expression ofanorexia nervosa. The International Journal of EatingDisorders, 41(4), https://doi.org/10.1002/eat.20508

  53. Sanders, N., Smeets, P.A.M., vanElburg, A.A., Danner, U.N.,vanMeer, F., ... Hoek, H. W. (2015). Altered food-cueprocessing in chronically ill and recovered women withanorexia nervosa. Frontiers in Behavioral Neuroscience2015; 9:46.

  54. Scharner, S., & Stengel, A. (2019). Alterations of brain structureand functions in anorexia nervosa, Clinical NutritionExperimental, 28, 22-32. https://doi.org/10.1016/j.yclnex.2019.02.001

  55. Schmidt, U., & Campbell, I. (2013). Treatment of eatingdisorders cannot remain ‘brainless’: The case for brain-directed treatments. European Eating DisordersReview, 21, 425–427. doi: 10.1002/ erv.2257

  56. Schmidt, U., Magill, N., Renwick, B., Keyes, A., Kenyon,M., Dejong, H., Lose, A., Broadbent, H., Loomes, R.,Yasin, H., Watson, C., Ghelani, S., Bonin, E. M., Serpell,L., Richards, L., Johnson-Sabine, E., Boughton,N., Whitehead, L., Beecham, J., Treasure, J., ... Landau,S. (2015). The Maudsley Outpatient Study of Treatmentsfor Anorexia Nervosa and Related Conditions(MOSAIC): Comparison of the Maudsley Model ofAnorexia Nervosa Treatment for Adults (MANTRA)with specialist supportive clinical management (SSCM)in outpatients with broadly defined anorexia nervosa:A randomized controlled trial. Journal of consultingand clinical psychology, 83(4), 796–807. https://doi.org/10.1037/ccp0000019

  57. Schmidt, U., Renwick, B., Lose, A., Kenyon, M., Dejong,H., Broadbent, H., Loomes, R., Watson, C., Ghelani,S., Serpell, L., Richards, L., Johnson-Sabine, E., Boughton,N., Whitehead, L., Beecham, J., Treasure, J., &Landau, S. (2013). The MOSAIC study - comparisonof the Maudsley model of treatment for adults withanorexia nervosa (MANTRA) with specialist supportiveclinical management (SSCM) in outpatients withanorexia nervosa or eating disorder not otherwisespecified, anorexia nervosa type: study protocol for arandomized controlled trial. Trials, 14, 160. https://doi.org/10.1186/1745-6215-14-160

  58. Schmidt, U., Ryan, E. G., Bartholdy, S., Renwick, B., Keyes,A., O’Hara, C., McClelland, J., Lose, A., Kenyon,M., Dejong, H., Broadbent, H., Loomes, R., Serpell,L., Richards, L., Johnson-Sabine, E., Boughton, N.,Whitehead, L., Bonin, E., Beecham, J., Landau, S., ...Treasure, J. (2016). Two-year follow-up of the MOSAICtrial: A multicenter randomized controlled trial comparingtwo psychological treatments in adult outpatientswith broadly defined anorexia nervosa. The Internationaljournal of eating disorders, 49(8), 793–800. https://doi.org/10.1002/eat.22523

  59. Schmidt, U., & Treasure, J. (2006). Anorexia nervosa: valuedand visible. A cognitive-interpersonal maintenance modeland its implications for research and practice. TheBritish journal of clinical psychology, 45(Pt 3), 343–366.https://doi.org/10.1348/014466505x53902

  60. Schmidt, U., Wade, T. D., & Treasure, J. (2014). The Maudsleymodel of anorexia nervosa treatment for adults(MANTRA): Development, key features, and preliminaryevidence.Journal of cognitive psychotherapy,28(1),48–71. https://doi.org/10.1891/0889-8391.28.1.48

  61. Sfärlea, A., Lukas, L., Schulte-Körne, G., & Platt, B. (2021).The KOALA-study: study protocol for a comprehensivestudy of cognitive biases in adolescent anorexianervosa patients compared to healthy and clinical controls.Journal of eating disorders, 9(1), 139. https://doi.org/10.1186/s40337-021-00494-6

  62. Sobstyl, M., Stapińska-Syniec, A., Sokół-Szawłowska, M., &Kupryjaniuk, A. (2019). Deep brain stimulation for thetreatment of severe intractable anorexia nervosa. Britishjournal of neurosurgery, 33(6), 601–607. https://doi.org/10.1080/02688697.2019.1667484

  63. Solmi, M., Wade, T. D., Byrne, S., Del Giovane, C., Fairburn,C. G., Ostinelli, E. G., De Crescenzo, F., Johnson,C., Schmidt, U., Treasure, J., Favaro, A., Zipfel, S., &Cipriani, A. (2021). Comparative efficacy and acceptabilityof psychological interventions for the treatmentof adult outpatients with anorexia nervosa: a systematicreview and network meta-analysis. The lancetPsychiatry, 8(3), 215–224. https://doi.org/10.1016/S2215-0366(20)30566-6

  64. Sproch, L. E., Anderson, K. P., Sherman, M. F., Crawford,S. F., & Brandt, H. A. (2019). A randomized controlledtrial of group cognitive remediation therapy for anorexianervosa: Effects on set-shifting tasks for inpatient adultsand adolescents. The International journal of eatingdisorders, 52(9), 1004–1014. https://doi.org/10.1002/eat.23143

  65. Steinglass, J. E., Berner, L. A., & Attia, E. (2019). Cognitiveneuroscience of eating disorders. The Psychiatricclinics of North America, 42(1), 75–91. https://doi.org/10.1016/j.psc.2018.10.008

  66. Steinglass, J. E., Dalack, M., & Foerde, K. (2019). The promiseof neurobiological research in anorexia nervosa.Current opinion in psychiatry, 32(6), 491–497. https://doi.org/10.1097/YCO.0000000000000540

  67. Steinglass, J. E., & Walsh, B. T. (2016). Neurobiologicalmodel of the persistence of anorexia nervosa. Journalof eating disorders, 4, 19. https://doi.org/10.1186/s40337-016-0106-2

  68. Steinglass, J. E., Walsh, B. T., & Stern, Y. (2006). Set shiftingdeficit in anorexia nervosa. Journal of the InternationalNeuropsychological Society : JINS, 12(3), 431–435. https://doi.org/10.1017/s1355617706060528

  69. Stiles-Shields, C,. Bamford, BH,. Touyz, S,. Le Grange, D,.Hay, P,. & Lacey, H. (2016) Predictors of therapeuticalliance in two treatments for adults with severe andenduring anorexia nervosa. The International Journalof Eating Disorders, Apr, 5(4), 13 https://doi.org/10.1186/s40337-016-0102-6

  70. Su, T., Gong, J., Tang, G., Qiu, S., Chen, P., Chen, G.,Wang, J., Huang, L., & Wang, Y. (2021). Structuraland functional brain alterations in anorexia nervosa:Amultimodal meta-analysis of neuroimaging studies. Humanbrain mapping, 42(15), 5154–5169. https://doi.org/10.1002/hbm.25602

  71. Tchanturia, K., Giombini, L., Leppanen, J., & Kinnaird, E.(2017). Evidence for cognitive remediation therapy inyoung people with anorexia nervosa: Systematic reviewand meta-analysis of the literature. European EatingDisorders Review, 25, 227–236. https://doi.org/10.1002/erv.2522

  72. Tchanturia, K., & Lock, J. (2011). Cognitive remediationtherapy for eating disorders: development,refinement and future directions. Current topics inbehavioral neurosciences, 6, 269–287. https://doi.org/10.1007/7854_2010_90

  73. Tchanturia, K., Whitney, J., & Treasure, J. (2006). Can cognitiveexercises help treat anorexia nervosa?. Eating andweight disorders: EWD, 11(4), e112–e116. https://doi.org/10.1007/BF03327574

  74. Touyz, S., Le Grange, D., Lacey, H., Hay, P., Smith, R.,... Maguire, S. (2013). Treating severe and enduringanorexia nervosa: A randomized controlled trial. PsychologicalMedicine, 43(12), 2501–2511. https://doi.org/10.1017/S0033291713000949

  75. Treasure, J., Zipfel, S., Micali, N., Wade, T., Stice, E., Claudino,A., Schmidt, U., Frank, G.K., Bulik, C.M., &Wentz, E. (2015). Anorexia nervosa. Nature Reviews.Disease Primers, 1: 15074.

  76. Van Passel, B., Danner, U. N., Dingemans, A. E., Aarts, E.,Sternheim, L. C., Becker, E. S., van Elburg, A. A., vanFurth, E. F., Hendriks, G. J., & Cath, D. C. (2020). Cognitiveremediation therapy does not enhance treatmenteffect in obsessive-compulsive disorder and anorexianervosa: A randomizedcControlled trial.Psychotherapyand psychosomatics, 89(4), 228–241. https://doi.org/10.1159/000505733

  77. Villalba Martínez, G., Justicia, A., Salgado, P., Ginés, J. M.,Guardiola, R., Cedrón, C., Polo, M., Delgado-Martí-nez, I., Medrano, S., Manero, R. M., Conesa, G., Faus,G., Grau, A., Elices, M., & Pérez, V. (2020). A Randomizedtrial of deep brain stimulation to the subcallosalcingulate and nucleus accumbens in patients with treatment-refractory, chronic, and severe anorexia nervosa:Initial results at 6 months of follow up. Journal of clinicalmedicine, 9(6), 1946. https://doi.org/10.3390/jcm9061946

  78. Wagner, A., Aizenstein, H., Venkatraman, V. K., Bischoff-Grethe, A., Fudge, J., May, J. C., Frank, G. K., Bailer,U. F., Fischer, L., Putnam, K., & Kaye, W. H. (2010). Alteredstriatal response to reward in bulimia nervosa afterrecovery. The International journal of eating disorders,43(4), 289–294. https://doi.org/10.1002/eat.20699

  79. Wagner, A., Barbarich, N., Frank, G., Bailer, U., Weissfeld,L., Henry, S., et al. (2006). Personality traits afterrecovery from eating disorders: Do subtypes differ? InternationalJournal of Eating Disorders, 39, 276–284.https://doi.org/10.1002/eat.20251

  80. Walsh B. T. (2013). The enigmatic persistence of anorexianervosa. The American journal of psychiatry,170(5), 477–484. https://doi.org/10.1176/appi.ajp.2012.12081074

  81. Watson, H., & Bulik, C. (2012). Update on the treatmentof anorexia nervosa: review of clinical trials, practiceguidelines and emerging Temperament-basedTreatment for Anorexia interventions. PsychologicalMedicine, 43, 2477–2500. https://doi.org/10.1017/S0033291712002620

  82. Wierenga, C. E., Ely, A., Bischoff-Grethe, A., Bailer, U. F.,Simmons, A. N., & Kaye, W. H. (2014). Are Extremesof Consumption in Eating Disorders Related to anAltered Balance between Reward and Inhibition? Frontiersin behavioral neuroscience, 8, 410. https://doi.org/10.3389/fnbeh.2014.00410

  83. Wierenga, C.E., Hill, L.L., Peck, S.K., McCray, J., Greathouse,L., Peterson, D., Scott, A., Eisler, I., & Kaye,W.H. (2018). The acceptability, feasibility, and possiblebenefits of a neurobiologically-informed 5-day multifamilytreatment for adults with anorexia nervosa. TheInternational journal of eating disorders, 51(8), 863-869.

  84. Wittek, T., Truttmann, S., Zeiler, M., Philipp, J., Auer-Welsbach,E., Koubek, D., Ohmann, S., Werneck-Rohrer,S., Sackl-Pammer, P., Schöfbeck, G., Mairhofer, D.,Kahlenberg, L., Schmidt, U., Karwautz, A., & Wagner,G. (2021). The Maudsley model of anorexia nervosatreatment for adolescents and young adults (MANTRa):a study protocol for a multi-center cohort study. Journalof eating disorders, 9(1), 33. https://doi.org/10.1186/s40337-021-00387-8

  85. Whiting, A. C., Oh, M. Y., & Whiting, D. M. (2018).Deep brain stimulation for appetite disorders: a review.Neurosurgical focus, 45(2), E9. https://doi.org/10.3171/2018.4.FOCUS18141

  86. Woodside, D. B., Dunlop, K., Sathi, C., Lam, E., McDonald,B., & Downar, J. (2021). A pilot trial of repetitivetranscranial magnetic stimulation of the dorsomedialprefrontal cortex in anorexia nervosa: resting fMRI correlatesof response. Journal of eating disorders, 9(1),52. https://doi.org/10.1186/s40337-021-00411-x




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