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Instituto Nacional de Salud Pública

2023, Número 2

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salud publica mex 2023; 65 (2)


Antígeno de membrana apical 1I-II Plasmodium vivax de Nicaragua (2012-2013): polimorfismo genético y antigénico

González-Cerón L, Piedra-Arévalo FO, Casanova-Hernández D, Santillán-Valenzuela F, Montoya-Pérez A

Idioma: Ingles.
Referencias bibliográficas: 51
Paginas: 127-135
Archivo PDF: 878.15 Kb.


RESUMEN

Objetivo. Se examinó el polimorfismo genético y antigénico del antígeno de membrana apical 1 (pvama1I-II) en P. vivax de Nicaragua. Material y métodos. Se obtuvieron muestras de sangre infectada de pacientes durante 2012-2013. Un fragmento génico de los dominios I-II se amplificó y secuenció. Se analizaron parámetros genéticos, relaciones haplotípicas, estructura genética y substitución de aminoácidos. Resultados. En 65 secuencias de pvama1I-II hubo 19 cambios no sinónimos y cinco sinónimos. Los parásitos nicaragüenses tuvieron baja diversidad y un alto desequilibrio de ligamiento. Las pruebas de neutralidad indicaron una selección positiva y divergente. Se evidenciaron tres grupos genéticos con pérdida de haplotipos. La variación de aminoácidos predominó en epítopos de células B, similar a parásitos de Latinoamérica. Conclusiones. P. vivax de Nicaragua fue moderadamente diferenciada en proceso de contracción y focalización, mientras que la diversidad antigénica fue similar a la reportada en parásitos de Latinoamérica. Esta información es relevante para el diseño de vacunas y la vigilancia epidemiológica.


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