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2021, Número 4

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Revista de Ciencias Médicas de la Habana 2021; 28 (4)


Genética, Genómica y COVID-19: implicaciones éticas

Quintana HD, Rojas BIA, Quintana MD, Fajardo PY, Oviedo CL
Texto completo Cómo citar este artículo Artículos similares

Idioma: Español
Referencias bibliográficas: 30
Paginas: 588-601
Archivo PDF: 1063.54 Kb.


PALABRAS CLAVE

genética, genómica, hospedero, COVID-19, ética.

RESUMEN

Introducción: La genética y la genómica contribuyen al desarrollo de enfoques personalizados y más efectivos para la prevención y el tratamiento de enfermedades infecciosas. Durante la actual pandemia se realizan estudios genómicos a pacientes con COVID-19 o expuestos no afectados, para delinear los factores del huésped asociados con la variabilidad en la susceptibilidad, la infectividad y gravedad de la enfermedad.
Objetivo: Describir las implicaciones éticas de la genética y genómica en la práctica clínica y la salud pública durante la pandemia de la COVID-19.
Métodos: Se consultan las bases bibliográficas de PubMed/Medline y Google académico. Se describen las implicaciones éticas, beneficios y perjuicios relacionados con los estudios genéticos y genómicos, en la práctica clínica y la salud pública en la COVID-19.
Conclusiones: Los estudios genéticos y genómicos desarrollados durante la pandemia de COVID-19 representan un logro de la coordinación y cooperación global.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Organización Mundial de la Salud. Coronavirus Disease (COVID-19) Dashboard. Data last updated: 2020/11/27 [Internet]. Ginebra: OMS; 2020 [citado 27 nov 2020]. Disponible en: https://covid19. who. int/

  2. Ministerio de Salud Pública de Cuba. Informe epidemiológico COVID-19, 27/11/2020. [citado 27 nov 2020]. Disponible en: https://salud. msp. gob. cu/

  3. Liu Y, Häussinger L, Steinacker JM, Dinse-Lambracht A. Association between the dynamics of the COVID-19 epidemic and ABO blood type distribution. Epidemiol Infect[Internet]. 2021 Jan 7[citado 13 Dic 2021];149:e19. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC7844181/

  4. American Association for the Advancement of Science[Internet]. Washington, DC: American Association for the Advancement of Science; © 2021. How sick will the coronavirus make you? The answer may be in your genes. [citado 13 Dic 2021]. Disponible en: https://www. science. org/content/article/how-sick-will-coronavirus-make-you-answer-may-be-your-genes

  5. Genetics Initiative. The COVID-19 Host Genetics Initiative, a global initiative to elucidate the role of host genetic factors in susceptibility and severity of the SARS-CoV-2 virus pandemic. Eur J Hum Genet[Internet]. 2020[citado 13 Dic 2021];28(6):715–8. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC7220587/

  6. Solomon I, Harrington E, Hooker G, Erby L, Axilbund J, Hampel H, et al. Lynch syndrome limbo: patient understanding of variants of uncertain significance. J Genet Couns[Internet]. 2017[citado 13 Dic 2021];26(4):866–77. Disponible en: https://onlinelibrary. wiley. com/doi/full/10. 1007/s10897-017-0066-y

  7. Brabbing Goldstein D, Reches A, Svirsky R, Bar Shira A, Yaron Y. Dilemmas in genetic counseling for low-penetrance neuro-susceptibility loci detected on prenatal chromosomal microarray analysis. Am J Obstet Gynecol[Internet]. 2018[citado 13 Dic 2021];218(2): 247. e1-247. e12. Disponible en: https://www. sciencedirect. com/science/article/abs/pii/S0002937817323244?via%3Dihub

  8. Brothers KB, Rothstein MA. Ethical, legal and social implications of incorporating personalized medicine into healthcare. Per Med[Internet]. 2015[citado 13 Dic 2021];12(1):43-51. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC4296905/

  9. Boyce AM, Garibaldi BT. Genomics and high-consequence infectious diseases: a scoping review of emerging science and potential ethical issues. Health Secur[Internet]. 2019 Jan/Feb[citado 13 Dic 2021];17(1):62-8. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC6424158/

  10. Walker A, Boyce A, Duggal P, Thio CL, Geller G. Genomics and infectious diseases: expert perspectives on public health considerations regarding actionability and privacy. Ethics Hum Res[Internet]. 2020 May[citado 13 Dic 2021];42(3):30-40. Disponible en: https://onlinelibrary. wiley. com/doi/epdf/10. 1002/eahr. 500051

  11. Kuo C-L, Pilling LC, Atkins JL, Masoli J, Delgado J, Kuchel GA, et al. APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort. J Gerontol A Biol Sci Med Sci[Internet]. 2020[citado 13 Dic 2021];75(11):2231–2. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC7314139/pdf/glaa131. pdf

  12. Sirugo G, Williams SM, Tishkoff SA. The missing diversity in human genetic studies. Cell[Internet]. 2019[citado 13 Dic 2021];177(1):26–31. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC7380073/

  13. Mills MC, Rahal C. The GWAS Diversity Monitor tracks diversity by disease in real time. Nat Genet[Internet]. 2020[citado 13 Dic 2021];52(3):242–3. Disponible en: https://www. ncbi. nlm. nih. gov/pubmed/32139905

  14. Milne R. Societal considerations in host genome testing for COVID-19. Genet Med[Internet]. 2020[citado 13 Dic 2021]; 22:1464–6. Disponible en: https://www. nature. com/articles/s41436-020-0861-y. pdf

  15. Greninger AL. Societal implications of the internet of pathogens. J Clin Microbiol[Internet]. 2019[citado 13 Dic 2021];57(6):e01914–e18. Disponible en: https://journals. asm. org/doi/epub/10. 1128/JCM. 01914-18

  16. Walker A, Boyce A, Geller G, Thio CL, Kahn JP. Direct-acting antivirals and hepatitis C: the ethics of price and rationing by genotype. Clin Infect Dis[Internet]. 2018[citado 13 Dic 2021];67(6):983–4. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC7190899/

  17. US Equal Employment Opportunity Commission[Internet]. Washington, DC: US Equal Employment Opportunity Commission; c2020. What you should know about COVID-19 and the ADA, the Rehabilitation Act, and other EEO laws. [citado 13 Dic 2021]. Disponible en: https://www. eeoc. gov/wysk/what-you-should-know-about-covid-19-and-ada-rehabilitation-act-and-other-eeo-laws

  18. Bentley AR, Callier SL, Rotimi CN. Evaluating the promise of inclusion of African ancestry populations in genomics. npj Genom Med[Internet]. 2020[citado 13 Dic 2021];5(5):1–9. Disponible en: https://www. nature. com/articles/s41525-019-0111-x. pdf

  19. Valdés Fernández BN, Duconge J, Espino AM, Ruaño G. Personalized health and the coronavirus vaccines-Do individual genetics matter? Bioessays[Internet]. 2021 Sep[citado 13 Dic 2021];43(9):e2100087. Disponible en: https://onlinelibrary. wiley. com/doi/epdf/10. 1002/bies. 202100087

  20. Molster CM, Bowman FL, Bilkey GA, Cho AS, Burns BL, Nowak KJ, Dawkins HJS. The Evolution of Public Health Genomics: Exploring Its Past, Present, and Future. Front Public Health[Internet]. 2018 Sep 4[citado 13 Dic 2021];6:247. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC6131666/

  21. Lantos JD. Ethical and Psychosocial Issues in Whole Genome Sequencing (WGS) for Newborns. Pediatrics[Internet]. 2019 Jan[citado 13 Dic 2021];143(Suppl 1):S1-S5. Disponible en: https://publications. aap. org/pediatrics/article/143/Supplement_1/S1/34201/Ethical-and-Psychosocial-Issues-in-Whole-Genome

  22. Mackley MP, Fletcher B, Parker M, Watkins H, Ormondroyd E. Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies. Genet Med[Internet]. 2017 Mar[citado 13 Dic 2021];19(3):283-93. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC5447864/pdf/gim2016109a. pdf

  23. Martinez-Martin N, Magnus D. Privacy and ethical challenges in next-generation sequencing. Expert Rev Precis Med Drug Dev[Internet]. 2019[citado 13 Dic 2021];4(2):95-104. https://www. ncbi. nlm. nih. gov/pmc/articles/PMC7413244/

  24. Kost RG, Poppel SM, Coller BS. Informed consent for next-generation nucleotide sequencing studies: Aiding communication between participants and investigators. J Clin Transl Sci[Internet]. 2017 Apr[citado 13 Dic 2021];1(2):115-120. Disponible en: https://www. cambridge. org/core/journals/journal-of-clinical-and-translational-science/article/informed-consent-for-nextgeneration-nucleotide-sequencing-studies-aiding-communication-between-participants-and-investigators/2B0293050882D3F0A240726367293B13

  25. Marchant G, Barnes M, Evans JP, LeRoy B, Wolf SM, Law Seq Liability Task Force. From genetics to genomics: facing the liability implications in clinical care. J Law Med Ethics[Internet]. 2020 Mar;48(1):11-43. Disponible en: https://journals. sagepub. com/doi/full/10. 1177/1073110520916994

  26. Coller BS. Ethics of human genome editing. Annu Rev Med[Internet]. 2019 Jan [citado 25 Abr 2021];70:289-305. Disponible en: https://doi:10. 1146/annurev-med-112717-094629

  27. Geller G, Duggal P, Thio CL, Mathews D, Kahn JP, Maragakis LL, et al. Genomics in the era of COVID-19: ethical implications for clinical practice and public health. Genome Med[Internet]. 2020 Nov[citado 25 Abr 2021];12(1):95. Disponible en: https://genomemedicine. biomedcentral. com/articles/10. 1186/s13073-020-00792-9

  28. Kumar S, Jha S, Rai SK. Significance of super spreader events in COVID-19. Indian J Public Health[Internet]. 2020 Jun[citado 25 Abr 2021]; 64(Suppl 2):S139-S141. Disponible en: https://www. ijph. in/temp/IndianJPublicHealth646139-6531668_180836. pdf

  29. Rotimi CN, Marshall PA. Tailoring the process of informed consent in genetic and genomic research. Genome Med[Internet]. 2010 [citado 25 Abr 2021];2:20. Disponible en: https://www. ncbi. nlm. nih. gov/pmc/articles/PMC2873798/

  30. Fariñas Acosta L. Cuba en busca del riesgo genético ante la COVID-19 [Internet]. Cubadebate. La Habana: UCI; © 2014 [actualizado 3 Nov 2020; citado 25 Abr 2021]. Disponible en: http://www. cubadebate. cu/especiales/2020/11/03/cuba-en-busca-del-riesgo-genetico-ante-la-covid-19/




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