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Federación Mexicana de Ginecología y Obstetricia, A.C.

2023, Número 07

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Ginecol Obstet Mex 2023; 91 (07)


Cambios en la microbiota durante el embarazo: revisión narrativa

Márquez IAA, Mariscal RBE, González PAM, Valbuena GE

Idioma: Español
Referencias bibliográficas: 137
Paginas: 499-515
Archivo PDF: 276.33 Kb.


RESUMEN

Objetivo: Evaluar la evidencia científica de los cambios en la microbiota durante el embarazo.
Metodología: Revisión de la bibliografía publicada entre el 2013 y el 2022 efectuada mediante la búsqueda de artículos científicos escritos en español e inglés resguardados en las bases de datos bibliográficas NICE, CENETEC-SALUD, BIREME y Portal OMS, OPS, Portal de Evidencias de la Biblioteca Virtual de Salud - BVS, LILACS, BIREME, EVIPNET, PubMed y Cochrane. La selección de artículos se basó en los descriptores: microbiota; embarazo-pregnancy; microbiota, gut microbiome, fetus-feto; microbiota, placenta; microbiota, combinadas entre sí con el operador boleano “and”.
Resultados: Se identificaron 3038 posibles artículos y 137 se encontraron adecuados para el objetivo de la revisión en virtud de estar relacionados directamente con el embarazo y la microbiota. Se revisaron estudios transversales, ensayos, revisiones, cohortes, casos y controles, revisiones sistemáticas o matanálisis.
Conclusiones: La microbiota se encuentra en diversos tejidos u órganos que anteriormente se creían estériles durante el embarazo. Se sugiere que todos los cambios que implica esta etapa pueden influir en la microbiota de la madre y el feto. A pesar de las crecientes investigaciones en el área aún quedan preguntas por contestar para ayudar a solucionar el enigma de los cambios en la diversidad en las diferentes complicaciones del embarazo y saber si los probióticos tendrían efecto o no en la disminución del riesgo a padecerlas.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Macpherson AJ, de Agüero MG, Ganal-Vonarburg SC. Hownutrition and the maternal microbiota shape the neonatalimmune system. Nat Rev Immunol 2017; 17 (8): 508-17.doi:10.1038/nri.2017.58

  2. Mesa M, Loureiro B, Iglesia I, Fernandez Gonzalez S, LlurbaOlivé E, García Algar O et al. The Evolving Microbiome fromPregnancy to Early Infancy: A Comprehensive Review. Nutrients2020; 12 (1): 133.doi:10.3390/nu12010133

  3. Coscia A, Bardanzellu F, Caboni E, Fanos V, Peroni D. Whena Neonate Is Born, So Is a Microbiota. Life: (Basel) 2021;11: (2): 148. doi:10.3390/life11020148

  4. Ganal S, Fuhrer T, Gomez M. Maternal microbiota andantibodies as advocates of neonatal health. Gut Microbes.2017; 8: (5): 479-85. doi:10.1080/19490976.2017.1299847

  5. Solt I. The human microbiome and the great obstetricalsyndromes: a new frontier in maternal-fetal medicine.Best Pract Res Clin Obstet Gynaecol 2015; 29 (2): 165-75.doi:10.1016/j.bpobgyn.2014.04.024

  6. Macpherson A, de Agüero M, Ganal-Vonarburg S. Hownutrition and the maternal microbiota shape the neonatalimmune system. Nat Rev Immunol 2017; 17: (8): 508-17.doi:10.1038/nri.2017.58

  7. Al Z, Eberl G. Imprinting of the immune system by the microbiotaearly in life. Mucosal Immunol 2020; 13: 183-89https: //doi.org/10.1038/s41385-020-0257-y

  8. Younge N, McCann J, Ballard J, Plunkett C, Akhtar S, AraújoF, Murtha A, Brandon D, Seed P. Fetal exposure to the maternalmicrobiota in humans and mice. JCI Insight 2019; 4(19): e127806. doi:10.1172/jci.insight.127806

  9. Ratsika A, Codagnone MC, O’Mahony S, Stanton C, CryanJF. Priming for Life: Early Life Nutrition and the Microbiota-Gut-Brain Axis. Nutrients 2021; 13: 423. https: //doi.org/

  10. 10.3390/nu1302042310. Kozyrskyj AL, Kalu R, Koleva PT, Bridgman SL. Fetal programmingof overweight through the microbiome: boys aredisproportionately affected. J Dev Orig Health Dis 2016; 7(1): 25-34. doi:10.1017/S2040174415001269

  11. Galley JD, Bailey M, Kamp Dush C, Schoppe-Sullivan S,Christian LM. Maternal obesity is associated with alterationsin the gut microbiome in toddlers. PLoS One 2014; 9(11): e113026. doi:10.1371/journal.pone.0113026

  12. Soderborg TK, Carpenter CM, Janssen RC, Weir TL, RobertsonCE, et al. Gestational diabetes is uniquely associatedwith altered early seeding of the infant gut microbiota.Front. Endocrinol 2020; 11: 603021. doi:10.3389/fendo.2020.603021

  13. Kozyrskyj AL, Kalu R, Koleva PT, Bridgman SL. Fetal programmingof overweight through the microbiome: boys aredisproportionately affected. J Dev Orig Health Dis 2016; 7(1): 25-34. doi:10.1017/S2040174415001269

  14. Kozyrskyj AL, Sloboda DM. Perinatal programming of gutmicrobiota and immunity. J Dev Orig Health Dis 2016; 7(1): 2-4. doi:10.1017/s2040174415007916

  15. Butel MJ, Waligora-Dupriet AJ, Wydau-Dematteis S. Thedeveloping gut microbiota and its consequences for health.J Dev Orig Health Dis 2018; 9 (6): 590-97. doi:10.1017/S2040174418000119

  16. Abrahamsson TR, Wu RY, Jenmalm MC. Gut microbiota andallergy: the importance of the pregnancy period. PediatrRes 2015; 77 (1-2): 214-19. doi:10.1038/pr.2014.165

  17. Bolte EE, Moorshead D, Aagaard KM. Maternal and earlylife exposures and their potential to influence developmentof the microbiome. Genome Med 2022; 14 (1): 4.doi:10.1186/s13073-021-01005-7

  18. Mandal S, Godfrey KM, McDonald D, et al. Fat and vitaminintakes during pregnancy have stronger relations with apro-inflammatory maternal microbiota than does carbohydrateintake. Microbiome 2016 ; 4 (1): 55. doi:10.1186/s40168-016-0200-3

  19. Chu DM, Antony KM, Ma J, et al. The early infant gut microbiomevaries in association with a maternal high-fat diet. GenomeMed 2016; 8 (1): 77. doi:10.1186/s13073-016-0330-z

  20. Kuperman AA, Koren O. Antibiotic use during pregnancy:how bad is it? BMC Med. 2016; 14 (1): 91. doi:10.1186/s12916-016-0636-0

  21. Neu J. Developmental aspects of maternal-fetal, and infantgut microbiota and implications for long-term health.Matern Health Neonatol Perinatol 2015; 1: 6. doi:10.1186/s40748-015-0007-4

  22. Bolte EE, Moorshead D, Aagaard KM. Maternal and earlylife exposures, and their potential to influence developmentof the microbiome. Genome Med 2022; 14 (1): 4.doi:10.1186/s13073-021-01005-7

  23. Romero Herrero D, Andreu Domingo A. Vaginosis bacteriana.Enfermedades Infecciosas y Microbiología Clínica 2016;34: 14-18. doi:10.1016/s0213-005x (16)30214-2

  24. Hasain Z, Mokhtar NM, Kamaruddin NA, MohamedIsmail NA, Razalli NH, Gnanou JV, et al. Gut microbiotaand gestational diabetes mellitus: a review of host-gutmicrobiota interactions and their therapeutic potential.Front Cell Infect Microbiol 2020; 10: 188. doi:10.3389/fcimb.2020.00188

  25. Fox C, Eichelberger K. Maternal microbiome and pregnancyoutcomes. Fertil Steril 2015; 104 (6): 1358-63.doi:10.1016/j.fertnstert.2015.09.037

  26. Wang J, Gu X, Yang J, Wei Y, Zhao Y. Gut microbiota dysbiosisand increased plasma LPS and TMAO levels in patients withpreeclampsia. Front Cell Infect Microbiol 2019; 9: 409.doi:10.3389/fcimb.2019.00409

  27. Ansari A, Bose S, You Y, Park S, Kim Y. Molecular Mechanismof Microbiota Metabolites in Preterm Birth: Pathologicaland Therapeutic Insights. Int J Mol Sci. 2021; 22 (15): 8145.doi:10.3390/ijms22158145

  28. Mora-Janiszewska O, Faryniak-Zuzak A, Darmochwał-KolarzD. Epigenetic Links between Microbiota and GestationalDiabetes. Int J Mol Sci. 2022; 23 (3): 1831. doi:10.3390/ijms23031831

  29. Fernandez-Gonzalez S, Ortiz-Arrabal O, Torrecillas A,Pérez-Cruz M, Chueca N, Gómez-Roig MD, et al. Studyof the fetal and maternal microbiota in pregnant womenwith intrauterine growth restriction and its relationshipwith inflammatory biomarkers. Medicine. 2020; 99 (46):e22722. doi:10.1097/MD.0000000000022722

  30. Dunlop AL, Mulle JG, Ferranti EP, Edwards S, Dunn AB,Corwin EJ. Maternal Microbiome and Pregnancy OutcomesThat Impact Infant Health. Adv Neonatal Care. 2015; 15 (6):377–85. doi:10.1097/ANC.0000000000000218

  31. Alsharairi NA. The Infant Gut Microbiota and Risk of Asthma:The Effect of Maternal Nutrition during Pregnancy andLactation. Microorganisms. 2020; 8 (8): 1119. doi:10.3390/microorganisms8081119

  32. Li X, Yu D, Wang Y, Yuan H, Ning X, Rui B, et al. The IntestinalDysbiosis of Mothers with Gestational Diabetes Mellitus:(GDM) and Its Impact on the Gut Microbiota of TheirNewborns. Chen T, editor. Can J Infect Dis Med Microbiol2021; 2021: 1–12. doi:10.1155/2021/3044534

  33. Neri C, Serafino E, Morlando M, Familiari A. Microbiomeand Gestational Diabetes: Interactions with PregnancyOutcome and Long-Term Infant Health. Goebl CS, editor. JDiabetes Res 2021; 2021: 1–10. doi:10.1155/2021/9994734

  34. Ahmadian E, Rahbar Saadat Y, Hosseiniyan Khatibi SM, Nariman-Saleh-Fam Z, Bastami M, Zununi Vahed F, et al. Pre-Eclampsia: Microbiota possibly playing a role. PharmacolRes 2020; 155: 104692. doi:10.1016/j.phrs.2020.104692.

  35. Prince AL, Ma J, Kannan PS, Alvarez M, Gisslen T, HarrisRA, et al. The placental membrane microbiome is alteredamong subjects with spontaneous preterm birth with andwithout chorioamnionitis. Am J Obstet Gynecol 2016; 214(5): 627.e1-627.e16. doi:10.1016/j.ajog.2016.01.193

  36. Vinturache AE, Gyamfi-Bannerman C, Hwang J, MysorekarIU, Jacobsson B. Maternal microbiome. A pathway to pretermbirth. Semin Fetal Neonatal Med 2016; 21 (2): 94–9.doi:10.1016/j.siny.2016.02.004

  37. Wang J, Zheng J, Shi W, Du N, Xu X, Zhang Y, et al. Dysbiosisof maternal and neonatal microbiota associated withgestational diabetes mellitus. Gut 2018; 67 (9): 1614-25.doi:10.1136/gutjnl-2018-315988

  38. Chernikova DA, Koestler DC, Hoen AG, Housman ML,Hibberd PL, Moore JH, et al. Fetal exposures and perinatalinfluences on the stool microbiota of premature infants. JMatern Neonatal Med 2016; 29 (1): 99-105. doi:10.3109/14767058.2014.987748

  39. Ponzo V, Fedele D, Goitre I, Leone F, Lezo A et al Diet-GutMicrobiota Interactions and Gestational Diabetes Mellitus:(GDM). Nutrients 2019; 11: 330. doi:10.3390/nu11020330

  40. Yang H Guo R, Li S, et al. Systematic analysis of gut microbiotain pregnant women and its correlations with individualheterogeneity. NPJ Biofilms Microbiomes 2020; 6 (1): 32).doi:10.1038/s41522-020-00142-y

  41. Di Simone, Nicoletta, et al. Recent insights on the maternalmicrobiota: impact on pregnancy outcomes.Frontiers in Immunology 2020; 11: 528202. doi:10.3389/fimmu.2020.528202

  42. Zacarõ AS, Collado MC, Go mez-Gallego C, Flinck H, AittoniemiJ, Isolauri E, et al. Pregestational overweight andobesity are associated with differences in gut microbiotacomposition and systemic inflammation in the third trimester.PLoS ONE 2018; 13 (7): e0200305. doi:10.1371/journal.pone.0200305

  43. Sakurai K, Kato T, Tanabe H, Taguchi-Atarashi N, Sato Y,Eguchi A, Watanabe M, Ohno H, Mori C. Association betweengut microbiota composition and glycoalbumin levelduring pregnancy in Japanese women: Pilot study fromChiba Study of Mother and Child Health. J Diabetes Investig2020; 11 (3): 699-706. doi:10.1111/jdi.13177

  44. Kapourchali, Fatemeh Ramezani, and Gail AM Cresci.Early‐Life Gut Microbiome. The Importance of Maternaland Infant Factors in Its Establishment. Nutrition in ClinicalPractice. 2020; 35 (3), 386-405. doi:10.1002/ncp.10490

  45. Robinson A, Fiechtner L, Roche B, Ajami N, PetrosinoJ, Camargo C et al. Association of maternal gestationalweight gain with the infant fecal microbiota. J PediatrGastroenterol Nutr 2017; 65 (5): 509-515. doi:10.1097/MPG.0000000000001566

  46. Abrahamsson, Thomas R., Richard You Wu, Jenmalm MC.Gut microbiota and allergy: the importance of the pregnancyperiod. Pediatric Research 2015; 77: (1): 214-19.doi:10.1038/pr.2014.165

  47. Walker R, Clemente J, Peter I, Loos R. The prenatal gutmicrobiome: are we colonized with bacteriain utero?Pediatric Obesity 2017; 12: 3-17. doi:10.1111/ijpo.12217

  48. Hu J, Nomura Y, Bashir A, Fernandez-Hernandez H, ItzkowitzS, et al. Diversified microbiota of meconium is affected bymaternal diabetes status. PLoS ONE 2013; 8 (11): e78257.doi:10.1371/journal.pone.0078257

  49. Grech A, Collins C, Holmes A, Lal R, Duncanson K, TaylorR, Gordon A. Maternal exposures and the infant gutmicrobiome: a systematic review with meta-analysis.Gut Microbes 2021; 13: (1): 1-30. doi:10.1080/19490976.2021.1897210

  50. Singh A, Mahima M. Neonatal microbiome–a brief review.J Maternal-Fetal & Neonatal Medicine 2020; 33 (22): 3841-48. doi:10.1080/14767058.2019.1583738

  51. Yao Y, Cai X, Ye Y, Wang F, Chen F, Zheng C. The Roleof Microbiota in Infant Health: From Early Life toAdulthood. Front. Immunol 2021; 12: 708472. doi:10.3389/fimmu.2021.708472

  52. Miko E, Csaszar A, Bodis J, Kovacs K. The Maternal-Fetal GutMicrobiota Axis: physiological changes, dietary influence,and modulation possibilities. Life (Basel) 2022; 12: (3): 424.doi:10.3390/life12030424

  53. Nuriel-Ohayon M, Neuman Hand Koren O. Microbial Changesduring Pregnancy, Birth, and Infancy. Front Microbiol2016; 7: 1031. https: //doi.org/10.3389/fmicb.2016.01031

  54. Edwards S, Cunningham S, Dunlop A, Corwin E. Thematernal gut microbiome during pregnancy. MCN Am JMatern Child Nurs 2017; 42: (6): 310-17. doi:10.1097/NMC.0000000000000372

  55. Siena M, Laterza L, Matteo M, Mignini I, Schepis T, et al.Gut and reproductive tract microbiota adaptation duringpregnancy: new insights for pregnancy-related complicationsand therapy. Microorganisms 2021; 9: (3): 473.doi:10.3390/microorganisms9030473

  56. Chung, Seon-Yoon, Ravel J, Regan M. Clinical relevance ofgastrointestinal microbiota during pregnancy: A primerfor nurses. Biological Research for Nursing 2018; 20: (1):84-102. doi: 10.1177/1099800417732412

  57. Buffington, Shelly A., et al. Microbial reconstitution reversesmaternal diet-induced social and synaptic deficits inoffspring. Cell. 2016; 165: (7): 1762-1775. doi:10.1016/j.cell.2016.06.001

  58. Chu D, Valentine G, Seferovic M, Aagaard K. The Developmentof the Human Microbiome. Gastroenterology Clinicsof North America. 2019; 48 (3): 357-375. doi:10.1016/j.gtc.2019.04.004

  59. Gohir W, Whelan F, Surette M, Moore C, Schertzer J, SlobodaD. Pregnancy-related changes in the maternal gutmicrobiota are dependent upon the mother's periconceptionaldiet. Gut Microbes. 2015; 6: (5): 310-20. doi:10.1080/19490976.2015.1086056.

  60. You Y-A, Yoo JY, Kwon EJ and Kim YJ. Blood MicrobialCommunities During Pregnancy Are Associated With PretermBirth. Front. Microbiol 2019; 10: 1122. doi:10.3389/fmicb.2019.01122

  61. Valentine, Gregory, et al. Relationships between perinatalinterventions, maternal-infant microbiomes, and neonataloutcomes. Clinics in Perinatology. 2018; 45 (2): 339-355.doi:10.1016/j.clp.2018.01.008

  62. Underwood, Mark A., et al. Disbiosis intestinal neonatal.Journal of Perinatology. 2020; 40 (11): 1597-1608. doi.org/10.1038/s41372-020-00829-2

  63. Rautava, Samuli. Microbial composition of the initialcolonisation of newborns. Gut microbiome: functionalaspects in health and disease.: 2017; 88: 11-22.doi:10.1159/000455209

  64. Drell, Tiina, et al.: The influence of different maternalmicrobial communities on the development of infant gutand oral microbiota. Scientific reports. 2017; 7 (1): 1-9.doi:10.1038/s41598-017-09278-y

  65. Hill, Cian J., et al. Evolution of gut microbiota compositionfrom birth to 24 weeks in the INFANTMET cohort. Microbiome.2017; 5 (1): 1-18. doi 10.1186/s40168-016-0213-y

  66. Zhang Z, Xue C, Ju M, Guo J, Wang M, Yi S, Yi X. Maternal gutdysbiosis alters offspring microbiota and social interactions.Microorganisms. 2021 Aug 15; 9 (8): 1742. doi:10.3390/microorganisms9081742

  67. Su M, Nie Y, Shao R, Duan S, Jiang Y, Wang M, et al. Diversifiedgut microbiota in newborns of mothers withgestational diabetes mellitus. PLoS ONE. 2018; 13 (10):e0205695. https: //doi.org/10.1371/journal.pone.0205695

  68. Chen, Ting y otros. Gestational diabetes mellitus is associatedwith neonatal gut microbiota and metabolome.BMC Medicine. 2021; 19 (1): 1-10. doi:10.1186/s12916-021-01991-w

  69. Crusell, Mie Korslund Wiinblad, et al. Gestational diabetesis associated with changes in gut microbiota compositionin the third trimester of pregnancy and postpartum. Microbiome2018; 6 (1): 1-19. doi : 10.1186/s40168-018-0472-x

  70. Mirpuri, Julie y Josef Neu. Maternal microbial factors affectingthe foetus and subsequent offspring. Seminars in Perinatology.2021; 45: 6. doi :10.1016/j.semperi.2021.151449

  71. Vuillermin, Peter J., et al. "The maternal microbiomeduring pregnancy and allergic disease in the offspring."Seminars in immunopathology.2017; 39: 6. doi 10.1007/s00281-017-0652-y

  72. Gao, Yuan, et al. The maternal gut microbiome duringpregnancy and offspring allergy and asthma. Journal ofAllergy and Clinical Immunology. 2021; 148 (3): 669-678.doi:10.1016/j.jaci.2021.07.011

  73. Nyangahu DD, Jaspan HB. Influence of maternal microbiotaduring pregnancy on infant immunity. Clin Exp Immunol2019; 198 (1): 47–56. doi:10.1111/cei.13331

  74. Sohn K, Underwood MA. Prenatal and postnatal administrationof prebiotics and probiotics. Semin Fetal NeonatalMed. 2017; 22 (5): 284–9. doi:10.1016/j.siny.2017.07.002.

  75. Castanys-Muñoz E, Martin MJ, Vazquez E. Building a BeneficialMicrobiome from Birth. Adv Nutr. 2016; 7 (2): 323–30.doi:10.3945/an.115.010694

  76. Forsgren M, Isolauri E, Salminen S, Rautava S. Late pretermbirth has direct and indirect effects on infant gut microbiotadevelopment during the first six months of life. ActaPaediatr. 2017; 106 (7): 1103–9. doi:10.1111/apa.13837.

  77. Grewal K, MacIntyre DA, Bennett PR. The reproductivetract microbiota in pregnancy. Biosci Rep. 2021; 41 (9):BSR20203908. doi:10.1042/BSR20203908

  78. Senn V, Bassler D, Choudhury R, Scholkmann F, Righini-Grunder F, Vuille-dit-Bille recién nacido, et al. MicrobialColonization From the Fetus to Early Childhood—A ComprehensiveReview. Front Cell Infect Microbiol 2020; 10:573735. doi:10.3389/fcimb.2020.573735

  79. Moriana L, Mach N. Influencia de la gestación, el parto yel tipo de lactancia sobre la microbiota intestinal del neonato.Acta Pediatr Esp.2014; 72 (2): 37-44. https: //www.actapediatrica.com/images/pdf/Volumen-72---Numero-2---Febrero-2014.pdf

  80. Sakwinska O, Foata F, Berger B, Brüssow H, Combremont S,Mercenier A, et al. Does the maternal vaginal microbiotaplay a role in seeding the microbiota of neonatal gut andnose? Benef Microbes. 2017; 8 (5): 763–78. doi:10.3920/BM2017.0064

  81. Nunez N, Réot L, Menu E. Neonatal Immune System Ontogeny:The Role of Maternal Microbiota and AssociatedFactors. How Might the Non-Human Primate Model Enlightenthe Path? Vaccines. 2021; 9 (6): 584. doi:10.3390/vaccines9060584

  82. Wolfarth AA, Smith TM, VanInsberghe D, Dunlop AL, NeishAS, Corwin EJ, et al. A Human Microbiota-AssociatedMurine Model for Assessing the Impact of the VaginalMicrobiota on Pregnancy Outcomes. Front Cell Infect Microbiol2020; 10: 570025. doi:10.3389/fcimb.2020.570025

  83. Agostinis C, Mangogna A, Bossi F, Ricci G, Kishore U,Bulla R. Uterine Immunity and Microbiota: A ShiftingParadigm. Front Immunol 2019; 10: 2387. doi:10.3389/fimmu.2019.02387.

  84. Kim G, Bae J, Kim MJ, Kwon H, Park G, Kim S-J, et al. DelayedEstablishment of Gut Microbiota in Infants Deliveredby Cesarean Section. Front Microbiol . 2020; 11: 2099.doi:10.3389/fmicb.2020.02099

  85. Coelho GDP, Ayres LFA, Barreto DS, Henriques BD, PradoMRMC, Passos CM Dos. Acquisition of microbiota accordingto the type of birth: an integrative review. Rev LatAm Enfermagem. 2021; 29: e3446. doi:10.1590/1518.8345.4466.3446.

  86. Korpela K. Impact of Delivery Mode on Infant Gut Microbiota.Ann Nutr Metab. 2021; 77 (Suppl. 3): 11–9.doi:10.1159/000518498

  87. Hoang DM, Levy EI, Vandenplas Y. The impact of Caesareansection on the infant gut microbiome. Acta Paediatr. 2021;110 (1): 60–7. doi:10.1111/apa.15501.

  88. Raspini B, Vacca M, Porri D, De Giuseppe R, CalabreseFM, Chieppa M, et al. Early Life Microbiota Colonizationat Six Months of Age: A Transitional Time Point. FrontCell Infect Microbiol 2021; 11: 590202. doi:10.3389/fcimb.2021.590202

  89. Reyman M, van Houten MA, van Baarle D, Bosch AATM,Man WH, Chu MLJN, et al. Impact of delivery modeassociatedgut microbiota dynamics on health in the firstyear of life. Nat Commun. 2019 ; 10 (1): 4997. doi:10.1038/s41467-019-13014-7.

  90. Qureshi F, Edhi F, Ozga A. The Impact of Delivery Mode onthe Human Microbiome: A Global Perspective. Mako NSUUndergrad Student J. 2022; 1. https: //nsuworks.nova.edu/cgi/viewcontent.cgi?article=1033&context=mako/

  91. Parnell L, Briggs C, Mysorekar I. Maternal microbiomesin preterm birth: Recent progress and analytical pipelines.Seminars in Perinatology. 2017; 41 (7): 392-400.doi:10.1053/j.semperi.2017.07.010

  92. Chen H, Gur T. Intrauterine Microbiota: Missing, or theMissing Link? Trends in Neurosciences. 2019; 42 (6): 402-413. doi:10.1016/j.tins.2019.03.008

  93. Beckers, Kalie F., and Jenny L. Sones. Maternal microbiomeand the hypertensive disorder of pregnancy, preeclampsia.American Journal of Physiology-Heart and CirculatoryPhysiology. 2020; 318: (1): H1-H10. doi:10.1152/ajpheart.00469.2019

  94. Dudley, D. J. The placental microbiome: yea, nay or maybe?.BJOG: an international journal of obstetrics and gynaecology.2020; 127: (2): 170. Doi: 10.1111/1471-0528.15896

  95. Aagaard K, Ma J, Antony K, Ganu R, Petrosino J, VersalovicJ. The placenta harbors a unique microbiome. Sci TranslMed 2014; 6: (237): 237ra65. doi:10.1126/scitranslmed.3008599.

  96. Zakis D, Paulissen E, Kornete L, Kaan A, Nicu E, Zaura E.The evidence for placental microbiome and its compositionin healthy pregnancies: A systematic review. Journalof Reproductive Immunology 2022; 149: 103455. doi.org/10.1016/j.jri.2021.103455

  97. Pelzer E, Gomez-Arango LF, Barrett HL, Nitert MD. Review:Maternal health and the placental microbiome. Placenta2017; 54: 30-37. doi:10.1016/j.placenta.2016.12.003

  98. Farooqi H, Kim K, Kausar F, Muhammad J, Bukhari H,Choi K. Frequency and Molecular Characterization of Staphylococcusaureus from Placenta of Mothers with Termand Preterm Deliveries. Life: (Basel) 2022; 12: (2): 257.doi:10.3390/life12020257

  99. Yao Y, Cai X, Chen C, Fang H, Zhao Y, Fei W, Chen F, ZhengC. The Role of Microbiomes in Pregnant Women and Offspring:Research Progress of Recent Years. Front Pharmacol2020; 11: 643. doi:10.3389/fphar.2020.00643.

  100. Tang N, Luo Z-C, Zhang L, Zheng T, Fan P, Tao Y and Ouyang F.The Association Between Gestational Diabetes and Microbiotain Placenta and Cord Blood. Front Endocrinol 2020;11: 550319. doi:10.3389/fendo.2020.550319

  101. Antony K, Ma J, Mitchell K, Racusin D, Versalovic J, AagaardK. The preterm placental microbiome varies in associationwith excess maternal gestational weight gain. Am JObstet Gynecol 2015; 212: (5): 653.e1-16. doi:10.1016/j.ajog.2014.12.041

  102. Bassols J, Serino M, Carreras-Badosa G, Burcelin R, Blasco-Baque V, Lopez-Bermejo A, Fernandez-Real JM. Gestationaldiabetes is associated with changes in placental microbiotaand microbiome. Pediatr Res 2016; 80 (6): 777-784.doi:10.1038/pr.2016.155

  103. Zheng J, Xiao X, Zhang Q, Mao L, Yu M, Xu J. The PlacentalMicrobiome Varies in Association with Low Birth Weightin Full-Term Neonates. Nutrients 2015; 7 (8): 6924-37.doi:10.3390/nu7085315

  104. Vander Haar EL, Wu G, Gyamfi-Bannerman C, et al. Microbialanalysis of umbilical cord blood reveals novel pathogensassociated with stillbirth and early preterm birth.mBio 2022; 13 (5): e0203622. doi:10.1128/mbio.02036-22

  105. Rio-Aige K, Azagra-Boronat I, Massot-Cladera M, Selma-RoyoM, Parra-Llorca A, et al. Association of maternal microbiotaand diet in cord blood cytokine and immunoglobulin profiles.Int J Mol Sci 2021; 22 (4): 1778. doi:10.3390/ijms22041778

  106. Jang, Hoonji, et al. Oral microflora and pregnancy: a systematicreview and meta-analysis. Scientific reports 2021; 11(1): 1-31. doi:10.1038/s41598-021-96495-1

  107. He Z, Wu J, Xiao B, Xiao S, Li H, Wu K. The initial oral microbiotaof neonates among subjects with gestational diabetesmellitus. Frontiers in Pediatrics 2019; 7: 513. doi:10.3389/fped.2019.00513

  108. Dunlop A, Knight A, Satten G, Cutler A, Wright M, MitchellR et al. Stability of the vaginal, oral, and gut microbiotaacross pregnancy among African American women: theeffect of socioeconomic status and antibiotic exposure.PeerJ 2019; 7: e8004. doi:10.7717/peerj.8004

  109. Urushiyama D, Suda W, Ohnishi E, Araki R, Kiyoshima C, KurakazuM, et al. Microbiome profile of the amniotic fluid as apredictive biomarker of perinatal outcome. Scientific Reports2017; 22: 7. https: //doi.org/10.1038/s41598-017-11699-8

  110. Neu J. The microbiome during pregnancy and early postnatallife. Seminars in Fetal and Neonatal Medicine 2016;21 (6): 373-9. doi:10.1016/j.siny.2016.05.001

  111. Winters AD, Romero R, Greenberg JM, et al. Does theAmniotic Fluid of Mice Contain a Viable Microbiota?Front Immunol 2022; 13: 820366. https: //doi:10.3389/fimmu.2022.820366

  112. Mei C, Yang W, Wei X, Wu K and Huang D. The UniqueMicrobiome and Innate Immunity During Pregnancy. Front.Immunol 2019; 10: 2886. doi:10.3389/fimmu.2019.02886

  113. Kumar M, Murugesan S, Singh P, Saadaoui M, Elhag DA,Terranegra A, Kabeer BSA, Marr AK, Kino T, BrummaierT, McGready R, Nosten F, Chaussabel D and Al Khodor S.Vaginal Microbiota and Cytokine Levels Predict PretermDelivery in Asian Women. Front. Cell. Infect. Microbiol2021; 11: 639665. doi:10.3389/fcimb.2021.639665

  114. Gupta P, Singh M, Goyal K. Diversity of Vaginal Microbiomein Pregnancy: Deciphering the Obscurity. Front PublicHealth. 2020; 8: 326. doi:10.3389/fpubh.2020.00326.

  115. Heil, Babiche A, Dale L, Paccamonti, Jenny L. Sones. Rolefor the mammalian female reproductive tract microbiomein pregnancy outcomes. Physiological Genomics 2019; 51(8): 390-399. doi:10.1152/physiolgenomics.00045.201

  116. Al-Nasiry S, Ambrosino E, Schlaepfer M, Morré SA, WietenL, Voncken JW, Spinelli M, Mueller M and Kramer BW. TheInterplay Between Reproductive Tract Microbiota andImmunological System in Human Reproduction. Front.Immunol 2020; 11: 378. doi:10.3389/fimmu.2020.00378

  117. Heil BA, Paccamonti DL, Sones JL. Role for the mammalianfemale reproductive tract microbiome in pregnancy outcomes.Physiol Genomics. 2019; 51 (8): 390-399. doi:10.1152/physiolgenomics.00045.2019

  118. Baker JM, Chase DM and Herbst-Kralovetz MM. Uterine Microbiota:Residents, Tourists, or Invaders? Front. Immunol2018; 9: 208. doi:10.3389/fimmu.2018.00208

  119. Swanson KS, Gibson GR, Hutkins R, Reimer RA, Reid G, VerbekeK, et al. The International Scientific Association for Probioticsand Prebiotics: (ISAPP) consensus statement on the definitionand scope of synbiotics. Nat Rev Gastroenterol Hepatol 2020;17 (11): 687–701. doi:10.1038/s41575-020-0344-2.

  120. Gille C, Böer B, Marschal M, Urschitz MS, Heinecke V, HundV, et al. Effect of probiotics on vaginal health in pregnancy.EFFPRO, a randomized controlled trial. Am J ObstetGynecol 2016; 215 (5): 608.e1-608.e7. doi:10.1016/j.ajog.2016.06.021

  121. Chen Y, Li Z, Tye KD, Luo H, Tang X, Liao Y, et al. Probioticsupplementation during human pregnancy affects the gutmicrobiota and immune status. Front Cell Infect Microbiol2019; 9. doi:10.3389/fcimb.2019.0025

  122. Rutten N, Van der Gugten A, Uiterwaal C, Vlieger A, RijkersG, et al. Maternal use of probiotics during pregnancy andeffects on their offspring’s health in an unselected population.Eur J Pediatr 2016; 175 (2): 229-35. doi:10.1007/s00431-015-2618-1

  123. Davidson SJ, Barrett HL, Price SA, Callaway LK, Dekke,et l. Probiotics for preventing gestational diabetes. CochraneDatabase Syst Rev 2021; 19: 4 (4): CD009951.doi:10.1002/14651858.CD009951.pub3

  124. Baldassarre M, Palladino V, Amoruso A, Pindinelli S, MastromarinoP, et al. Rationale of probiotic supplementationduring pregnancy and neonatal period. Nutrients 2018; 10(11): 1693. doi:10.3390/nu10111693

  125. Martín-Peláez S, Cano-Ibáñez N, Pinto-Gallardo M,Amezcua-Prieto C. The impact of probiotics, prebiotics, andsynbiotics during pregnancy or lactation on the intestinalmicrobiota of children born by cesarean section: A systematicreview. Nutrients 2022; 14 (2): 341. doi:10.3390/nu14020341

  126. Pronovost G, Hsiao E. Perinatal Interactions between theMicrobiome, Immunity, and Neurodevelopment. Immunity.2019; 50 (1): 18-36. doi:10.1016/j.immuni.2018.11.016

  127. Zietek M, Celewicz Z, Szczuko M. Short-Chain fatty acids,maternal microbiota and metabolism in pregnancy.Nutrients 2021; 13: 1244. doi.org/10.3390/nu13041244

  128. Zhou L, Xiao X. The role of gut microbiota in the effects ofmaternal obesity during pregnancy on offspring metabolism.Biosci Rep. 2018; 38 (2): BSR20171234. doi:10.1042/BSR20171234

  129. Cortés-Macías, E.; Selma-Royo, M.; Martínez-Costa, C.;Collado, M.C. Breastfeeding Practices Influence the BreastMilk Microbiota Depending on Pre-Gestational MaternalBMI andWeight Gain over Pregnancy. Nutrients .2021; 13:1518. doi.org/10.3390/nu13051518

  130. Mulligan C, Friedman J. Maternal modifiers of the infantgut microbiota: metabolic consequences. Journal of Endocrinology.2017; 235 (1): R1-R12. doi:10.1530/JOE-17-0303

  131. Mjaaseth UN, Norris JC, Aardema NDJ, Bunnell ML, et al.Excess vitamins or imbalance of folic acid and choline in thegestational diet alter the gut microbiota and obesogeniceffects in wistar rat offspring. Nutrients 2021; 13: 4510.doi:10.3390/nu13124510

  132. Gao Y, Nanan R, Macia L, et al. The maternal gut microbiomeduring pregnancy and offspring allergy and asthma. JAllergy Clin Immunol 2021; 148 (3): 669-678. doi:10.1016/j.jaci.2021.07.011

  133. Wang, Y.; Xie, T.; Wu, Y.; Liu, Y.; Zou, Z.; Bai, J. Impacts ofMaternal Diet and Alcohol Consumption during Pregnancyon Maternal and Infant Gut Microbiota. Biomolecules.2021; 11: 369. doi:10.3390/biom11030369

  134. Bhagavata S, Raipuria M, Bahari H, Kaakoush NO, etal.Impacts of diet and exercise on maternal gut microbiotaare transferred to offspring. Front Endocrinol 2018; 9: 716.doi:10.3389/fendo.2018.00716

  135. Astbury S, Song A, Zhou M, Nielsen B, Hoedl A, et al.High fructose intake during pregnancy in rats influencesthe maternal microbiome and gut development inthe offspring. Front. Genet. 2018; 9: 203. doi:10.3389/fgene.2018.00203

  136. García I, Selma M, González S, Parra A, Martínez C, ColladoM. Distinct maternal microbiota clusters are associatedwith diet during pregnancy: impact on neonatal microbiotaand infant growth during the first 18 months of life. GutMicrobes 2020; 11: (4): 962-978. doi:10.1080/19490976.2020.1730294.

  137. Chen C-M, Chou H-C and Yang Y-CSH. Maternal antibiotictreatment disrupts the intestinal microbiota and intestinaldevelopment in neonatal mice. Front. Microbiol 2021; 12:684233. doi:10.3389/fmicb.2021.684233




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