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Federación Mexicana de Ginecología y Obstetricia, A.C.

2023, Número 08

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Ginecol Obstet Mex 2023; 91 (08)


Evaluación del polimorfismo Pro12Ala del gen PPARg en mujeres con diabetes mellitus gestacional

Rodríguez CD, Mejía II, Márquez AYA, Vargas HMA, Sánchez MV

Idioma: Español
Referencias bibliográficas: 24
Paginas: 581-587
Archivo PDF: 244.20 Kb.


RESUMEN

Objetivo: Determinar la frecuencia del alelo Ala en una muestra de mujeres mexicanas con diabetes mellitus gestacional y asociar su repercusión en la glucemia.
Materiales y Métodos: Estudio ambispectivo, observacional, transversal y correlacional efectuado en una cohorte de pacientes con diabetes gestacional atendidas entre los meses de enero a junio del 2014 en el Hospital Militar de Especialidades de la Mujer y Neonatología de la Secretaría de la Defensa Nacional en la Ciudad de México. Se evaluó el polimorfismo mediante amplificación de un fragmento de ADN mediante la reacción en cadena de la polimerasa (PCR) y su secuenciación.
Resultados: Se estudiaron 81 pacientes; 3 de ellas con el alelo Ala, con concentraciones de glucosa menores y antecedente de más abortos en comparación con las mujeres sin el alelo Ala.
Conclusiones: La coexistencia del alelo Ala en mujeres embarazadas con diagnóstico de diabetes mellitus gestacional pudiera tener un efecto protector en contra de la hiperglucemia en el embarazo y el riesgo de aborto.


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