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Federación Mexicana de Ginecología y Obstetricia, A.C.

2023, Number 08

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Ginecol Obstet Mex 2023; 91 (08)

Evaluation of the Pro12Ala polymorphism of the PPARg gene in women with gestational diabetes mellitus

Rodríguez CD, Mejía II, Márquez AYA, Vargas HMA, Sánchez MV

Language: Spanish
References: 24
Page: 581-587
PDF size: 244.20 Kb.


ABSTRACT

Objective: To determine the frequency of peroxisomal proliferator-activated receptor gamma (PPARg) polymorphism of proline substituted with an alanine in amino acid 12 (Pro12Ala), in women with gestational diabetes mellitus and associate its impact with glycemia.
Materials and Methods: An ambispective, observational, cross-sectional and correlational study was carried out in a cohort of women with gestational diabetes that included 81 pregnant women treated at the Military Hospital for Women's Specialties and Neonatology of the Ministry of National Defense in the city from Mexico. Polymorphism was evaluated by amplification of a DNA fragment by PCR Polymerase Chain Reaction and its sequencing.
Results: The results indicated that 13.5% of the women carriers of the Ala allele also had lower blood glucose values and a history with a higher number of abortions compared to women without the Ala allele.
Conclusions: The presence of the Ala allele in pregnant women with gestational diabetes mellitus could have a protective effect against hyperglycemia in pregnancy and a risk of abortion.


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