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Revista Mexicana de Trastornos Alimentarios

2024, Número 1

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Revista Mexicana de Trastornos Alimentarios 2024; 14 (1)


Sistema endocannabinoide y la conducta alimentaria

Ramírez-Emiliano J, Ortega-Barrón IG, Caudillo-Ortega NA, Negrete-Díaz JV, Pérez-Vázquez V

Idioma: Ingles.
Referencias bibliográficas: 51
Paginas: 101-112
Archivo PDF: 402.24 Kb.


RESUMEN

El objetivo de esta revisión sistemática fue investigar en la literatura publicada previamente acerca del efecto de la dieta hipercalórica sobre el sistema endocannabinoide, el comportamiento alimentario y el desarrollo de la obesidad. En la presente revisión, analizamos y describimos la evidencia que sugiere que la regulación del sistema endocannabinoide modula la producción de anandamida, 2- araquidonoilglicerol ( 2-AG) y oleamida, y activa los receptores de endocannabinoides tipo 1 (CB1R) y/o tipo 2 (CB2R), influyendo en los centros de control del apetito y la saciedad, de esta forma induce o inhibe el consumo de alimentos hipercalóricos como los que forma parte de la dieta occidental; asimismo, hay alteración en la producción de hormonas como la grelina, la insulina, el péptido YY y la leptina. Sin embargo, hasta el momento no se han establecido las dosis adecuadas de cannabinoides puros y/o extractos hierbales enriquecidos de Cannabis para el tratamiento de trastornos alimentarios como la anorexia y/o la obesidad, ni para los trastornos del estado de ánimo.


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