Mercado CF

Idioma: Español
Referencias bibliográficas: 20
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FRAGMENTO

Introducción

La publicación de nuevos datos sobre el tolueno a través de la reciente investigación toxicocinética y toxicogenética abre nuevas perspectivas tanto en las orientaciones prácticas y el diseño del monitoreo biológico ocupacional como en la interpretación de los resultados.
Asimismo, la creciente producción de los principales hidrocarburos aromáticos en México, a pesar de la recesión económica nacional y mundial, pone de manifiesto la importancia industrial de los disolventes orgánicos (Cuadro 1).

REFERENCIAS (EN ESTE ARTÍCULO)

1. Mercado CF. Contaminantes orgánicos volátiles, pp. 301-313, Introducción a la Toxicología Ambiental, Albert Lilia, Editora, Organización Panamericana de la Salud, Organización Mundial de la Salud, Gobierno del Estado de México, Secretaría de Ecología, México 1997.

2. Löf A et al. Toxicokinetics of toluene and urinary excretion of hippuric acid after human exposure to 2H8 –toluene. Br J Ind Med 1993: 50-59.

3. Aitio A, Pekari K, Jarvisalo J. Skin abortion as a source of error in biological monitoring. Scand J Work Environ Health 1984: 10: 317.

4. Monster AC, et al. Evaluation of biological monitoring parameters for occupational exposure to toluene. Int Arch Occup. Environ Health 1993; 65: S159.

5. WHO-IPCS Environmental Health Criteria, 52: Toluene, World Health Organization, Geneva, 1985.

6. Kawamoto T, et al. Distribution of urinary hippuric acid concentrations by ALDH2 genotype. Occup Environ Med 1994; 51: 817.

7. Nise G, Orbaek P. Toluene in venous blood during and after work in rotogravure printing. Int Arch Occup Environ Health 1988; 60: 31.

8. Nise G, et al. Elimination of toluene from venous blood and adipose tissue after occupational exposure. Br J Ind Med 1989; 46: 407.

9. Nise G. Urinary excretion of o-cresol and hippuric acid after toluene exposure in rotogravure printing. Int Arch Occup Environ Health 1992; 63: 377.

10. Ogata M, Taguchi T, Horike T. Evaluation of exposure to solvents from their urinary excretions in workers co-exposed to toluene, xylene, and methyl isobuthyl ethyl ketone. Appl Occup Environ Hyg 1995; 10: 913.

11. Kawai T, et al. Toluene itself as the best urinary marker of toluene exposure. Int Arch Occup Environ Health 1996; 68: 289.

12. Angerer J, Kramer A. Occupational chronic exposure to organic solvents. III Gas chromatographic determination of hippuric acid in serum. Int Arch Arbeitsmed 1997; 34: 199.

13. Bolt HM, Roos P, Thier R. The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine. Int Arch Occup Environ Health 2003; 76: 174-185.

14. Le Marchand L, Wilkinson GR, Wilkens LR. Genetic and dietary predictors of CYP2E1 activity: a phenotyping study in Hawaii Japanese using chlorzoxazone. Cancer Epidemiology Biomarkers Prev 1999; 8: 495-500.

15. Buchet JP, Lauwerys R. Measurement of urinary hippuric acid and m-methylhippuric acids by gas chromatography. Br J Ind Med 1973; 30: 125.

16. Alvarez-Leite E, et al. Possible effects of drinking and smoking habits on hippuric acid levels in urine of adults with no occupational toluene exposure. J Occup Health 1999; 41: 112.

17. Liu SJ et al. Toluene vapor exposure and urinary excretion of hippuric acid among workers in China. Am J Ind Med 1992; 22: 313.

18. Mercado CF. Bioética en la práctica del monitoreo biológico de la exposición química laboral. Revista Latinoamericana de la Salud en el Trabajo 2003; 3(1): 25-29.

19. Takahashi S, et al. Determination of S-Benzyl-N-acetyl-L-cysteine by gas chromatography/mass spectrometry as a new marker of toluene exposure. J Anal Toxicol 1994; 18: 78.

20. Angerer J, Schildbach M, Kramer A. S-p-toluylmercapturic acid in the urine of workers exposed to toluene: a new biomarker of toluene exposure. Arch Toxicol 1998; 72: 119.