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Organo Oficial de la Sociedad Mexicana de Urología

2024, Número 2

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Rev Mex Urol 2024; 84 (2)


Adenoma negro un tumor raro de la glándula suprarrenal: presentación de caso y revisión sistemática

Padilla MI, Blanco SA, Martínez EJE, Morales CA, Manilla ME, Vizcarra MG

Idioma: Español
Referencias bibliográficas: 37
Paginas: 1-17
Archivo PDF: 275.64 Kb.


RESUMEN

Introducción: los adenomas suprarrenales negros (ASN) son tumores de la corteza suprarrenal de pigmento negro o marrón oscuro, están hechos de lipofuscina. Es un tumor raro y existen únicamente series y reportes de casos en la literatura.
Material y métodos: se realizó una revisión sistemática detallada siguiendo la guía PRISMA, de un total de 231 artículos sometidos a tamizaje, se pudieron incluir 38 pacientes.
Resultados: la edad media de presentación fue a los 46.47 años, con predominio en el sexo femenino en el 76.3 % de los pacientes, sin predilección de lateralidad de la suprarrenal afectada, con una media de tamaño de 2.9 cm, el 89.5 % fueron hipersecretores, la enfermedad de Cushing se presentó en el 76.5 % de los pacientes, 7. 9% de los pacientes tenían un feocromocitoma y 13.2 % de los pacientes tenían hiperaldosteronismo primario.
Discusión: el ASN es un tumor raro, que se presenta clínicamente como un tumor productor de hormonas en mujeres jóvenes, o en otros casos, en una tomografía como un incidentaloma, con características tomográficas que hacen sospechar patología maligna, por lo que se otorga tratamiento quirúrgico.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. Baker MR. A pigmented adenoma of the adrenal.Arch Pathol. 1938;26: 845–852.

  2. Robinson MJ, Pardo V, Rywlin AM. Pigmentednodules (black adenomas) of the adrenal:An autopsy study of incidence, morphology,and function. Human pathology. 1972;3(3):

  3. 317–325. https://doi.org/10.1016/s0046-8177(72)80033-9.3. Yu R, Wei M, Fan X, Ellis RR, BraunsteinGD. Black adrenal adenoma causingCushing’s syndrome: 40 years ago andtoday. Endocrinologia Y Nutricion: OrganoDe La Sociedad Espanola De Endocrinologia YNutricion. 2015;62(9): 466–469. https://doi.org/10.1016/j.endonu.2015.05.002.

  4. Kakkar A, Kaur K, Kumar T, Cherian LB,Kaushal R, Sharma MC, et al. PigmentedPheochromocytoma: an Unusual Variantof a Common Tumor. Endocrine Pathology.2016;27(1): 42–45. https://doi.org/10.1007/s12022-015-9407-2.

  5. Kamalanathan S, D M M, K M, Basu D. Blackadrenal adenoma: distinction from PPNAD. CaseReports. 2012;2012(jul02 1): bcr0320126076–bcr0320126076. https://doi.org/10.1136/bcr.03.2012.6076.

  6. Segura Fonseca JJ, Pirola S. Black adenomaof the adrenal gland. International Journalof Surgical Pathology. 2012;20(3): 257–259.https://doi.org/10.1177/1066896912436553.

  7. Nakajo M, Nakajo M, Kajiya Y, Tani A, TsurutaM, Sugita S, et al. A black adrenal adenomadifficult to be differentiated from a malignantadrenal tumor by CT, MRI, scintigraphy andFDG PET/CT examinations. Annals of NuclearMedicine. 2011;25(10): 812–817. https://doi.org/10.1007/s12149-011-0535-6.

  8. Inomoto C, Sato H, Kanai G, Hirukawa T,Shoji S, Terachi T, et al. Black adrenal adenomacausing preclinical Cushing’s syndrome. TheTokai Journal of Experimental and ClinicalMedicine. 2010;35(2): 57–61.

  9. Uketa S, Shimizu Y, Ogawa K, Utsunomiya N,Asai S, Ishihara M, et al. Black adrenal adenomacausing subclinical Cushing’s syndromecomplicated with pheochromocytoma. IJUcase reports. 2021;4(1): 56–58. https://doi.org/10.1002/iju5.12240.

  10. Okura T, Miyoshi K ichi, Watanabe S, KurataM, Irita J, Manabe S, et al. Coexistence of threedistinct adrenal tumors in the same adrenalgland in a patient with primary aldosteronismand preclinical Cushing’s syndrome. Clinical andExperimental Nephrology. 2006;10(2): 127–130.https://doi.org/10.1007/s10157-006-0413-z.

  11. Tanaka S, Tanabe A, Aiba M, Hizuka N,Takano K, Zhang J, et al. Glucocorticoidandandrogen-secreting black adrenocorticaladenomas: unique cause of corticotropinindependentCushing syndrome. EndocrinePractice: Official Journal of the American Collegeof Endocrinology and the American Associationof Clinical Endocrinologists. 2011;17(3): e73-78.https://doi.org/10.4158/ep.17.3.e73.

  12. Li W, Wang Y, Yang J. Laparoscopic resectionfor a left adrenal black adenoma. Chinese MedicalJournal. 2001;114(08): 879–880.

  13. Kameyama K, Takami H. Pigmented granulesin functional black adenoma of the adrenalgland: A histochemical and ultrastructuralstudy. Endocrine Pathology. 1999;10(4): 353–357. https://doi.org/10.1007/bf02739778.

  14. Odanaka M, Katabami T, Inoue M, TadokoroM. Adrenal black adenoma associated withpreclinical Cushing’s syndrome. PathologyInternational. 2003;53(11): 796–799. https://doi.org/10.1046/j.1440-1827.2003.01553.x.

  15. Matsumoto S, Hosoya Y, Lefor AK, HarutaH, Ui T, Kurashina K, et al. A black adrenaladenoma with high FDG uptake on PET/CTscan in a patient with esophageal carcinoma:A case report. International Journal of SurgeryCase Reports. 2018;44: 118–121. https://doi.org/10.1016/j.ijscr.2017.11.065.

  16. Kahara T, Seto C, Uchiyama A, Usuda D,Akahori H, Tajika E, et al. Preclinical Cushing’ssyndrome resulting from adrenal black adenomadiagnosed with diabetic ketoacidosis. EndocrineJournal. 2007;54(4): 543–551. https://doi.org/10.1507/endocrj.k06-071.

  17. Ueda Y, Tanaka H, Murakami H, NinomiyaT, Yamashita Y, Ichikawa M, et al. Afunctioning black adenoma of the adrenalgland. Internal Medicine (Tokyo, Japan).1997;36(6): 398–402. https://doi.org/10.2169/internalmedicine.36.398.

  18. Erem C, Hacihasanoglu A, Cinel A, CobanogluU, Ersöz HO, Ahmetoglu A, et al. Adrenal blackadenoma associated with Cushing’s syndrome.Endocrine. 2004;25(3): 253–257. https://doi.org/10.1385/endo:25:3:253.

  19. Takahashi S, Iijima H, Moriwaki Y, YamamotoT, Matsuoka S, Tsutsumi Z, et al. Functioningadrenal black adenoma with pulmonaryand cutaneous cryptococcosis: a case reportand review of English literature. Journal ofEndocrinological Investigation. 2001;24(10):816–819. https://doi.org/10.1007/bf03343933.

  20. Armand R, Cappola AR, Horenstein RB,Drachenberg CB, Sasano H, PapadimitriouJC. Adrenal Cortical Adenoma with ExcessBlack Pigment Deposition, Combinedwith Myelolipoma and Clinical Cushing’sSyndrome: A Case Report and Review of theLiterature. International Journal of SurgicalPathology. 2004;12(1): 57–61. https://doi.org/10.1177/10668969040120011.

  21. Tokunagaa H, Miyamura N, Sasaki K,Yoshizato K, Itasaka M, Nakamaru K, et al.Preclinical Cushing’s syndrome resulting fromblack adrenal adenoma. A case report. HormoneResearch. 2004;62(2): 60–66. https://doi.org/10.1159/000079120.

  22. Ambrosi B, Colombo P, Faglia G. Cushing’ssyndrome due to a black adenoma of theadrenal gland: lack of tumour visualization byradiocholesterol scintigraphy. European Journalof Nuclear Medicine. 1994;21(12): 1367–1368.https://doi.org/10.1007/bf02426703.

  23. Dixon RM, Lieberman LM, Gould HR, HafezGR. [131I] Iodocholesterol scintiscan and arare “functional” black adenoma of the adrenalcortex. Journal of Nuclear Medicine. 1983;24(6):505–507.

  24. Tseng CH, Chang GKJ, Wong QY, LinJI. Cushingʼs Syndrome and FunctioningAdrenal Black Adenoma: Southern MedicalJournal. 1978;71(9): 1166–1167. https://doi.org/10.1097/00007611-197809000-00035.

  25. Reschini E, Baldini M, Cantalamessa L. A blackadrenocortical adenoma causing Cushing’ssyndrome not imaged by radiocholesterolscintigraphy. European Journal of NuclearMedicine. 1990;17(3–4): 185–187. https://doi.org/10.1007/bf00811448.

  26. Caplan RH, Virata RL. Functional blackadenoma of the adrenal cortex. A rare causeof primary aldosteronism. American Journal ofClinical Pathology. 1974;62(1): 97–103. https://doi.org/10.1093/ajcp/62.1.97.

  27. Sienkowski IK, Watkins RM, Anderson VE.Primary tumorous aldosteronism due to ablack adrenal adenoma: a light and electronmicroscopic study. Journal of Clinical Pathology.1984;37(2): 143–149. https://doi.org/10.1136/jcp.37.2.143.

  28. Zaniewski M, Sheeler LR. Cushing’s syndromeassociated with functional black adenomaof the adrenal cortex. Southern MedicalJournal. 1980;73(10): 1410–1412. https://doi.org/10.1097/00007611-198010000-00038.

  29. Kato S, Masunaga R, Kawabe T, NagasakaA, Miyamoto T, Itoh M, et al. Cushing’ssyndrome induced by hypersecretionof cortisol from only one of bilateraladrenocortical tumors. Metabolism: Clinical andExperimental. 1992;41(3): 260–263. https://doi.org/10.1016/0026-0495(92)90268-f.

  30. Asakawa M, Yoshimoto T, Ota M, Numasawa M,Sasahara Y, Takeuchi T, et al. A Case of Cushing’sSyndrome with Multiple AdrenocorticalAdenomas Composed of Compact Cells andClear Cells. Endocrine Pathology. 2016;27(2):136–141. https://doi.org/10.1007/s12022-016-9423-x.

  31. Kovacs K, Horvath E, Feldman PS. Pigmentedadenoma of adrenal cortex associated withCushing’s syndrome: light and electronmicroscopic study. Urology. 1976;7(6): 641–645.https://doi.org/10.1016/0090-4295(76)90094-7

  32. Iwase K, Nagasaka A, Tsujimura T, InagakiA, Nakai A, Masunaga R, et al. Cushing’ssyndrome with cortisol hypersecretion fromone of bilateral adrenocortical adenomas: reportof a case. Surgery Today. 1994;24(6): 538–543.https://doi.org/10.1007/bf01884575.

  33. Mimou N, Sakato S, Nakabayashi H, Saito Z,Takeda R, Matsubara F. Cushing’s syndromeassociated with bilateral adrenal adenomas. ActaEndocrinologica. 1985;108(2): 245–254. https://doi.org/10.1530/acta.0.1080245.

  34. Cohen RJ, Brits R, Phillips JI, Botha JR. Primaryhyperaldosteronism due to a functional black(pigmented) adenoma of the adrenal cortex.Archives of Pathology & Laboratory Medicine.1991;115(8): 813–815.

  35. Prince EA, Yoo DC, DeLellis RA, Mayo-SmithWW. CT and PET appearance of a pigmented“black” adrenal adenoma in a patient withlung cancer. Clinical Radiology. 2007;62(12):1229–1231. https://doi.org/10.1016/j.crad.2007.04.022.

  36. Aiba M, Kawakami M, Ito Y, Fujimoto Y,Suda T, Demura H. Bilateral adrenocorticaladenomas causing Cushing’s syndrome. Reportof two cases with enzyme histochemical andultrastructural studies and a review of theliterature. Archives of Pathology & LaboratoryMedicine. 1992;116(2): 146–150.

  37. Balázs M. Functioning ‘black adenoma’ of theadrenal gland with emphasis on ultrastructuralstudies. Zentralblatt Fur Pathologie. 1991;137(2):151–156.




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