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Federación Mexicana de Ginecología y Obstetricia, A.C.

2024, Número 05

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Ginecol Obstet Mex 2024; 92 (05)


Identificación de la proteína “Spike” en sangre de cordón umbilical de recién nacidos de madres vacunadas contra SARS-CoV-2 durante el embarazo

Malfavón FM, Vázquez CEE, Borboa-Olivares HJ, Flores MMÁ, Santiago SL

Idioma: Español
Referencias bibliográficas: 34
Paginas: 189-197
Archivo PDF: 219.26 Kb.


RESUMEN

Objetivo: Identificar la coexistencia de anticuerpos contra la proteína “Spike” del SARS-CoV-2 en sangre del cordón umbilical de recién nacidos de madres vacunadas contra la COVID-19 durante el embarazo.
Materiales y Métodos: Estudio transversal, llevado a cabo en un centro de atención privada de la Ciudad de México, entre junio del 2021 y febrero del 2022, al que se incluyeron mujeres que completaron el esquema de vacunación contra SARS-CoV-2 durante el embarazo y en quienes en el trascurso de la finalización del embarazo (parto o cesárea) se haya obtenido una muestra de sangre de cordón umbilical para identificar la proteína Spike.
Resultados: Se registraron 219 pacientes y se analizaron 5 tipos de vacuna de dos plataformas diferentes; Pfizer®, Moderna®, AstraZeneca®, J&J/Janssen® y Sputnik®. La concentración de anticuerpos fue mayor en pacientes vacunadas con Moderna® y Sputnik®. Mediante el análisis de regresión de Cox se evaluó un modelo predictivo, sin mostrar diferencia estadísticamente significativa en la cantidad de anticuerpos generados luego de la primera y segunda dosis de la vacuna.
Conclusiones: La vacunación prenatal contra la COVID-19 induce una fuerte respuesta humoral materna, que se transfiere de manera efectiva al feto, incluso con una sola dosis.


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