Guerrero-Solano JA, Flores-Bazán T, Mendoza-Mojica SA, Casco-Gallardo KI, Olivo-Ramírez DP

Idioma: Ingles.
Referencias bibliográficas: 35
Paginas: 23-31
Archivo PDF: 167.13 Kb.

RESUMEN

La ansiedad, como emoción adaptativa, puede motivar a individuos a buscar soluciones y mejorar su rendimiento, pero cuando alcanza niveles clínicamente significativos, afecta significativamente la vida diaria. El presente artículo de revisión descriptiva narra la importancia del estudio de la ansiedad a través de modelos animales a nivel preclínico, destacando su relevancia en la comprensión de la neurobiología y el desarrollo de tratamientos eficaces. Se realizó una búsqueda de información científica actualizada en bases de datos relevantes para el área de la salud, de los últimos años, como PubMed, Web of Science, Embase, SciELO, Cochrane Library, Google Scholar, entre otras. En él se discuten modelos experimentales de respuesta condicionada y no condicionada, utilizados para replicar características de estos trastornos en animales de laboratorio, los cuales deben poseer validez aparente, de constructo, y predictiva. Se destaca la limitación de estos modelos para replicar la experiencia humana completa de ansiedad, así como las diferencias fisiológicas y de comportamiento entre especies. A pesar de sus limitaciones, los modelos animales siguen siendo herramientas valiosas para comprender y tratar la ansiedad, aunque se requiere más investigación para mejorar su validez y aplicabilidad clínica.

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