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Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán

2025, Number 1

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Rev Biomed 2025; 36 (1)

Between stimuli and responses: behavioral models of anxiety in animals. A descriptive review

Guerrero-Solano JA, Flores-Bazán T, Mendoza-Mojica SA, Casco-Gallardo KI, Olivo-Ramírez DP

Language: English
References: 35
Page: 23-31
PDF size: 167.13 Kb.


ABSTRACT

Anxiety, as an adaptive emotion, can motivate individuals to seek solutions and improve their performance, but when it reaches clinically significant levels, it significantly affects daily life. This descriptive review article narrates the importance of studying anxiety through animal models at the preclinical level, highlighting its relevance in understanding the neurobiology and development of effective treatments. A search for updated scientific information was conducted in relevant health-related databases from the last years, including PubMed, Web of Science, Embase, SciELO, Cochrane Library, and Google Scholar, among others. It discusses experimental models of conditioned and unconditioned responses used to replicate characteristics of these disorders in laboratory animals, which must possess face, construct, and predictive validity. It emphasized the limitation of these models in fully replicating the complete human experience of anxiety and the physiological and behavioral differences between species. Despite their limitations, animal models remain valuable tools for understanding and treating anxiety, although more research is needed to improve their validity and clinical applicability.


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