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2026, Número 1

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Med Crit 2026; 40 (1)


Sistema glinfático cerebral: de las bases a su importancia en el paciente neurocrítico

Carrillo ER, González MKI, Islas ÁRE, Palma MD

Idioma: Español
Referencias bibliográficas: 40
Paginas: 54-61
Archivo PDF: 1161.93 Kb.


RESUMEN

El sistema glinfático cerebral (SGC) es un sistema de depuración del intersticio cerebral constituido por una red de canales perivasculares, astrocitos y acuaporina 4, que tiene la función de transportar del intersticio a los vasos linfáticos meníngeos líquido cefalorraquídeo, solutos, metabolitos y neurotoxinas. La disrupción del SGC se presenta en diferentes enfermedades agudas, de las que destacan el evento vascular cerebral, trauma craneoencefálico, hemorragia subaracnoidea y el estado epiléptico, entre otras. El resultado de esta disfunción condiciona acúmulo de agua, solutos, proteína tau, β-amiloide y otros metabolitos, eventos que condicionan edema cerebral, incremento de la presión intracraneal y neurodegeneración. El objetivo de este trabajo es revisar conceptos generales relacionados con el SGC y su disfunción en el enfermo neurocrítico.


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