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>Revistas >Revista Médica del Hospital General de México >Año 2008, No. 3


Romero GMB, Lazos OM, Cruz OH, Vázquez HP, Cruz AAL, Velásquez G, Rivas VS, Feller AC
Linfomas no Hodgkin de nariz, paladar y orofaringe en pacientes del Hospital General de México
Rev Med Hosp Gen Mex 2008; 71 (3)

Idioma: Español
Referencias bibliográficas: 19
Paginas: 119-125
Archivo PDF: 427.25 Kb.

[Texto completo - PDF]

RESUMEN

Los linfomas de cavidad nasal, paladar y orofaringe comprenden un grupo heterogéneo de entidades con cuadro clínico semejante y comportamiento biológico diferente. Son poco frecuentes en Europa, Estados Unidos y comunes en Asia, así como en algunos países de América Latina, incluyendo México. Se estudiaron 43 casos. El área más afectada fue la cavidad nasal con 28 casos (65.2%), paladar siete (16.2%), orofaringe siete (16.2%) y un caso en el seno maxilar (2.3%). Los pacientes con linfomas nasales presentaron: obstrucción, epistaxis, rinorrea, dolor y sensación de masa tumoral; los de paladar: dolor, odinofagia y disfagia. Dos pacientes fueron HIV positivos. Veintisiete (62.7%) presentaron estadio clínico avanzado (etapas III y IV). Se identificaron 28 (65.2%) linfomas T/NK (natural killer); fueron de tipo blástico, pleomórfico y de células medianas y grandes, con cantidades variables de necrosis, angioinvasión y angiodestrucción. Los linfomas B correspondieron al 34.8% (15 casos); siete (46.6%) fueron difusos de células grandes, con núcleos lobulados y células anaplásicas; cinco (33.3%) presentaron células de citoplasma claro, uno células blásticas y dos (13.3%) no pudieron clasificarse. Los linfomas T/NK fueron los más frecuentes en nuestro medio con afección de las fosas nasales. La edad promedio de los pacientes fue de 42.4 años, sin predominio de sexo; los linfomas B predominaron en paladar y orofaringe, con una edad promedio de 64.4 años y con mayor afección del sexo masculino. El estadio clínico inicial al momento del diagnóstico en ambos grupos fue en etapas clínicas III y IV.


Palabras clave: Linfoma B, Linfoma T/NK, nariz, paladar, orofaringe.


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