2008, Number 3
Non Hodgkin´s lymphomas of nose, palate and oropharynx in patients at the Hospital General de México
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ABSTRACTLymphomas of the nasal cavity, palate and oropharynx comprise an heterogeneous group of entities, with similar clinical manifestations but different biologic behaviour. They are infrequent in Europe and the United States and common in Asia and in some Latin American countries included Mexico. Forty three cases were studied. The nasal cavity was the most affected area, with 28 cases (65.2%), palate 7 (16.2%), oropharynx 7(16.2%) and one case was in the maxillary sinus (2.3%). The patients with nasal lymphoma referred: obstruction, epistaxis, rhinorrhea, pain and the sensation of a tumoral mass. Those with palate involvement presented: pain, odinophagia and dysphagia. Two patients were HIV positive. Twenty seven (62.7%) were in advanced clinical stages (stages III and IV). A total of 28 (65.2%) T/NK lymphomas were identified, they were from blastic type, pleomorphic with medium and large cells as well as variable amount of necrosis, angioinvasion and angiodestruction. The B lymphomas were 34.8% (15 cases). Seven (46.6%) were large B-cell lymphoma with lobulated nucleus and anaplastic cells. Five (33.3%) cases had cells with pale cytoplasm, one case blastic cells and two (13.3%) could not be classified. The T/NK lymphomas were more frequent in our study with important affection of the nasal cavity. The average age of the patients was 42.4 years, without sex predominance, the B lymphomas predominanted in palate and oropharynx, the average were 64.4 years and with more affection in males. The clinical stages at the moment of the diagnosis in both groups were stages III and IV.
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