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2011, Número 1

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Rev Mex Cardiol 2011; 22 (1)


Etiología y fisiopatología de la diabetes mellitus tipo 2

Hernando R

Idioma: Español
Referencias bibliográficas: 55
Paginas: 39-43
Archivo PDF: 196.97 Kb.


RESUMEN

Hasta la fecha, los investigadores clínicos consideran que la etiología de la diabetes mellitus tipo 2 es desconocida. Sin embargo, hallazgos de autopsia y observaciones neuroquirúrgicos sugieren que esta enfermedad es un desorden del hipotálamo anterior y del páncreas endocrino, causado por isquemia progresiva. De esta manera, provocan tres defectos: primarios: obesidad, resistencia a la insulina y secreción inapropiada de insulina. Por consiguiente, en mi opinión, estas zonas isquémicas deben de ser revascularizadas por medio del epiplón: 1) transposición de epiplón sobre el páncreas y 2) trasplante de epiplón sobre el quiasma óptico y la bifurcación carotídea.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2010; 33(suppl 1): S62-S69.

  2. Zhang H, Zhang J, Pope ChF, Crawford LA, Vasavada RC, Jagasia SM et al. Gestacional diabetes mellitus resulting from impaired beta-cell compensation in the absence of Fox M1, a novel downstream effector of placental lactogen. Diabetes 2010; 59: 143-152.

  3. Davidson JK, DiGirolano M. Non-insulin-dependent diabetes mellitus. In: Davidson JK (ed). Clinical diabetes mellitus: A problem oriented approach. Second edition. New York; Time Medical Publ Inc 1991: 11-34.

  4. Olefsky JM. Prospects for research in diabetes mellitus. JAMA 2001; 285: 628-632.

  5. Kuri P, Álvarez C, Lavalle F, González A, Ríos J, González D y cols. Uso de insulinas en el tratamiento de la diabetes mellitus tipo 1 y 2. Rev Mex Cardiol 2007; 18: 57-86.

  6. Jermendy A, Körner A, Kovac M, Kaszas E, Balazsovic J, Szöcs A et al. Association between tell-like receptor polymorphisms and serum levels of tumor necrosis factor alpha and its soluble receptor in obese children. Med Sci Monit 2010; 16: 180-185.

  7. Lecra KI, Pauli H, Antti P. Post mortem pancreatic angiography in 45 subjects with non-insulin-dependent diabetes mellitus and 51 controls. Pancreas 1998; 16: 60-65.

  8. Jannetta PJ, Hollihan L. Type 2 diabetes mellitus, etiology and possible treatment: preliminary report. Surg Neurol 2004; 61: 422-428.

  9. Rafael H, Mego R, Moromizato P, García W, Rodriguez J. Omental transplantation for type 2 diabetes mellitus: A report of two cases. Case Rep Clin Pract Rev 2004; 5: 481-486.

  10. Rafael H. Isquemia hipotalámica y diabetes mellitus tipo 2. Rev Mex Cardiol 2007; 18: 185-187.

  11. Testud L, Latarjet A. Anatomía humana. Tomo IV. Barcelona, Salvat editores 1978: 184-710.

  12. Vandamme JPJ, Bonte J. The branches of the celiac trunk. Acta Anat 1985; 122: 110-114.

  13. Fawcett DW. A textbook of histology. Chapter 28. New York, Chapman &Hall 1994: 680-703.

  14. Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA, Butler PC. Betha-cell deficit and increased betha-cell apoptosis in human with type 2 diabetes. Diabetes 2003; 52: 102-110.

  15. Brissova M, Powers AC. Revascularization of transplanted islets: Can it be improved? Diabetes 2008; 57: 2269-2271.

  16. Rafael H, Durán MA, Oviedo I. Isquemia prancreática por aterosclerosis y diabetes mellitus tipo 2. Rev Climaterio 2002; 5: 184-187.

  17. Rafael H, Ayulo V, Lucar A. Patogenia de la aterosclerosis: Base hemodinámica y factores de riesgo. Rev Climaterio 2003; 6: 125-128.

  18. Plutzky J, Libby P. Pathophysiology of atherosclerotic heart disease. In: Tonkin AM (ed). Atherosclerosis and heart disease. London, Martin Dunitz 2003: 1-12.

  19. Texon M. The hemodynamic concept of atherosclerosis. Bull N Y Acad Med 1960; 36: 263-274.

  20. Rafael H. Cerebral atherosclerosis causes neurogenic hypertension. Stroke 2002; 33: 1180-1181.

  21. Texon M. A hemodynamic concept of atherosclerosis with particular reference to coronary occlusion. Arch Inter Med 1957: 99: 418-427.

  22. Derrik JR, Pollard HS, Moore RM. The pattern of an atherosclerotic narrowing of the celiac and superior mesenteric arteries. Ann Surg 1959; 149: 684-689.

  23. Van Bockel JH, Geelkerken RH, Wasser MN. Chronic splanchnic ischemia. Best Pract Res Clin Gastroenterol 2001; 15: 99-119.

  24. Sakorafas G, Tsiotas G, Bower T, Sarr M. Ischemic necrotizing pancreatitis: Two cases reports and review of the literature. Internal J Gastroint Cancer 1998; 24: 117-121.

  25. Rafael H. Low-back pain. J Neurosurg: Spine 2007; 7: 114-115.

  26. Rafael H. Rejuvenation after omental transplantation on the optic chiasma and carotid bifurcation. Case Rep Clin Pract Rev 2006; 7: 48-51.

  27. Brobeck JR, Best y Taylor. Bases fisiológicas de la práctica médica. Décima edición. Buenos Aires, Editoral Médica Panamericana 1981: 251-262.

  28. Liebermann-Meffert D, White H. The greater omentum: Anatomy, physiology, pathology, surgery, with an historial survey. New York, Springer-Verlag 1983: 1-369.

  29. Ye Q-F, Niu Y, She X-G, Ming Y-Z, Cheng K, Ma Y et al. Pedicled greater omentum flap for preventing bile leak in liver transplantation patients with poor biliary tract conditions. Hepatobil Pancreat Dis Inter 2007; 6: 470-477.

  30. French JD, Longmire RL, Porter RW, Movius HJ. Extravagal influences on gastric hydrochloric acid secretion induced by stress stimuli. Surgery 1953; 34: 621-632.

  31. Rafael H. Nervios craneanos. Tercera edición. México, DF, Editorial Prado 2009: 219-245.

  32. Ionescu E, Rohner-Jeanrenaud F, Berhoud HR. Increase in plasma insulin levels in response to electrical stimulation of the dorsal motor nucleus of the vagus nerve. Endocrinoloy 1983; 112: 904-910.

  33. Li Y, Jiang YC, Owyang C. Central CGRP inhibits pancreatic enzyme secretion by modulation of vagal parasympathetic outflow. Am J Physiol 1998; 275: 957-963.

  34. Rafael H. Isquemia hipotalámica por aterosclerosis y diabetes mellitus tipo 2. Rev Climaterio 2004; 7: 192-197.

  35. Dawson BH. The blood vessels of the human optic chiasma and their relation to those of the hypophysis and hypothalamus. Brain 1958; 81: 207-217.

  36. Daniel PM. The blood supply of the hypothalamus and pituitary gland. Br Med Bull 1966; 22: 202-208.

  37. Serizawa T, Saeki N, Yamaura A. Microsurgical anatomy and clinical significance of the anterior communicating artery and its perforating branches. Neurosurgery 1997; 40: 1211-1218.

  38. Finley KH. The capillary bed of the paraventricular and supraoptic nuclei of the hypothalamus. Res Publ Ass Nerv Ment Dis 1938; 18: 94-109.

  39. Felten DL, Crutcher KA. Neuronal-vascular relationships in the raphe nuclei, locus coeruleus and substantial nigra in primates. Am J Anat 1979; 155: 467-472.

  40. Landolt AM, Yasargil G, Krayenbühl H. Disturbances of the serum electrolytes after surgery of intracranial arterial aneurysms. J Neurosurg 1972; 37: 210-218.

  41. Kety SS. Human cerebral blood flow and oxygen consumption as related to aging. J Chonic Dis 1956; 3: 470-486.

  42. Rafael H. Therapeutic methods against aging. Turk J Geriatri 2010; 13: 138-144.

  43. Stein BM, McCormick WF, Rodriguez JN, Taveras JM. Postmortem angiography of cerebral vascular system. Arch Neurol 1962; 7: 545-559.

  44. Fields WS, North RR, Hass WK, Galbraith JG, Wylie EJ, Ratinov G et al. Joint study of extracranial arterial occlusion as a cause of stroke. JAMA 1968; 203: 955-960.

  45. Bullitt E, Zerg D, Mortamet B, Ghosh A, Aylward SK, Lin W et al. The effects of healthy aging on intracranial blood vessels visualized by magnetic resonance angiography. Neurobiol Aging 2010; 31: 290-300.

  46. Rafael H. Pathogenesis of overweight and obesity. Rev Climaterio 2005; 8: 233-237.

  47. Obici S, Feng Z, Arduini A, Conti R, Rossetti L. Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production. Nature Med 2003; 9: 756-761.

  48. Rafael H, Fernandez E, Ayulo V, Davila L. Weight loss following omental transplantation on the anterior perforated space. Case Rep Clin Pract Rev 2003; 4: 160-162.

  49. Blouin AM, Thannickal TC, Worley PF, Baraban JM, Reti IM, Siegel JM. Narp immunostaining of human hypocretin (orexin) neurons: Loss in narcolepsy. Neurology 2005; 65: 1189-1192.

  50. Rafael H, Mego R, Moromizato P, Espinoza M, Valadez MT. Trasplante de epiplón para la enfermedad de Alzheimer. Rev Climaterio 2000; 3: 83-89.

  51. Nishino S, Ripley B, Overeen S, Lammers GJ, Mignot E. Hypocretin (orexin) deficiency in human narcolepsy. Lancet 2000; 355: 39-40.

  52. Chaldakov GN, Stankulov IS, Hristova M, Ghenev PI. Adipobiology of disease: Adipokines and adipokine-Targeted pharmacology. Curr Pharm Design 2003; 9: 1023-1031.

  53. Bettowski J. Apelin and visfatin: Unique «beneficial» adipokines upregulated in obesity. Med Sci Monit 2006; 12: 112-119.

  54. Rafael H, Ayulo V, Mego R. Trasplante de epiplón sobre la bifurcación carotídea en contra de la hipertensión arterial esencial. Rev Mex Cardiol 2010; 21: 19-24.

  55. Rosmond R. Stress induced disturbances of the HPA axis: A pathway to type 2 diabetes? Med Sci Monit 2003; 9: 35-39.




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