Fragoso IS, Coello CP

Idioma: Español
Referencias bibliográficas: 16
Paginas: 3-8
Archivo PDF: 153.04 Kb.

RESUMEN

Debido a la necesidad de mantener la homeostasis energética en los organismos, es una prioridad para los seres vivos el contar con una enzima capaz de evaluar el contenido energético celular. En células animales, la Cinasa Activada por AMP, AMPK (por sus siglas en inglés) es una enzima que regula algunos procesos metabólicos de acuerdo al estado energético; se activa durante el ejercicio, diabetes tipo II, obesidad y anoxia por lo que ha sido propuesta como un regulador metabólico durante condiciones energéticas anormales. Esta enzima es un complejo heterotrimérico que se activa alostéricamente por AMP, sin embargo para su completa activación necesita ser fosforilada por una cinasa río arriba conocida como LKB1. En todos los eucariontes analizados se encuentran complejos ortólogos a AMPK, lo que sugiere una alta conservación funcional en el control metabólico.

REFERENCIAS (EN ESTE ARTÍCULO)

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