Fragoso IS, Coello CP

Language: Spanish
References: 16
Page: 3-8
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ABSTRACT

Energetic homeostasis is a priority for all the organisms. Therefore, it is very important to have an enzyme capable of evaluating the changes in energetic status. In animal cells, the AMP Activated Kinase (AMPK) is an enzyme that regulates some metabolic pathways according to the energetic status. This enzyme is activated during exercise, type II diabetes, obesity and anoxia, and it has been postulated as a metabolic regulator during abnormal energetic conditions. This enzyme is a heterotrimeric complex that is activated allosterically by AMP; however, for a complete activation, it needs to be phosphorylated by an upstream kinase, LKB1. There have been found orthologs to AMPK in all the eukaryotes analyzed so far, suggesting a high functional conservation in the metabolic control.

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