García-Rivas GJ

Idioma: Español
Referencias bibliográficas: 22
Paginas: 20-25
Archivo PDF: 167.44 Kb.

RESUMEN

Una de las estrategias más efectivas para proteger al corazón del daño por reperfusión es someterlo a uno o varios períodos cortos de isquemia antes de una isquemia prolongada y severa, que pueda conducir al daño miocárdico y a la muerte celular. Esta estrategia conocida como precondicionamiento isquémico (PCI) se basa en la activación de diversos mecanismos cuya importancia se encuentra actualmente bajo discusión. Se ha sugerido que los canales mitocondriales de potasio sensibles a ATP, participan en la protección derivada del PCI. En esta revisión se presenta información reciente que sustenta esta hipótesis y enfatiza la modulación farmacológica de este tipo de canales.

REFERENCIAS (EN ESTE ARTÍCULO)

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