García-Rivas GJ

Language: Spanish
References: 22
Page: 20-25
PDF size: 167.44 Kb.

ABSTRACT

Ischemic preconditioning (IPC) is an effective strategy for reducing heart damage triggered by ischemia reperfusion. IPC consists of exposing heart to a single or multiple brief periods of ischemia before the occurrence of a more prolonged ischemic insult, which otherwise would lead to massive myocardial damage and cell death. Comprehensive data suggest the participation of ATP-sensitive potassium channels in IPC protection. Although these type of channels are present in both the sarcolemmal and the inner mitochondrial membrane of heart cells, the evidence reviewed here suggest that the mitochondrial channels and not the sarcolemma channels, contribute to the cardioprotection. The pharmacological modulation of these channels is emphasized.

REFERENCES

1. Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS (2003) International Union of Pharmacology XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev 55:583-6.

2. Noma A (1983) ATP-regulated K+ channels in cardiac muscle. Nature 305:147-8.

3. Yao Z, Gross GJ (1994) Effects of the KATP channel opener bimakalim on coronary blood flow, monophasic action potential duration, and infarct size in dogs. Circulation 89:1769-75.

4. Inoue I, Nagase H, Kishi K, Higuti T (1991) ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature 352:244-7.

5. Paucek P, Mironova G, Mahdi F, Beavis AD, Woldegiorgis G, Garlid KD (1992) Reconstitution and partial purification of the glibenclamide-sensitive, ATPdependent K+ channel from rat liver and beef heart mitochondria. J Biol Chem 267:26062-9.

6. Poupa O, Krofta K, Prochazka J, Turek Z (1966) Acclimation to simulated high altitude and acute cardiac necrosis. Fed Proc 25:1243-6.

7. Murry CE, Jennings RB, Reimer KA (1986) Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74:1124-36.

8. Garlid KD, Paucek P, Yarov-Yarovoy V, Murray HN, Darbenzio RB, D'Alonzo AJ, Lodge NJ, Smith MA, Grover GJ (1997) Cardioprotective effect of diazoxide and its interaction with mitochondrial ATP-sensitive K+ channels. Possible mechanism of cardioprotection. Circ Res. 81:1072- 82.

9. Liu Y, Ren G, O'Rourke B, Marban E, Seharaseyon J (2001) Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. Mol Pharmacol. 59:225-30.

10. Jung O, Englert HC, Jung W, Gogelein H, Scholkens B A, Busch AE, Linz W (2000) The K(ATP) channel blocker HMR 1883 does not abolish the benefit of ischemic preconditioning on myocardial infarct mass in anesthetized rabbits. Naunyn Schmiedebergs Arch Pharmacol 361:445-51.

11. D'hahan N, Moreau C, Prost AL, Jacquet H, Alekseev AE, Terzic A, Vivaudou M (1999) Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP. Proc Natl Acad Sci USA 96:12162-7.

12. Liu Y, Sato T, O'Rourke B, Marban E (1998) Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation 97:2463-9.

13. Holmuhamedov EL, Wang L, Terzic A (1999) ATPsensitive K+ channel openers prevent Ca2+ overload in rat cardiac mitochondria. J Physiol 519:347-60.

14. García-Rivas GJ, Guerrero-Hernández A, Guerrero-Serna G, Rodríguez -Zavala JS, Zazueta C (2005) Inhibition of mitochondrial calcium uniporter by oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in post-ischemic rat heart. FEBS J 272:3477-88.

15. Forbes RA, Steenbergen C, Murphy E (2001) Diazoxideinduced cardioprotection requires signaling through a redox-sensitive mechanism. Circ Res 88:802-9.

16. Zweier JL, Flaherty JT, Weisfeldt ML (1987) Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci USA84:1404-7.

17. Crompton M, Costi A (1990). A heart mitochondrial Ca2+- dependent pore of possible relevance to re-perfusioninduced injury. Evidence that ADP facilitates pore interconversion between the closed and open states. Biochem J 266:33-9.

18. Hausenloy D, Wynne A, Duchen M, Yellon D (2004) Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection. Circulation 109:1714-7.

19. Suzuki M, Kotake K, Fujikura K, Inagaki N, Suzuki T, Gonoi T, Seino S, Takata K (1997) Kir6.1: a possible subunit of ATP-sensitive K+ channels in mitochondria. Biochem Biophys Res Commun 241:693-7.

20. Seharaseyon J, Ohler A, Sasaki N, Fraser H, Sato T, Johns D C, O'Rourke B, Marban E (2000) Molecular composition of mitochondrial ATP-sensitive potassium channels probed by viral Kir gene transfer. J Mol Cell Cardiol 32:1923-30.

21. Grover GJ, Garlid KD (2000) ATP-Sensitive potassium channels: a review of their cardioprotective pharmacology. J Mol Cell Cardiol 32:677-95.

22. Ardehali H, Chen Z, Ko Y, Mejia-Alvarez R, Marban E (2004) Multiprotein complex containing succinate dehydrogenase confers mitochondrial ATP-sensitive K+ channel activity. Proc Natl Acad Sci USA 101:11880-5.