Revista de Investigación Clínica

Contenido por año, Vol. y Num.

Índice de este artículo

Información General

Instrucciones para Autores

Mensajes al Editor


>Revistas >Revista de Investigación Clínica >Año 2011, No. 2

Irving R, Tusié-Luna MT, Mills J, Wright-Pascoe R, McLaughlin W, Aguilar-Salinas CA
Diabetes tipo 2 de inicio temprano en Jamaica y en México. Oportunidades derivadas de un estudio interétnias
Rev Invest Clin 2011; 63 (2)

Idioma: Inglés
Referencias bibliográficas: 67
Paginas: 198-209
Archivo PDF: 120.20 Kb.

Texto completo


Poblaciones con ancestría amerindia o africana son las que tienen la mayor prevalencia de diabetes en el mundo. Un alto porcentaje de sus fundadores estuvieron expuestos a la hambruna. Los fenómenos que les permitieron sobrevivir son patogénicos para sus descendientes que viven en un ambiente con exceso de calorías. En países como México y Jamaica en los que la diabetes tiene una prevalencia alta, la enfermedad inicia a edades menores. Nuestro objetivo es revisar la información sobre diabetes en Mexico y Jamaica, además de discutir las oportunidades que ofrece un estudio interétnico para brindar información nueva de la genética de la diabetes. La prevalencia de diabetes en Jamaica es 17.9% en los mayores de 15 años. Los investigadores de Jamaica tienen una cohorte de familias con diabetes tipo 2 de inicio temprano, en quienes se ha excluido anormalidades en los genes MODY. Por otra parte, la prevalencia de diabetes en adultos Mexicanos es de 14.4%. El grupo de edad en que ha ocurrido un cambio mayor en la prevalencia es el compuesto por menores de 40 años. Más de dos terceras partes de los casos de inicio temprano estudiados en población abierta tienen un índice de masa corporal › 25 kg/m2 y las características clínicas del síndrome metabólico. Una minoría tienen mutaciones en los genes MODY. El estudio conjunto de las cohortes de México y Jamaica de pacientes con diabetes de inicio temprano será útil para identificar nuevos factores genéticos y ambientales que participan en la patogénesis de la diabetes.

Palabras clave: Diabetes tipo 2 de inicio temprano, México, Jamaica, Diabetes del joven de tipo del adulto, Obesidad.


  1. García-García E, Aguilar-Salinas CA, Tusié-Luna MT, Rull- Rodrigo JA. Early onset type 2 diabetes in México. Israel Med Assoc J 2002; 4: 444-8.

  2. Tulloch-Reid MK, Boyne MS, Smikle MF, et al. Cardiovascular risk profile in Caribbean youth with diabetes mellitus.West Indian Med J 2009; 58: 219-26.

  3. Song SH, Hardisty CA. Early onset type 2 diabetes mellitus: a harbinger for complications in later years-clinical observation from a secondary care cohort. QJM 2009; 102: 799-806.

  4. Smith TL, Drum ML, Miernik J, Fogelfeld LA, Lipton RB. Early and later onset type 2 diabetes in uninsured patients: clinical and behavioral differences. J Health Care Poor Underserved 2008; 19: 1119-35.

  5. O’Rahilly S, Spivey RS, Holman RR, Nuggent Z, Clark A, Turner RC. Type II diabetes of early onset: A distinct clinical and genetic syndrome? Br Med J 1987; 294: 923-8.

  6. Prudente S, Scarpelli D, Chandalia M, et al. The TRIB3 Q84R polymorphism and risk of early-onset type 2 diabetes. J Clin Endocrinol Metab 2009; 94: 190-6.

  7. Hatunic M, Burns N, Finucane F, Mannion C, Nolan JJ. Contrasting clinical and cardiovascular risk status between early and later onset type 2 diabetes. Diab Vasc Dis Res 2005; 2: 73-5.

  8. Kim KS, Oh HJ, Kim JW, et al.The clinical characteristics of the newly diagnosed early onset (< 40 years old) diabetes in outpatients’ clinic. Korean Diab J 2010; 34: 119-25.

  9. Meur G, Simon A, Harun N, et al. PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians. Diab 2008; 57: 3156-60.

  10. McQuaid S, O’Gorman D, Yousif O, et al. Early-Onset Insulin- Resistant Diabetes in Obese Caucasians Has Features of Typical Type 2 Diabetes, but 3 Decades Earlier. Diab Care 2005; 28: 1216-18.

  11. Burns N, Finucane FM, Hatunic H, et al. Early-onset type 2 diabetes in obese white subjects is characterised by a marked defect in beta cell insulin secretion, severe insulin resistance and a lack of response to aerobic exercise training. Diabetol 2007; 50: 1500-08.

  12. Hernandez Alvarez MI, Thabit H.Burns N, et al. Subjects with early-onset type 2 diabetes show defective activation of the skeletal muscle PGC-1_/Mitofusin-2 regulatorypathway in response to physical activity. Diab Care 2010; 33: 645-51.

  13. Gat-Yablonski G, Shalitin S, Phillip M. Maturity onset diabetes of the young:review. Pediatr Endocrinol Rev 2006; 3(Suppl. 3): 514-20.

  14. Unnikrishnan AG, Bhatia E, Bhatia V, et al. Type 1 diabetes versus Type 2 diabetes with onset in persons younger than 20 years of age. Results from an Indian multicenter study. Ann NY Acad Sci 2008; 1150: 239-44.

  15. Soriano S, González A, Marroquí L, et al. Reduced insulin secretion in protein malnourished mice is associated with multiple changes in the beta-cell stimulus-secretion coupling. Endocrinol 2010; 151: 3543-54.

  16. Díaz-Villaseñor A, Burns AL, Salazar AM, et al. Arsenite reduces insulin secretion in rat pancreatic beta-cells by decreasing the calcium-dependent calpain-10 proteolysis of SNAP-25. Toxicol Appl Pharmacol 2008; 231: 291-9.

  17. Gómez-Pérez FJ, Mehta R. Genetic defects of beta cell function: (MODY) application of molecular biology to clinical medicine. Rev Invest Clin 2003; 55: 172-6.

  18. Vaxillaire M, Froguel P Monogenic forms of diabetes mellitus: an update. Endocrinol Nutr 2009; 56(Suppl. 4): S26-S29.

  19. Mohan V, Jaydip R, Deepa R. Type 2 diabetes in Asian Indian youth. Pediatr Diab 2007; 8(Suppl. 9): S28-S34.

  20. Doria A, Yang Y, Malecki M. Phenotypic characteristics of early-onset autosomal-dominant type 2 diabetes unlinked to known maturity-onset diabetes of the young (MODY) genes. Diab Care 1999; 22: 253-60.

  21. Meigs J. Epidemiology of Type 2 Diabetes and cardiovascular disease: Translation from population to prevention. Diab Care 2010; 33: 1865-71.

  22. Voight B, Scott L, Steinthorsdottir V, et al Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nature Genetics 2010; 42: 579-81.

  23. Dupuis J, Langenberg C, Prokopenko I, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010; 42: 105-15.

  24. Elbein S. Genetics Factors Contributing to Type 2 Diabetes across Ethnicities. J Diab Science and Technology 2009: 3; 685-9.

  25. Parra EJ, Cameron E, Simmonds L, Valladares A, McKeigue P, Shriver M, et al. Association of TCF7L2 polymorphisms with type 2 diabetes in Mexico City.Clin Genet 2007; 71: 359-66.

  26. Baier L, Hanson R. Genetic studies of the etiology of type 2 diabetes in Pima indians:Hunting for pieces to a complicated puzzle. Diab 2004; 53: 1181-6.

  27. Ma L, Hanson RL, Que L, et al. PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima indians. Diab 2008; 57: 3156-60.

  28. Guo T, Hanson RL, Traurig M, et al. TCF7L2 is not a major susceptibility gene for type 2 diabetes in Pima indians. Analysis of 3,501 individuals. Diab 2008; 56: 3082-8.

  29. Bian L, Hanson RL, Muller Y, et al. Variants in ACAD10 are associated with type 2 diabetes, insulin resistance and lipid oxidation in Pima Indians. Diabetol 2010; 53: 1349-53.

  30. Milicic A, Lindheimer F, Laval S, et al. Interethnic studies of TNF polymorphisms confirm the likely presence of a second MHC susceptibility locus in ankylosing spondylitis. Genes and Immunity 2000; 1: 418-22.

  31. Mesa NR, Mondragon MC, Soto ID, et al. Autosomal, mtDNA, and Y-chromosome diversity in Amerinds: pre- and post-Columbian patterns of gene flow in South America. Am J Hum Genet 2000; 67: 1277-86.

  32. Parra EJ, Marcini A, Akey J, et al. Estimating African American admixture proportions by use of population-specific alleles. Am J Hum Genet 1998; 63: 1839-51.

  33. Halder I, Shriver MD. Measuring and using admixture to study the genetics of complex diseases. Hum Genomics 2003; 1: 52-62.

  34. Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes: Estimates for the year 2000 and projections for 2030. Diab Care 2004; 27: 1047-53.

  35. Kuller LH. Ethnic differences in atherosclerosis, cardiovascular disease and lipid metabolism. Curr Opin Lipidol 2004; 15: 109-13.

  36. Pavkov ME, Bennett PH, Knowler WC, Krakoff J, Sievers ML, Nelson RG. Effect of youth-onset type 2 diabetes mellitus on incidence of end-stage renal disease and mortality in young and middle-aged Pima Indians. JAMA 2006; 296: 421-6.

  37. Rosenbloom AL, Young RS, Joe JR, Winter WE. Emerging epidemic of type 2 diabetes in youth. Diab Care 1999; 22: 345-54.

  38. Morrison EY, Ragoobirsingh D, Peter SA. The Unitarian Hypothesis for the aetiology of diabetes mellitus. Med Hypotheses 2006; 67: 1115-20.

  39. Rull JA, Aguilar-Salinas CA, Rojas R, Ríos-Torres JM, Gómez- Pérez FJ, Olaiz G. Epidemiology of type 2 diabetes in Mexico. Arch Med Res 2005; 36: 188-96.

  40. Available from: www.uwi.edu/territories/jamaica.aspx [Accessed on March 8, 2010].

  41. Available from: www.en.wikipedia.org/wiki/ Demographics_of_Jamaica#cite_note-university-2 [Accessed on March 8, 2010].

  42. Hugh-Jones P. Diabetes in Jamaica. Lancet 1955; ii: 891-97.

  43. Mills JL, Irving RR, Choo-Kang EG, Wright-Pascoe R, McLaughlin W, Mullings AA, et al. Multigenerational inheritance and clinical characteristics of three large pedigrees with early-onset type 2 diabetes in Jamaica. Rev Panam Sal Púb 2010; 27: 435-41.

  44. Barceló A, Aedo C, Rajpathak S, Robles S. The cost of diabetes in Latin America and the Caribbean. Bull World Health Org 2003; 81: 19-27.

  45. Ragoobirsingh D, Morrison EY, Johnson P, Lewis-Fuller E. Obesity in the Caribbean: the Jamaican experience. Diab Obes Metab 2004; 6: 23-7.

  46. Durazo-Arvizu RA, Luke A, Cooper RS, et al. Rapid increases in obesity in Jamaica, compared to Nigeria and the United States. BMC Public Health 2008; 8: 133.

  47. Ferguson TS, Younger NO, Tulloch-Reid MK, et al. Prevalence of prehypertension and its relationship to risk factors for cardiovascular disease in Jamaica: analysis from a cross-sectional survey. BMC Cardiovasc Disord 2008; 8: 20.

  48. Irving RR, Mills JL, Choo-Kang EG, Morrison EY, Kulkarni S, Wright-Pascoe R, Mclaughlin W. The burden of gestational diabetes mellitus in Jamaican women with a family history of autosomal dominant type 2 diabetes. J Pan American Health Organization 2008; 23: 85-91.

  49. Sinsheimer J, Plaisier C, Huertas-Vázquez A, et al. Estimating Ethnic Admixture from Pedigree Data. Am J Human Genetics 2008; 82: 748-55.

  50. Available from: www.inegi.org.mx/Default.aspx [Accessed on March 8, 2010].

  51. Córdova-Villalobos JA, Barriguete-Meléndez JA, Lara-Esqueda A, et al. Chronic non-communicable diseases in Mexico: epidemiologic synopsis and integral prevention. Sal Púb Méx 2008; 50: 419-27.

  52. Aguilar-Salinas CA, Rojas R, Gómez-Pérez FJ, et al. High prevalence of the metabolic syndrome in México. Arch Med Res 2004; 35: 76-81.

  53. Aguilar-Salinas CA, Velázquez Monroy O, Gómez-Pérez FJ, et al. Characteristics of the patients with type 2 diabetes in México: results from a large population-based, nation-wide survey. Diab Care 2003: 26: 2021-6.

  54. Villalpando S, Rojas R, Shamah-Levy T, et al. Prevalence and distribution of type 2 Diabetes mellitus tipo 2 in Mexican adult population. A probabilistic survey. Sal Púb Méx 2010: 52 (Suppl. 1): S19-S26.

  55. Escobedo J, Buitrón LV, Velasco MF, et al. High prevalence of diabetes and impaired fasting glucose in urban Latin America: the CARMELA Study. Diabet Med 2009; 26: 864-71.

  56. Lorenzo C, Serrano-Ríos M, Martínez-Larrad MT, et al. Which obesity index best explains prevalence differences in type 2 diabetes mellitus? Obesity 2007; 15: 1294-301.

  57. Aguilar-Salinas CA, Rojas R, Gómez-Pérez FJ, et al. Early-onset type 2 diabetes in a Mexican, population-based, nationwide survey. Am J Med 2002; 113: 569-74.

  58. Jiménez CA, Rojas MR, Gómez-Pérez FJ, Aguilar-Salinas CA. Early onset type 2 diabetes in a Mexican, populationbased, nation-wide survey: Results of the Encuesta Nacional de Salud y Nutrición 2006. Sal Púb Méx 2010: 52 (Suppl. 1): S27-S35.

  59. Ramachandran A, Snehalatha C, Kapur A, et al. Diabetes Epidemiology Study Group in India (DESI). High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey. Diabetol 2001; 44: 1094-101.

  60. Ríos Burrows N, Geiss L, Engelgau M, Acton K. Prevalence of diabetes among native American and Alaska natives 1990- 1997. Diab Care 2000; 23: 1786-90.

  61. Aguilar-Salinas CA, Reyes-Rodríguez E, Ordóñez-Sánchez ML, et al. Early-Onset Type 2 Diabetes: Metabolic and Genetic Characterizarion in Mexican Population. J Clin Endoc Metab 2001; 86: 220-6.

  62. Del Bosque-Plata L, Aguilar-Salinas CA, Tusié-Luna MT, et al. Association of the Calpain-10 Gene with Type 2 Diabetes Mellitus in a Mexican Population. Molecular Genetics and Metabolism 2004; 81: 122-6.

  63. Burguete-García AI, Cruz-López M, Madrid-Marina V, et al. Association of Gly972Arg polymorphism of IRS1 gene with type 2 diabetes mellitus in lean participants of a national health survey in Mexico: a candidate gene study. Metabolism 2010; 59: 38-45.

  64. Menjívar M, Granados-Silvestre MA, Montúfar-Robles I, et al. High frequency of T130I mutation of HNF4A gene in Mexican patients with early onset type 2 diabetes. Clin Genet 2008; 73: 185-7.

  65. Villarreal-Molina MT, Flores-Dorantes MT, Arellano-Campos O, et al. Association of the ABCA1 R230C Variant with Early- Onset Type 2 Diabetes in the Mexican Population. Diab 2008; 57: 509-13.

  66. Hoggart CJ, Shriver MD, Kittles RA, Clayton DG, McKeigue- PM. Design and analysis of admixture mapping studies. Am J Hum Genet 2004; 74: 965-78.

  67. Patterson N, Hattangadi N, Lane B, et al. Methods for highdensity admixture mapping of disease genes. Am J Hum Genet 2004; 74: 979-1000.

>Revistas >Revista de Investigación Clínica >Año2011, No. 2

· Indice de Publicaciones 
· ligas de Interes 

Derechos Resevados 2019