Entrar/Registro  
INICIO ENGLISH
 
Gaceta Médica de México
   
MENÚ

Contenido por año, Vol. y Num.

Índice de este artículo

Información General

Instrucciones para Autores

Mensajes al Editor

Directorio






>Revistas >Gaceta Médica de México >Año 2013, No. 2


Balas-Nakash M, Perichart-Perera O, Benítez-Arciniega A, Tolentino-Dolores M, Mier-Cabrera J, Vadillo-Ortega F
Asociación entre adiposidad, inflamación y factores de riesgo cardiovascular en un grupo de escolares mexicanos
Gac Med Mex 2013; 149 (2)

Idioma: Español
Referencias bibliográficas: 45
Paginas: 196-203
Archivo PDF: 114.91 Kb.


Texto completo




RESUMEN

Objetivo: Evaluar las diferencias en marcadores de inflamación y riesgo cardiovascular en escolares con y sin adiposidad excesiva, así como la asociación entre la inflamación y los factores de riesgo cardiovascular. Material y métodos: Estudio transversal (n = 285 niños; edad: 8-12 años). Se midió la adiposidad (índice de masa corporal [IMC], grasa corporal y circunferencia de cintura [CCin]), inflamación (proteína C reactiva [PCR], interleucina 1β [IL-1β], interleucina 6 [IL-6] y factor de necrosis tumoral α [TNF-α]) y riesgo cardiovascular. Se realizó estadística descriptiva, diferencias de medias y modelos de regresión múltiple. Resultados: Los escolares con obesidad presentaron mayores concentraciones de PCR e IL-1β, y aquellos con obesidad abdominal mayores concentraciones de PCR. Las concentraciones de PCR e IL-1β se correlacionaron con los tres indicadores de adiposidad. Las concentraciones de IL-6 se asociaron con las concentraciones de triacilglicéridos (TAG) y las de IL-1β con las de colesterol unido a lipoproteínas de alta densidad (C-HDL), ajustado por IMC. Discusión: En este grupo de escolares mexicanos, la obesidad aumentó el riesgo cardiovascular y algunos marcadores de inflamación. Las concentraciones de IL-6 e IL-1β parecen ser factores que participan en la alteración de lípidos, independientemente de la presencia de obesidad. Se requieren más estudios que exploren el papel de la inflamación subclínica en el desarrollo de alteraciones cardiovasculares ya descritas en niños mexicanos con obesidad.


Palabras clave: Inflamación, Adiposidad, Riesgo cardiovascular, Obesidad, Escolares.


REFERENCIAS

  1. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics. 1999;103:1175-82.

  2. Del Río-Navarro BE, Velázquez-Monroy O, Sánchez-Castillo CP, et al. The high prevalence of overweight and obesity in Mexican children. Obes Res. 2004;12(2):215-23.

  3. Perichart-Perera O, Balas-Nakash M, Schiffman-Selechnik E, Barbato- Dosal A, Vadillo-Ortega F. Obesity increases metabolic syndrome risk factors in school-aged children from an urban school in Mexico city. J Am Diet Assoc. 2007;107(1):81-91.

  4. American Heart Association Scientific Statement. Diet and lifestyle recommendations. Revision 2006. A scientific statement from the American Heart Association Nutrition Committee. Circulation. 2006;114:82-96.

  5. Wang Z, Nakayama T. Inflammation, a link between obesity and cardiovascular disease. Mediators Inflamm. 2010;2010:535918.

  6. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363-9.

  7. Kones R. Primary prevention of coronary heart disease: integration of new data, evolving views, revised goals, and role of rosuvastatin in management. A comprehensive survey. Drug Des Devel Ther. 2011;5:325-80.

  8. Wozniak SE, Gee LL, Wachtel MS, Frezza EE. Adipose tissue: the new endocrine organ? A review article. Dig Dis Sci. 2009;54(9):1847-56.

  9. Akinci G, Akinci B, Coskun S, Bayindir P, Hekimsoy Z, Ozmen B. Evaluation of markers of inflammation, insulin resistance and endothelial dysfunction in children at risk for overweight. Hormones. 2008;7(2):156-62.

  10. Caballero AE, Bousquet-Santos K, Robles-Osorio L, et al. Overweight Latino children and adolescents have marked endothelial dysfunction and subclinical vascular inflammation in association with excess body fat and insulin resistance. Diabetes Care. 2008;31(3):576-82.

  11. Roh EJ, Lim JW, Ko KO, Cheon EJ. A useful predictor of early atherosclerosis in obese children: serum high-sensitivity C-reactive protein. J Korean Med Sci. 2007;22(2):192-7.

  12. De Ferranti SD, Gauvreau K, Ludwig DS, Newburger JW, Rifai N. Inflammation and changes in metabolic syndrome abnormalities in US adolescents: findings from the 1988-1994 and 1999-2000 National Health and Nutrition Examination Surveys. Clin Chem. 2006;52(7):1325-30.

  13. Gillum RF. Association of serum C-reactive protein and indices of body fat distribution and overweight in Mexican American children. J Natl Med Assoc. 2003;95(7):545-52.

  14. Dos Santos MG, Pegoraro M, Sandrini F, Macuco EC. Risk factors for the development of atherosclerosis in childhood and adolescence. Arq Bras Cardiol. 2008;90(4):276-83.

  15. Shea S, Aymong E, Zybert P, et al. Obesity, fasting plasma insulin, and C-Reactive protein levels in healthy children. Obes Res. 2003; 11(1):95-103.

  16. Soriano-Guillen L, Hernández-García B, Pita J, Domínguez-Garrido N, Del Río-Camacho G, Rovira A. High-sensitivity C-reactive protein is a good marker of cardiovascular risk in obese children and adolescents. Eur J Endocrinol. 2008;159(1):R1-4.

  17. Wu DM, Chu NF, Shen MH, Wang SC. Obesity, plasma high sensitivity C-reactive protein levels and insulin resistance status among school children in Taiwan. Clin Biochem. 2006;39(8):810-5.

  18. Lambert M, Delvin EE, Paradis G, O’Loughlin J, Hanley JA, Levy E. C-reactive protein and features of the metabolic syndrome in a population- based sample of children and adolescents. Clin Chem. 2004; 50(10):1762-8.

  19. Galcheva S, Lotova V, Yotov Y, Bernasconi S, Street M. Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children. Eur J Endocrinol. 2011;164(4):553-8.

  20. Moran A, Steffen L, Jacobs D, et al. Relation of C-reactive protein to insulin resistance and cardiovascular risk factors in youth. Diabetes Care. 2005;28:1763-8.

  21. Goldaracena-Azuara M, de la Cruz-Mendoza E, Flores-Sánchez J, Vargas- Morales JM, Aradillas-García C. Resistencia a la insulina E Interleucina- 6, Factor de necrosis tumoral ALFA en población infantil de San Luis Potosí. Resúmenes de trabajos libres. Bioquimia. 2005;30(Suppl A):135.

  22. Balas-Nakash M, Benítez-Arciniega A, Perichart-Perera O, Valdés-Ramos R, Vadillo-Ortega F. The effect of exercise on cardiovascular risk markers in Mexican school-aged children: comparison between two structured group routines. Salud Pública de Mex. 2010;52(5):398-405.

  23. Pearson TA, Mensah GA, Alexander RW, et al. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation. 2003;107(3):499-511.

  24. Lohman T, Roche A, Martorell R. Anthropometric standardization reference manual. Champaign, IL.: Human Kinetics Books; 1991.

  25. Kuczmaski R, Oqden C, Grummer-Strawn L, et al. CDC growth charts: United States. Advance data. 2000;314(1):1-27.

  26. Williams D, Going S, Lohman T, et al. Body fatness and risk for elevated blood pressure, total cholesterol, and serum lipoprotein ratios in children and adolescents. Am J Public Health. 1992;82(3):358-63.

  27. Expert Panel on the Identification and Treatment of Overweight in Adults. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults. National Institutes of Health. EE.UU., 1998.

  28. Klunder-Klunder M, Flores-Huerta S. Waist circumference values according to height percentiles: A proposal to evaluate abdominal obesity in Mexican children and adolescents between 6 and 16 years of age. Arch Med Res. 2011;42(6):515-22.

  29. Brasil AR, Norton RC, Rossetti MB, Leao E, Mendes RP. C-reactive protein as an indicator of low intensity inflammation in children and adolescents with and without obesity. J Pediatr. 2007;83(5):477-80.

  30. Kim J, Bhattacharjee B, Kheirandish-Gozal L, et al. Insulin sensitivity, serum lipids, and systemic inflammatory markers in school-aged obese and nonobese children. Int J Pediatr. 2010;2010:846098.

  31. Álvarez JA, Higgins PB, Oster RA, Férnandez JR, Darnell BE, Gower BA. Fasting and postprandial markers of inflammation in lean and overweight children. Am J Clin Nutr. 2009;89:1138-44.

  32. Revenga-Frauca J, González-Gil EM, Bueno-Lozano G, et al. Abdominal fat and metabolic risk in obese children and adolescents. J Physiol Biochem. 2009;65(4):415-20.

  33. Ford ES, Ajani UA, Mokdad AH; National Health and Nutrition Examination. The metabolic syndrome and concentrations of C-reactive protein among U.S. youth. Diabetes Care. 2005;28(4):878-81.

  34. Warnberg J, Nova E, Moreno L, et al. Inflammatory proteins are related to total and abdominal adiposity in a healthy adolescent population: the AVENA Study. Am J Clin Nutr. 2006;84:505-12.

  35. Kelishadi R, Sharifi M, Khosravi A, Adeli K. Relationship between Creactive protein and atherosclerotic risk factors and oxidative stress markers among young persons 10-18 years old. Clin Chem. 2007;53(3):456-64.

  36. Hardardóttir I, Moser AH, Memon R, Grünfeld C, Feingold KR. Effects of TNF, IL-1, and the combination of both cytokines on cholesterol metabolism in Syrian hamsters. Lymphokine Cytokine Res. 1994;13(3):161-6.

  37. Argiles JM, López-Soriano FJ, Evand RD, Williamson DH. Interleukin-1 and lipid metabolism in rat. Biochem J. 1989;259:673-8.

  38. Cartier A, Lemieux I, Almeras N, Tremblay A, Bergeron J, Despres JP. Visceral obesity and plasma glucose-insulin homeostasis: contributions of interleukin-6 and tumor necrosis factor-alpha in men. J Clin Endocrinol Metab. 2008;93(5):1931-8.

  39. Beasley L, Koster A, Newman A, et al. Inflammation and race and gender differences in computerized tomography-measured adipose depots. Obesity. 2009;17:1062-9.

  40. Pou K, Massaro J, Hoffmann U, et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress. The Framingham Heart Study. Circulation. 2007;116:1234-41.

  41. Yeste D, Vendrell J, Tomasini R, et al. Interlukin-6 in obese children and adolescents with and without glucose intolerance. Diabetes Care. 2007;30(7):1892-4.

  42. Fernández-Real J, Broch M, Vendrell J, Richart C, Ricart W. Interleukin-6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab. 2000;85:1334-9.

  43. Mendall M, Parel P, Asante M, et al. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart. 1997;78(3):273-7.

  44. Ford ES, Galuska DA, Gillespie C, Will JC, Giles WH, Dietz WH. C-reactive protein and body mass index in children: findings from the Third National Health and Nutrition Examination Survey, 1988-1994. J Pediatr. 2001;138(4):486-92.

  45. Dixon D, Goldberg R, Schneiderman N, Delamater A. Gender differences in TNF-alpha levels among obese vs nonobese Latino children. Eur J Clin Nutr. 2004;58(4):696-9.



>Revistas >Gaceta Médica de México >Año2013, No. 2
 

· Indice de Publicaciones 
· ligas de Interes 






       
Derechos Resevados 2019