medigraphic.com

2006, Número 1

<< Anterior Siguiente >>

Vet Mex 2006; 37 (1)


Protocolo diagnóstico y terapéutico en perros sospechosos de osteosarcoma (análisis retrospectivo de 28 casos clínicos)

Carmona LA, Santoscoy MC

Idioma: Español/Inglés
Referencias bibliográficas: 53
Paginas: 79-95
Archivo PDF: 507.35 Kb.


RESUMEN

Se analizaron 28 casos clínicos de perros sospechosos de osteosarcoma, que fueron atendidos en el Hospital Veterinario de la Facultad de Medicina veterinaria y Zootecnia de la Universidad Nacional Autónoma de México, durante enero de 2001 a agosto de 2003, con el propósito de identificar el estadio de enfermedad, así como las características clínicas más frecuentes de los pacientes y determinar el número de casos con diagnóstico definitivo y tratamiento específico. Trece (57%) de los 28 casos se encontraron en estadio avanzado y 17 (60.7%) tuvieron una presentación clínica típica de osteosarcoma. En nueve de ellos (32.1%) se confirmó el diagnóstico y se dio tratamiento específico, mientras que en cuatro (14.2%) se diagnosticaron otras patologías, como carcinoma prostático, osteomielitis, hemangiopericitoma y carcinoma de células escamosas. Con base en las observaciones realizadas, se propone un protocolo diagnóstico y terapéutico individualizado en el que se utilicen recursos disponibles en México para pacientes con presentación clínica atípica y típica de osteosarcoma en estadio inicial y avanzado. Se sugiere poner especial énfasis en el diagnóstico temprano, así como en el cuidado integral del paciente con neoplasia ósea.


REFERENCIAS (EN ESTE ARTÍCULO)

  1. J Watson CL, Lucroy MD. Primary appendicular bone tumors in dogs. Compend Contin Educ Small Anim Pract 2002; 1:128-135.

  2. Berg J. Canine osteosarcoma. Amputation and chemotherapy. Vet Clin North Am Small Anim Pract 1996; 26: 111-121.

  3. Dernell WS, Rodney C, Straw RC, Withrow J. Tumors of the skeletal system. In: Withrow SJ, MacEwen GE, editors. Small animal clinical oncology. Philadelphia: W.B. Saunders company, 2001:378-417.

  4. Thompson KG, Pool RR. Malignant tumors of bones. In: Meuten DJ, editor. Tumors in domestic animals. Iowa: Iowa State Press, 2002:263-283.

  5. O`Brien MG, Withrow, Straw RC. Recent advances in the treatment of canine apendicular osteosarcoma. Compend Contin Educ Small Anim Pract 1993; 15: 939-947.

  6. Chun R, de Lorimier L. Update on the biology and management of canine osteosarcoma. Vet Clin North Am Small Anim Pract 2003; 33:491-516.

  7. Palmer N. Neoplastic and tumurous conditions of bones. In: Jubb KVF, Kennedy PC, Palmer N, editors Pathology of domestic animals. San Diego: Academic Press. 1993: 99-108.

  8. Waters DJ, Cooley DM. Skeletal neoplasms. In: Morrison WB, editor. Cancer in dogs and cats: Medical and surgical management. Baltimore: Williams and Wilkins, 1998: 639-654.

  9. Withrow SJ, Powers BE, Straw RC. Comparative aspects of osteosarcoma. Clin Orthop 1991; 270: 159-168.

  10. Withrow SJ. Why Worry about cancer in pets? In: Withrow Sj, MacEwen GE, editors. Small animal clinical oncology. Philadelphia: W.B. Saunders company, 2001: 1-3.

  11. Carberry CA, Harvey HJ. Owner satisfaction with limb amputation in dogs and cats. J Am Anim Hosp Assoc 1987; 23: 227-232.

  12. Ramírez G, Villalba C, Di Paolo J. Osteosarcoma. Memorias del quinto curso internacional de ortopedia; 2002 Marzo 19-21; Mèxico (DF). Mèxico (DF): Asociación Mexicana de Médicos Veterinarios Especialistas en Pequeñas Especies, AC, 2002: 26-34.

  13. Straw RC, Withrow SJ. Limb-Sparing surgery versus amputation for dogs with bone tumors. Vet Clin North Am Small Anim Pract 1996; 26:135-143.

  14. Laungenbach A, Anderson MA, Dambach DM, Sorenmo KU, Shofer FD. Extra-esqueletal osteosarcomas in dogs: a retrospective study of 169 cases (1986-1996). J Am Anim Hosp Assoc 1998; 34: 113-120.

  15. Smeele LE, Kostense PJ, Van der Waal. Effect of chemotherapy on survival of craniofacial osteosarcoma: a sistematic review of 201 patients. J Clin Oncology 1997; 15: 363-36.

  16. Blackburn G. Cancer avanzado: Un nuevo reto en la medicina nutricional. In: Procedings of the adjuvant nutrition in cancer treatment symposium; 1992 november 13-14; Tulusa OK. Tulusa, OK: American College of Nutrition and the Cancer Treatment Centers of America, 1992 134-154.

  17. Ogilvie GK. Alterations in metabolism and nutritional support for veterinary cancer patients: Recent advances. Compend Contin Educ Small Anim Pract 1993; 15: 925-934.

  18. Tachibana K, Mukai K, Hirakua I. Evaluation of the effect of arginine enriched amino acid solution on tumor growth. J Parenter Enteral Nut 1985; 9:428-434.

  19. Ogilvie GK, Walters LM, Salman MD, Fettman MJ. Resting energy in dogs with nonhematopoietic malignancies before and after excision of tumors. Am J Vet Res 1996; 57: 1463-1467.

  20. Mazzaferro EM, Hackett TB, Stein TP, Ogilvie GK, Wingfield WE, Walton J, et al. Metabolic alterations in dogs with osteosarcoma. Am J Vet Res 2001; 62: 1234-1239.

  21. Sackman JE. Pain. Control of pain in animals. Compend Contin Educ Small Anim Pract 1991; 13:181-192.

  22. Wallace MS, Zawie DA, Garvey MS. Gastric ulceration in the dog secondary to the use of nonsteroidal anti-inflamatory drugs. J Am Anim Hosp Assoc 1990; 26:467-472.

  23. Forrester SD, Troy GC. Renal Effects of nonsteroidal antiinflammatory drugs. Compend Contin Educ Small Anim Pract 1999; 21: 910-916.

  24. Powers BE, LaRue SM, Withrow SJ, Sraw RC. Jamshidi needle biopsy for diagnosis of bone lesions in small animals. J Am Vet Med Assoc 1988; 193: 206-207.

  25. Bacci G, Ferrari S, Longhi A, Perin S, Fabbri N. Patrón de recidiva en pacientes con osteosarcoma de extremidades tratado con quimioterapia neoadyuvante. Eur J Cancer 2001; 1: 251-257.

  26. Berg J, Weinstein MJ, Springfield DS, Rand WM. Results of surgery and doxorubicin chemotherapy Am Vet Med Assoc 1995; 206: 1555-1560.

  27. Powers BE, Withrow SJ, Thrall DE. Percent tumor necrosis as a predictor of treatment response in canine osteosarcoma. Cancer 1991; 67: 126-134.

  28. Davis AM, Bell RS, Goodwin PJ: Prognostic factors in osteosarcoma: a critical review. J Clin Oncol 1994; 12: 423-431.

  29. Goorin AM, Shuster JJ, Baker A. Changing pattern of pulmonary metastases with adjuvant chemotherapy in patients with osteosarcoma: results from the multiinstitutional osteosarcoma study. J Clin Oncol 1991; 9: 600-605.

  30. Hong SH, Kadosawa T. Effect of all-trans and 9 cis retinoic acid on growth and metastasis of xenotransplanted canine osteosarcoma cells in athynic mice. Am J Vet Res 2000; 61: 1241-1244.

  31. Hong SH, Mochizuki M, Nishimura R, Sasaki N, Kadosawa T, Matsunaga S. Differentiation induction of canine osteosarcoma cell lines by retinoids. Res Vet Sci 2000; 68: 57-62.

  32. Hong SH, Ohasi E, Kadosawa T, Mochizuki M, Matsunaga S, Nishimura R. et al. Retiniod receptors and the induction of apoptosis in canine osteosarcoa cells. J Vet Med Sci 2000; 62: 469-472.

  33. Barroga EF, Kadosawa T, Okumura M, Fujinaga T. Effects of vitamin D and retinoids on the differentiation and growth in vitro of canine osteosarcoma and its clonal cell lines. Res Vet Sci 1999; 66: 231-236.

  34. MacEwen EG, Helfand SC. Recent advances in the biologic therapy of cancer. Compend Contin Educ Small Anim Pract 1993; 7: 909-916.

  35. MacEwen EG, Kurzman ID. Canine osteosarcoma. Amputation and chemoimmunotherapy. Vet Clin North AM Small Anim Pract 1996; 26: 123-133.

  36. Kurzman ID, McEwen EG, Rosenthal RC, Fox LE, Keller ET, Helfand SC, et al. Adjuvant therapy for osteosarcoma in dogs: results of randomized clinical trials using combined liposome-encapsulated muramyl tripeptide and cisplatin. Clin Cancer Res 1995; 1: 1595-1681.

  37. Withrow SJ, Straw RC, Douple EB. Biodegradable polymer with cisplatin for treatment of canine osteosarcoma. Procedings on Veterinary oncology; 1992 february 18-20 Huston (Texas). Texas: Veterinary Cancer Society 1992; 1: 68-69.

  38. Kirpensteijn J, Steinheimer D, Park RD, Powers BE, Straw RC, Endenburg N, et al. Comparison of cemented and non-cemented allografts in dogs with osteosarcoma. Vet Comp Ortho Traumatol 1998; 11: 178-184.

  39. Hulse DA, Johnson AL. Ostectomía del radio. In: Fossum TW editor. Cirugía de pequeños animals. Buenos Aires: Intermédica; 1999: 670-652.

  40. Seguin B, Walsh PJ, Mason DR, Wisner ER, Parmenter JL, Dernell WS. Use of an ipsilateral vascularized ulnar transposition autograft for limb-sparing surgery of the distal radius in dogs: and anatomic and clinical study. Vet Surg 2003; 32: 69-79.

  41. Violas P, Kholer R, Mascerd E, Bollini G, Kalifa C, Dobusset J. et al. Conservative surgical treatment of osteogenic sarcoma of the limb in children and adolescents. J Bone Joint surg Br 2002; 84b: 1-25

  42. O´Brien MG, Straw RC, Withrow SJ, Powers BE, Jemensson VJ, Laferty M, et al. Resection of pulmonary metastases in canine osteosarcoma: 36 cases (1983-1992). Vet Surg 1993; 22: 105-109.

  43. Cardona RO, Gomes AS, Beltrano N. The use of a homologus bony implant, associated with cisplatin, to treat canine osteosarcoma. A Hora Veterin 1999; 19: 60-64.

  44. Bergman PJ, Mac Ewen EG, Kurzman ID, Henry CJ, Hammer AS, Knapp DW, et al. Amputation and carboplatin for treatment of dogs with osteosarcoma:48 cases (1991 to 1993). J Vet Intern Med 1996; 10: 76-81.

  45. Heyman SN, Rosen S, Silva P. Protective action of Glycine in cisplani nephrotoxicity. Kidney Int 1991; 40:273-279.

  46. Garzoto CK, Berg J. Pronostic significance of serum alkaline phosphatase activity in canine appendicular osteosarcoma. J Vet Intern Med 2000; 14: 587-592.

  47. Straw RC, Powers BE, Klausner J, Henderson RA, Morrison WB, McCaw DL, et al. Canine mandibular osteosarcoma: 51 Cases (1980-1992). J Am Anim Hosp Assoc 1996; 32: 257-262.

  48. Wheeler SJ, Sharp NJH. Neoplasia. In: Wheeler SJ, Sharp NJH, editors. Small Animal Spinal Disorders. Diagnosis and Surgery. Barcelona Spain: Mosby Wolfe, 1994: 156-168.

  49. Dickerson ME, Page RL. Retrospective analysis of axial skeleton osteosarcoma in 22 large-breed dogs. J Vet Intern Med 2001; 2: 120-124.

  50. Cuneyt S, Levent E. Transoral resection and reconstruction for primary osteogenic sarcoma of the second cervical vertebra. Spine 2001; 26: 1936-1941.

  51. Schena CJ, Stickle RL, Dunstan RW, Trapp AL, Reimann KA. Extraskeletal osteosarcoma in two dogs. J Am Vet Med Assoc 1989; 194:1452-1456.

  52. Kuntz CA, Dernell WS, Powers BE, Withrow S. Extraskeletal osteosarcomas in dogs: 14 cases. J Am Anim Hosp Assoc 1998; 34: 26-30.

  53. Chun R, Kurzman ID, Couto CG, Klausner J, Henry C, Mc Ewen EG. Cisplatin and doxorubicin combination chemotherapy for the treatment of canine osteosarcoma: a pilot study. J Vet Intern Med 2000; 14: 495-498.




2020     |     www.medigraphic.com