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>Revistas >Gaceta Médica de México >Año 2015, No. 4


Castelán-Martínez OD, Vivanco-Muñoz N, Falcón-Ramírez E, Valdés-Flores M, Clark P
Papel del polimorfismo Apa1 del gen VDR en el riesgo de osteoporosis en mujeres mexicanas posmenopáusicas
Gac Med Mex 2015; 151 (4)

Idioma: Español
Referencias bibliográficas: 51
Paginas: 472-476
Archivo PDF: 228.68 Kb.


Texto completo




RESUMEN

Objetivo: Analizar la asociación entre el polimorfismo Apa1 del receptor de vitamina D (VDR) y la osteoporosis en mujeres posmenopáusicas mexicanas. Material y métodos: Se realizó un estudio transversal para determinar la asociación entre el polimorfismo Apa1 del VDR (rs7975232) y la osteoporosis y la osteoporosis más fractura en 534 mujeres mestizas posmenopáusicas de la Ciudad de México. La densidad mineral ósea (DMO) se evaluó mediante absorciometría dual de rayos X (DXA). La genotipificación se realizó mediante PCR en tiempo real con un ensayo de discriminación alélica. Resultados: Las frecuencias alélicas de Apa1 no fueron diferentes entre los grupos. No se encontró ninguna asociación entre los genotipos Apa1 y la osteoporosis (AA, odds ratio [OR]: 1.08; intervalo de confianza [IC] 95%: 0.62-1.87; AC, OR: 0.70; IC 95%: 0.45-1.07). Se obtuvieron resultados similares para la osteoporosis más fractura (AA: OR: 0.93; IC 95%: 0.50-1.71; AC: OR: 0.70; IC 95%: 0.45-1.07). Después de ajustar por edad el resultado se mantuvo.


Palabras clave: Polimorfismo Apa1 VDR , Fractura, Mestizo Mexicano, Osteoporosis, Gen VDR .


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>Revistas >Gaceta Médica de México >Año2015, No. 4
 

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