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2015, Number 4

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Gac Med Mex 2015; 151 (4)

Apa1 VDR polymorphism and osteoporosis risk in postmenopausal mexican women

Castelán-Martínez OD, Vivanco-Muñoz N, Falcón-Ramírez E, Valdés-Flores M, Clark P

Language: Spanish
References: 51
Page: 472-476
PDF size: 228.68 Kb.


ABSTRACT

Aim: To analyze the association between Apa1 VDR polymorphism and osteoporosis in Mexican mestizo postmenopausal women. Methods: A cross-sectional study was conducted in 534 postmenopausal mestizo women from Mexico City to determine the association of the Apa1 Vitamin D Receptor gene polymorphism (rs7975232) with osteoporosis and osteoporosis plus fracture. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry. Genotyping was performed using real-time PCR with an allelic discrimination assay. Results: The Apa1 allele frequencies were no different between groups. No association was found between Apa1 genotypes and osteoporosis (AA, OR: 1.08; 95% CI: 0.62-1.87; AC, OR: 0.70; 95% CI: 0.45-1.07). Similar results were obtained for osteoporosis plus fracture (AA, OR: 0.93; 95% CI: 0.50-1.71; AC, OR: 0.70; 95% CI 0.45-1.07). After adjusting for age, the result remained. Conclusion: These findings are in agreement with previous studies reporting no association of Apa1 VDR polymorphism with osteoporosis.


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