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2016, Número 3

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Residente 2016; 11 (3)


Aspectos moleculares y clínicos relacionados al factor de diferenciación de crecimiento 15 (GDF-15) circulante

Guadiana-Lozano R, Mendoza-Vázquez G, González-Sánchez AG, Zavala-Cerna G, Espinoza-Gómez F, Nava-Zavala AH

Idioma: Español
Referencias bibliográficas: 26
Paginas: 111-119
Archivo PDF: 302.70 Kb.


RESUMEN

El factor de diferenciación de crecimiento 15 (GDF-15) es un factor de crecimiento miembro de la superfamilia del factor de crecimiento transformante β (TGF-β); se expresa en diferentes tejidos, pero principalmente se encuentra en abundancia en la placenta. Entre sus funciones destaca la regulación de la inflamación y apoptosis en los tejidos lesionados y durante los procesos de enfermedad. Sin embargo, las distintas señales transmitidas por el GDF-15 pueden variar en condiciones fisiológicas y patológicas teniendo un comportamiento opuesto, similar al TGF-β. Se ha demostrado que desempeña múltiples funciones en diversas patologías, incluyendo inflamación, cáncer, enfermedades cardiovasculares y obesidad. Los niveles séricos de GDF-15 son un marcador de severidad y progresión en diversos padecimientos y podría estar implicado en el tratamiento de algunos de ellos.


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