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2018, Número 5

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Revista Habanera de Ciencias Médicas 2018; 17 (5)


Marcadores serológicos de hepatopatías virales y autoinmunes en pacientes celíacos atendidos en el Instituto de Gastroenterología

La Rosa HD, Del Valle RL, Crespo VM, Rodríguez PCV, Vega SA

Idioma: Español
Referencias bibliográficas: 30
Paginas: 669-680
Archivo PDF: 511.83 Kb.


RESUMEN

Introducción: El espectro del compromiso hepático en la enfermedad celíaca es muy amplio e incluye hepatopatías virales y autoinmunes.
Objetivo: Caracterizar el comportamiento de los marcadores serológicos de hepatopatías virales y autoinmunes en pacientes celíacos adultos atendidos en el Instituto de Gastroenterología.
Materiales y Métodos: Se realizó un estudio observacional descriptivo transversal en el período comprendido entre marzo de 2016 y marzo 2017 en 43 pacientes adultos celíacos atendidos en el Instituto de Gastroenterología de La Habana. A todos, previo consentimiento informado se les realizaron estudios bioquímicos y serológicos para identificar infección por virus de hepatitis B, C y respuesta inmune humoral frente a autoanticuerpos hepáticos y sistémicos. Para el análisis estadístico se emplearon distribuciones de frecuencia y para la comparación entre los grupos se utilizó la probabilidad exacta de Fisher. Se consideró significativo una p < 0,05.
Resultados: El 58,1% de los pacientes presentó hipofosfatasemia y 14% hipertransaminasemia, sin coincidencias entre los casos registrados. El 100% de los celíacos fue negativo para el virus de hepatitis C. La positividad de autoanticuerpos hepáticos se registró entre 2,3% y 14% de los pacientes evaluados. Existió asociación significativa entre hipertransaminasemia y la presencia de anticuerpos séricos contra la transglutaminasa tisular.
Conclusiones: La expresión de marcadores de autoinmunidad hepática en los pacientes celíacos evaluados es frecuente, no así la presencia de marcadores de hepatopatías virales.


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