2018, Number 5
Serologic markers of viral and autoimmune liver diseases in celiac patients treated at the Institute of Gastroenterology
PDF size: 511.83 Kb.
ABSTRACTIntroduction: The spectrum of hepatic involvement in celiac disease is very broad and includes viral and autoimmune hepatopathies.
Objective: To characterize the behavior of serologic markers of viral and autoimmune hepatopathies in adult celiac patients treated at the Institute of Gastroenterology.
Materials and Methods: A cross-sectional observational study was conducted in 43 adult celiac patients treated at the Institute of Gastroenterology of Havana from March 2016 to March 2017. Prior informed consent, biochemical and serologic studies were carried out in all cases, in order to identify hepatitis B and C virus infections and humoral immune response to liver and systemic autoantibodies. Frequency distributions were used for statistical analysis, and Fisher's exact test was used for the comparison between groups.
Results: 58.1% of the patients presented hypophosphatasemia and hypertransaminasemia in 14%, with no coincidence between the cases recorded. The 100% of the celiac patients were negative for hepatitis C virus. The positivity of liver autoantibodies was recorded between 2,3% and 14% of the patients evaluated. There was a significant association between hypertransaminasemia and the presence of serum antibodies against tissue transglutaminase.
Conclusions: The expression markers of liver autoimmunity in celiac patients was frequent, but not the presence of markers of viral hepatopathy.
Cilleruelo ML, Fernández-Fernández S, Jiménez-Jiménez J, Rayo AI, de Larramendi CH. Prevalence and Natural History of Celiac Disease in a Cohort of At-risk Children. J Pediatr Gastroenterol Nutr. [Internet].2016[cited 30/10/2017];62(5).Available from: https://journals.lww.com/jpgn/Fulltext/2016/05000/ Prevalence_and_Natural_History_of_Celiac_Disease. 13.aspx
Altobelli E, Paduano R, Petrocelli R, Di Orio F. Burden of celiac disease in Europe: a review of its childhood and adulthood prevalence and incidence as of September 2014. Ann Ig. [Internet]. 2014[cited 30/10/2017];26(6):485-498. Available from https://www.researchgate.net/publication/2697685 80_Burden_of_Celiac_Disease_in_Europe_a_review_ of_its_childhood_and_adulthood_prevalence_and_i ncidence_as_of_September_2014
Castillo NE, Vanga RR, Theethira TG, Rubio- Tapia A, Murray JA, Villafuerte J, et al. Prevalence of abnormal liver function tests in celiac disease and the effect of a gluten-free diet in the US population. Am J Gastroenterol. [Internet]. 2015 Aug [cited 30/10/2017];110(8): 1216-22. Available from: http://www.ncbi.nlm.nih.gov/pubmed/26150087
Rostami-Nejad M, Haldane T, Aldulaimi D, Alavian SM, Zali MR, Rostami K. The role of celiac disease in severity of liver disorders and effect of a gluten free diet on diseases improvement. Hepat Mon. [Internet]. 2013 Act[cited 30/10/2017];13(10): [aprox. 12 p.]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC384 2525/pdf/hepatmon-13-10-11893.pdf
Wakim-Fleming J, Pagadala MR, McCullough AJ, López R, Bennett AE, Barnes DS, et al. Prevalence of celiac disease in cirrhosis and outcome of cirrhosis on a gluten free diet: a prospective study. J Hepatol. [Internet]. 2014[cited 30/10/2017];61(3): 558-563. Available from: https://www.sciencedirect.com/science/article/abs/ pii/S0168827814003614
Bhakta D, Hair C, Green L, Duong N, Thrift AP, Kramer JR, et al. Prevalence of Celiac Disease Among Unsuspected Patients Presenting to Open Access Endoscopy. Clin Gastroenterol Hepatol. [Internet]. 2017 Jan [cited 30/10/2017];15(1):137-139. Available from https://www.sciencedirect.com/science/article/pii/S 1542356516305663?via%3Dihub
De Oliveira P, De Carvalho DR, Brandi IV, Pratesi R. Serological prevalence of celiac disease in Brazilian population of multiple sclerosis, neuromyelitis optica and myelitis. Mult Scler Relat Disord [Internet]. 2016 Sep [cited 6/01/ 2018];9:125- 8. Available from: https://www.ncbi.nlm.nih.gov/pubmed/27645359
Singh P, Arora A, Strand TA, Leffler DA, Catassi C, Green PH, et al. Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis. Clin Gastroenterol Hepatol. [Internet]. 2018 Jun [cited 30/09/2018];16(6):823-836. Available from: https://www.cghjournal.org/article/S1542- 3565(17)30783-8/fulltext
Alavi Moghaddam M, Rostami Nejad M, Shalmani HM, Rostami K, Nazemalhosseini Mojarad E, Aldulaimi D, et al. The effects of gluten-free diet on hypertransaminasemia in patients with celiac disease. Int J Prev Med [Internet]. 2013[cited 30/10/2017];4(6):700-4. Available from: https://www.ncbi.nlm.nih.gov/pubmed/23930188
Drastich P, Honsova E, Lodererova A, Jaresova M, Pekarikova A, Hoffmanova I, et al. Celiac disease markers in patients with liver diseases: a single center large scale screening study. World J Gastroenterol [Internet]. 2012[cited 30/10/2017];18(43):6255-62. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC350 1774/
Parra-Medina R, Molano-Gonzalez N, Rojas- Villarraga A, Agmon-Levin N, Arango MT, Shoenfeld Y, et al. Prevalence of celiac disease in latin america: a systematic review and meta-regression. PLoS One. [Internet]. 2015 May [cited 30/10/2017];10(5):e0124040. Available from: http://www.ncbi.nlm.nih.gov/pubmed/25942408
Marlen Ivon CF, Zaily DG, Conde-Eduardo Leda Patricia DS, Enrique GG, Enrique AS, Yadina MP. Current Condition of Chronic Hepatitis B Virus Infection in Cuban Adults. Curr Ther Res Clin Exp[Internet]. 2017 May [cited 30/10/2017];85:15-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC568 1292/