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2019, Número 3

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salud publica mex 2019; 61 (3)


Tuberculosis y cáncer de pulmón

Molina-Romero C, Arrieta O, Hernández-Pando R
Texto completo Cómo citar este artículo Artículos similares

Idioma: Ingles.
Referencias bibliográficas: 46
Paginas: 286-291
Archivo PDF: 295.64 Kb.


PALABRAS CLAVE

tuberculosis, cáncer de pulmón, inflamación, EGFR, epidemiología.

RESUMEN

Objetivo. Describir los estudios que documentan la relación entre el cáncer de pulmón (CP) y la tuberculosis pulmonar (Tb) y sus posibles mecanismos moleculares. Material y métodos. Se revisaron bases de datos de publicaciones, usando como palabras clave CP y Tb. Resultados. Se ha propuesto que la inflamación crónica en el pulmón provocada por la Tb podría producir actividad clastogénica. Otra posibilidad es la transferencia lateral de genes; Mycobacterium tuberculosis (MTb) es un organismo intracelular facultativo cuyo DNA podría integrarse al material genético del epitelio bronquial induciendo transformación neoplásica. Conclusión. Existen evidencias epidemiológicas, particularmente en países asiáticos, que documentan la relación entre CP y Tb. MTb podría desempeñar un papel activo en la transformación neoplásica cuyo mecanismo debe de ser elucidado.


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