García CLM, Hernández JJ, Fernández RB, Hernández CPA, Pérez CME, Gallegos VIB

Idioma: Español
Referencias bibliográficas: 28
Paginas: 48-56
Archivo PDF: 357.72 Kb.

RESUMEN

El cáncer de mama es la segunda causa de muerte de mujeres en el mundo, sin embargo, si es diagnosticado oportunamente puede ser curado. Recientemente se ha observado que cambios en la estructura de los oligosacáridos de membrana, se relacionan con los procesos de transformación y proliferación celular, los cuales pueden originar el cáncer de mama. La glicosilación incompleta de glicoproteínas, expone nuevos antígenos, particularmente el antígeno Thomsen-Friedenreich (TF), Para la síntesis de este antígeno las células emplean enzimas denominadas glicosiltransferasas, especialmente las GalNac transferasas que adicionan el monosacárido GalNac a un residuo de serina o treonina. En esta revisión nos enfocaremos en el papel de las GalNac transferasas, en el desarrollo del cáncer de mama.

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