Parra-Ortega I, López-Valladares KE, Angeles-Floriano T, Moreno-González AM, López-Martínez B

Idioma: Español
Referencias bibliográficas: 34
Paginas: 198-203
Archivo PDF: 252.01 Kb.

RESUMEN

Antecedentes: Se ha descrito que las características clínicas de la hemofilia A grave se ven modificadas favorablemente por el efecto de factores protrombóticos, específicamente las mutaciones Leiden del factor V y la G20210A de la protrombina.
Objetivo: Comunicar los resultados de una serie de pacientes con hemofilia A grave a los que se les investigó la existencia de las mutaciones Leiden del factor V y la G20210A de la protrombina.
Pacientes y Método: Estudio prospectivo que de enero de 2008 a diciembre de 2017 incluyó pacientes con diagnóstico de hemofilia A grave, en ellos se investigaron las mutaciones Leiden del factor V y la G20210A de la protrombina por medio de reacción en cadena de la polimerasa en tiempo real.
Resultados: Se incluyeron 43 pacientes en los que no se identificaron las mutaciones Leiden del factor V y la G20210A de la protrombina.
Conclusiones: La existencia de las mutaciones Leiden del factor V y G20210A de la protrombina es infrecuente en pacientes pediátricos mexicanos con hemofilia A grave.

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